IL1 Cancer Research Results

IL1, Interleukin-1: Click to Expand ⟱
Source:
Type:
Interleukin-1 (IL-1) has long been known to be a key mediator of immunity and inflammation. Its dysregulation has been implicated in recent years in tumorigenesis and tumor progression, and its upregulation is thought to be associated with many tumors.

Interleukin-1 (IL-1) is a pro-inflammatory cytokine that plays a crucial role in the immune response and inflammation. It exists in two main forms: IL-1α and IL-1β, both of which are produced by various cell types, including macrophages, monocytes, and dendritic cells. IL-1 is involved in a wide range of biological processes, including cell proliferation, differentiation, and apoptosis.

IL-1 is often overexpressed in various cancers, including breast cancer, colorectal cancer, lung cancer, and melanoma. Its expression can be influenced by the tumor microenvironment and the presence of inflammatory cells.
Elevated levels of IL-1 are frequently associated with tumor progression and metastasis.

IL-1 is considered a pro-tumorigenic cytokine in many contexts. It can promote tumor growth by enhancing cell proliferation, survival, and angiogenesis. IL-1β, in particular, has been shown to stimulate the proliferation of cancer cells and promote the formation of new blood vessels (angiogenesis).
Scientific Papers found: Click to Expand⟱
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
391- AgNPs,    Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells
- in-vitro, Nor, NA
*VEGF↓, *IL1↓, toxicity↝, other↝,
2629- Ba,    Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion
- in-vivo, Nor, NA
*RenoP↑, *Apoptosis↓, *TNF-α↓, *IL1↓, *Bcl-2↑, *BAX↓, *Akt↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, AD, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *Synergy↑,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *CompStab↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, Synergy↑,
3227- EGCG,    Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury
- in-vivo, Nor, NA
*Rho↓, *IL1↓, *IL6↓, *TNF-α↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
4780- Lyco,    Potential inhibitory effect of lycopene on prostate cancer
- Review, Pca, NA
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
4782- Lyco,    New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, TumCI↓, TumCA↓, ROS↓, MMP2↓, MMP7↓, MMP9↓, VEGF↓, E-cadherin↑, TIMP1↑, TIMP2↑, BioAv↝, *IL12↓, *TNF-α↓, *IL1↓, *IL1β↓, *IL6↓, COX2/PTGS2↓, iNOS↓, *radioP↑, NF-kB↓, survivin↓, Casp3↑, Bax:Bcl2↑,
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,
2246- MF,    The Use of Pulsed Electromagnetic Field to Modulate Inflammation and Improve Tissue Regeneration: A Review
- in-vitro, Nor, NA
*Inflam↓, *IL1↓, *IL6↓, IL17↓, *TNF-α↓,
204- MFrot,  MF,    Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization
- in-vivo, AD, NA
*NF-kB↓, *MAPK↓, *TLR4↓, *memory↑, *cognitive↑, *TGF-β1↑, *ARG1/2↑, *IL4↑, *IL10↑, *IL6↓, *IL1↓, *TNF-α↓, *iNOS↓, *ROS↓, *NO↓, *MyD88↓, *p‑IKKα↓, *p‑IκB↓, *p‑p65↓, *p‑JNK↓, *p‑p38↓, *ERK↓, *neuroP↑, *Aβ↓,
8470- Mg,  Z,    The Effects of Magnesium and Zinc Co-Supplementation on Biomarkers of Inflammation and Oxidative Stress, and Gene Expression Related to Inflammation in Polycystic Ovary Syndrome: a Randomized Controlled Clinical Trial
- Trial, Nor, NA
*Dose?, *CRP↓, *PCO↓, *TAC↑, *IL1↓, *TNF-α↓,
9157- MG, MIC-1,    Isothiocyanate-enriched moringa seed extract alleviates ulcerative colitis symptoms in mice
- in-vivo, Col, NA
*colonLen↑, *TNF-α↓, *NO↓, *MPO↓, *IL1↓, *IL6↓, *iNOS↓, *CLDN1↑, *ZO-1↑, *GSTP1/GSTπ↑, *NRF2↑, *eff↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *Synergy↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,

Showing Research Papers: 1 to 19 of 19

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↓, 2,   ROS↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 2,   iNOS↓, 1,   necrosis↑, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt2↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMTs↓, 1,   FOXO1↓, 1,   HATs↓, 1,   HDAC↓, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↑, 1,   cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1?, 1,   TumCG↓, 1,   TumCP↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   IL17↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   PGE2↓, 2,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 2,   Risk↓, 2,   toxicity↝, 1,  
Total Targets: 68

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 2,   GPx↓, 1,   GPx↑, 1,   GSH↑, 4,   GSTs↑, 2,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 3,   MPO↓, 1,   NOX4↓, 1,   Nrf1↑, 1,   NRF2↑, 5,   PCO↓, 1,   RNS↓, 1,   ROS↓, 9,   selenoP↑, 1,   SOD↑, 3,   TAC↑, 2,   Thiols↑, 1,   Trx↑, 1,   uricA↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 1,   CRM↑, 1,   cytoP450↓, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   iNOS↓, 5,   necrosis↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   ERK↓, 2,   p‑IKKα↓, 1,   p‑IκB↓, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   STAT↓, 1,   STAT3↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↑, 1,   HSPs↓, 1,  

Migration(tgid=13) ⓘ

ARG1/2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   Rho↓, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 4,   VCAM-1↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↑, 1,   GLUT4↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 19,   IL10↑, 2,   IL12↓, 3,   IL1β↓, 2,   IL2↓, 1,   IL2↑, 1,   IL4↑, 2,   IL5↑, 1,   IL6↓, 15,   IL8↓, 5,   Imm↑, 1,   Inflam↓, 10,   MCP1/CCL2↓, 2,   MyD88↓, 1,   NF-kB↓, 9,   NLRP3↓, 2,   p‑p65↓, 1,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 18,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 1,   BDNF↑, 2,   MAOA↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   CompStab↑, 1,   Dose?, 1,   Dose↝, 4,   eff↑, 3,   GSTP1/GSTπ↑, 1,   Half-Life↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BP↓, 1,   colonLen↑, 1,   creat↓, 1,   CRP↓, 2,   IL6↓, 15,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 3,   cognitive↝, 1,   hepatoP↑, 1,   memory↑, 4,   neuroP↑, 6,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 119

Scientific Paper Hit Count for: IL1, Interleukin-1
4 Lycopene
3 Curcumin
2 Silver-NanoParticles
2 Magnetic Fields
1 Baicalein
1 Crocetin
1 EGCG (Epigallocatechin Gallate)
1 Magnetic Field Rotating
1 Magnesium
1 Zinc
1 Moringin
1 Methylsulfonylmethane
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:365  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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