Snail Cancer Research Results

Snail, SNAI1, Snail Family Transcriptional Repressor 1: Click to Expand ⟱

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Type:

<p><b>SNAI1 (<span class="wphighlight">Snail</span> Family Transcriptional Repressor 1; SNAIL/SNAIL1)</b> — C2H2 zinc-finger transcriptional repressor and major regulator of epithelial-to-mesenchymal transition (EMT). SNAI1 represses epithelial genes such as E-cadherin/CDH1 and promotes loss of epithelial phenotype, migration, invasion, stem-like characteristics, and treatment resistance.</p>

<p><b>Typical modulation in cancer:</b> ↑ SNAI1 is generally tumor-promoting and is associated with EMT, invasion, metastasis, cancer stemness, and resistance to therapy. Inhibition or downregulation of SNAI1 is generally considered anticancer.</p>

<p><b>Typical modulation in Alzheimer’s disease:</b> No well-established disease-associated direction; SNAI1 is primarily relevant to development, EMT-like transcriptional programs, fibrosis, and cancer.</p>
<br>
<b><span class="wphighlight">Snail</span></b> gene may show a role in recurrence of breast cancer by downregulating E-cadherin and inducing an epithelial to mesenchymal transition. <span class="wphighlight">Snail</span> promotes metastasis of breast cancer cells and overexpression of <span class="wphighlight">Snail</span> is a biomarker of poor clinical outcome for patients with breast cancer.<br>
<span class="wphighlight">Snail</span>, a repressor of E-cadherin and an inducer of EMT.<br>
<span class="wphighlight">Snail</span> (SNAI1):<br>
A transcription factor that plays a key role in the regulation of the epithelial-to-mesenchymal transition (EMT).<br>
It suppresses the expression of epithelial markers (such as E-cadherin) and upregulates mesenchymal markers, facilitating changes in cell adhesion and motility.<br>
EMT Induction:<br>
<span class="wphighlight">Snail</span> actively represses genes such as E-cadherin, a protein critical for cell–cell adhesion. Its upregulation leads to a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype, enhancing migratory potential.<br>
Invasion and Metastasis:<br>
Through EMT induction, <span class="wphighlight">Snail</span> facilitates tumor cell dissemination and invasion into surrounding tissues, thereby playing a central role in metastasis.<br>
<br>
Elevated levels of <span class="wphighlight">Snail</span> have been observed in a variety of cancers, including breast, colorectal, pancreatic, and head and neck cancers.<br>
Elevated <span class="wphighlight">Snail</span> expression is frequently associated with a worse prognosis, including lower overall survival rates and increased likelihood of metastasis.<br>

Scientific Papers found: Click to Expand⟱

1098-

BA,

Baicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2

in-vitro,

Nor,

MCF10

in-vivo,

NA,

mouse

*TumCMig↓, *F-actin↓, *E-cadherin↑, *ZO-1↑, *N-cadherin↓, *Vim↓, *Snail↓, *cal2↓, *Ca+2↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Migration(tgid=13) ⓘ

Ca+2↝, 1, cal2↓, 1, E-cadherin↑, 1, F-actin↓, 1, N-cadherin↓, 1, Snail↓, 1, TumCMig↓, 1, Vim↓, 1,

Barriers & Transport(tgid=15) ⓘ

ZO-1↑, 1,
Total Targets: 9

Scientific Paper Hit Count for: Snail, SNAI1, Snail Family Transcriptional Repressor 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:376  State#:%  Dir#:1
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Snail Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Migration(tgid=13) ⓘ

Barriers & Transport(tgid=15) ⓘ

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