Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
Scientific Papers found: Click to Expand⟱
7035- GA,    Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway
- in-vitro, IBD, Caco-2
*Inflam↓, *antiOx↑, *CLDN1↓, *OCLN↓, *ZO-1↓, *IL6↓, *IL1β↓, *TNF-α↓, *BAX↓, *BAD↓, *Casp3↓, *Casp8↓, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *TJ↑, *Apoptosis↓, *NF-kB↓, *MAPK↓,
7798- ISQ,  MOR,    Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin
- in-vitro, AD, NA
*ROS↓, *Casp3↓, *Casp8↓, *Casp9↓, *Aβ↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
9066- L-THE,    Chemoprotective effect of theanine in 1,2-dimethylhydrazine-induced colorectal cancer in rats via suppression of inflammatory parameters
- in-vivo, CRC, NA
*antiOx↑, *Inflam↓, Dose↝, Weight↑, TumVol↓, PGE2↓, COX2/PTGS2↓, MPO↓, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↑, *LDH↓, *CEA↓, *MAPK↓, *Casp3↓, *Casp9↓, *Casp8↓, chemoP↑,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

MPO↓, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↓, 1,   P70S6K↓, 1,   PI3K↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Migration(tgid=13) ⓘ

Cofilin↓, 1,   LIMK2↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   TumVol↓, 1,   Weight↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 2,   GSR↑, 1,   HO-1↑, 1,   hyperG↝, 1,   MDA↓, 2,   NRF2↑, 1,   RNS↓, 1,   ROS↓, 4,   SOD↑, 4,   SOD1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   lipidLev↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAD↓, 1,   BAX↓, 3,   Bcl-2↑, 1,   Casp3↓, 5,   cl‑Casp3↓, 1,   Casp8↓, 5,   cl‑Casp8↓, 1,   Casp9↓, 3,   Cyt‑c↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↓, 3,   MAPK↑, 1,   RIP1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   CLDN1↓, 1,   IBI↑, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↑, 1,   IL13↑, 1,   IL1β↓, 3,   IL6↓, 3,   Inflam↓, 3,   NF-kB↓, 2,   NF-kB↑, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioEnh↑, 1,   CYP2E1↓, 1,   Dose↝, 2,   eff↑, 1,   P-gp/ABCB1↓, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   CEA↓, 1,   IL6↓, 3,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   antiCG↑, 1,   AntiDiabetic↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Stroke↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 85

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
1 Gallic acid
1 isoquercitrin
1 Morin
1 Kaempferol
1 L-Theanine
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:44  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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