mTORC1 Cancer Research Results

mTORC1, mammalian target of rapamycin complex 1: Click to Expand ⟱
Source:
Type:
Crucial signaling node that integrates environmental cues to regulate cell survival, proliferation, and metabolism, and is often deregulated in human cancer.
Activation of mTOR signaling is associated with oncogenic cellular processes, making mTOR a promising target for treating multiple hallmarks of the cancer phenotype.
Scientific Papers found: Click to Expand⟱
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
6907- FIS,    Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
- in-vitro, AD, NA
*p‑tau↓, *NRF2↑, *mTORC1↓, *neuroP↑, *memory↑, *Inflam↓, *memory↑, *TFEB↑, *mTOR↓,
5794- Sper,    Spermidine induces autophagy by inhibiting the acetyltransferase EP300
- in-vitro, Nor, U2OS
*EP300↓, *mTORC1↓, *CRM↑, *HATs↓, *p62↓, *AntiAge↑, AntiCan↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↓, 1,   AMPK↑, 1,   CRM↓, 1,   CRM↑, 1,   SIRT1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↓, 1,   TFEB↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EP300↓, 1,   mTORC1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   memory↑, 2,   neuroP↑, 1,  
Total Targets: 18

Scientific Paper Hit Count for: mTORC1, mammalian target of rapamycin complex 1
1 Calorie Restriction Mimetics
1 HydroxyCitric Acid
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Garcinol
1 Fisetin
1 Spermidine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:440  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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