angioG Cancer Research Results

angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
-Tumour development and progression beyond a size of few millimetres‐cubed crucially depends on the onset of angiogenesis, that is, the ‘angiogenic switch’
Scientific Papers found: Click to Expand⟱
7979- AAS/EEAA,    Anti-angiogenic potential of an ethanol extract of Annona atemoya seeds in vitro and in vivo
- vitro+vivo, Nor, HUVECs - in-vitro, Lung, H460
*angioG↓, VEGF↓, Hif1a↓,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
1178- Ash,    Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription factor
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
*VEGF↓, *angioG↓, *ascitic↓, *Sp1/3/4↓,
5872- CA,    Nrf2/ARE-Mediated Antioxidant Actions of Pro-Electrophilic Drugs
- Review, Nor, NA
*NRF2↑, *GSH↑, *neuroP↑, *Inflam↓, *cardioP↑, *Obesity↓, *angioG↓, chemoP↑, *NF-kB↓,
6283- DL,    D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
- in-vivo, Nor, NA
*TGF-β1↓, *VEGF↓, *MDA↓, *GPx↑, *Catalase↑, *Inflam↓, *ROS↓, *angioG↓,
7192- EGb 761,    Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases
- in-vitro, Nor, HMEC
Risk↓, *TumCP↓, *TumCMig↓, *angioG↓,
1005- GI,    Ginger Constituent 6-Shogaol Inhibits Inflammation- and Angiogenesis-Related Cell Functions in Primary Human Endothelial Cells
- vitro+vivo, Nor, HUVECs
*NF-kB↓, *p65↓, *TLR4∅, *angioG↓, *TumCP↓, *VEGF↓, *Inflam↓, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *p‑JNK↓, *HO-1↑,
8253- LCA,    Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma
- in-vitro, SCC, HSC4
*AntiTum↑, *angioG↓, *AntiP↑, *antiOx↑, *Bacteria↓, *Inflam↓, tumCV↓, Sp1/3/4↓, p27/CDKN1B↑, P21↑, cycD1/CCND1↓, Mcl-1↓, survivin↓, Apoptosis↑,
3267- Lyco,    Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways
- in-vitro, Nor, HUVECs
*VEGF↓, *MMP2↓, *uPA↓, *Rac1↑, *TIMP2↑, *p38↓, *Akt↓, *angioG↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, Synergy↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
2999- PL,    Piperlongumine alleviates corneal allograft rejection via suppressing angiogenesis and inflammation
- in-vivo, Nor, HUVECs
*Inflam↓, *angioG↓, *Hif1a↓, *VEGF↓, *ICAM-1↓, *VCAM-1↓, *neuroP↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
3007- RosA,    Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
- Review, Nor, NA
*ROS↓, *lipid-P↓, *Inflam↓, *neuroP↑, *angioG↓, *Synergy↑, *AST↓, *ALAT↓, *GSSG↓, *eNOS↓, *iNOS↓, *NO↓, *NF-kB↓, *MMP2↓, *MDA↓, *TNF-α↓, *GSH↑, *SOD↑, *IL6↓, *PGE2↓, *COX2/PTGS2↓, *mTOR↑,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 4,   BAX↓, 1,   Bax:Bcl2↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   Mcl-1↓, 1,   MDM2↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CREB2↓, 1,   ERK↓, 1,   mTOR↓, 1,   PKCδ↓, 1,   RAS↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HATs↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   PCNA↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   Ki-67↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   Ki-67↓, 1,   TumCG↓, 2,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   KRAS↓, 1,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↑, 1,   P-gp/ABCB1↓, 1,   selectivity↑, 1,   Synergy↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

KRAS↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoP↑, 1,   Risk↓, 1,  
Total Targets: 62

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 3,   GSSG↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   MDA↓, 2,   Nrf1↑, 1,   NRF2↑, 2,   ROS↓, 4,   SOD↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   mTOR↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 2,  

Migration(tgid=13) ⓘ

MMP2↓, 2,   Rac1↑, 1,   TGF-β1↓, 1,   TIMP2↑, 1,   TumCMig↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   E-sel↓, 1,   eNOS↓, 1,   Hif1a↓, 1,   NO↓, 1,   VCAM-1↓, 2,   VEGF↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   ICAM-1↓, 2,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 8,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   p65↓, 1,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TLR4∅, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   Half-Life↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ascitic↓, 1,   AST↓, 1,   BP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   cardioP↑, 3,   hepatoP↑, 1,   neuroP↑, 5,   Obesity↓, 1,   Pain↓, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiP↑, 1,   Bacteria↓, 2,  
Total Targets: 74

Scientific Paper Hit Count for: angioG, angiogenesis
2 Rosmarinic acid
1 Annona atemoya Seed Extract
1 Andrographis
1 Ashwagandha(Withaferin A)
1 Carnosic acid
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Ginger/6-Shogaol/Gingerol
1 Licochalcone A
1 Lycopene
1 Magnolol
1 Piperlongumine
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:447  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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