lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
Source:
Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
2656- AL,    Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
- in-vitro, Park, PC12
*antiOx↑, *Apoptosis↓, *LDH↓, ROS↓, *lipid-P↓, *mtDam↓, *MMP↓, *Cyt‑c↓, *ATP∅, *Ca+2↝, *neuroP↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3546- ALA,    Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study
- Study, AD, NA
*antiOx↑, *ROS↓, *cognitive∅, *lipid-P↓, *memory↑, *ChAT↑, *Acetyl-CoA↑, *Aβ↓, *BioAv↑, *BBB↑, *toxicity∅,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3543- ALA,    The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
- Study, AD, NA
*cognitive↑, *antiOx↑, *Inflam↓, *neuroP↑, *Ach↑, *ROS↓, *GlucoseCon↑, *lipid-P↓, *GSH↑, *Acetyl-CoA↑,
3540- ALA,    Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?
- in-vitro, Nor, NA
*lipid-P↓, *H2O2↓, *IronCh↑,
4282- ALA,    Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial
- Trial, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *adiP↑, *cognitive∅, *BDNF↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
3676- Ash,    Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats
- in-vivo, Arthritis, NA
*CRP↓, *ROS↓, *lipid-P↓, *GSTs↓, *GSH↑, *antiOx↑, *Inflam↓,
3669- Ash,    Withanamides in Withania somnifera fruit protect PC-12 cells from beta-amyloid responsible for Alzheimer's diseas
- in-vitro, AD, PC12
*lipid-P↓, *antiOx↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5419- ASTX,    Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↓, AntiCan↑, *lipid-P↓, TumCP↓, Apoptosis↑, TumCCA↑, *SOD↑, *PGE2↓, *NO↓, *IL8↓, *IFN-γ↓, *cardioP↑, *NF-kB↓, *TNF-α↓, *BioAv↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
2625- Ba,  LT,    Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocyte
- in-vivo, Stroke, NA
*lipid-P↓, *ACSL4∅, *NRF2∅, *GPx4∅, *Ferroptosis↓, *ROS↓, *MDA↓, *eff↑, *HO-1∅,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3679- BBR,    Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway
- in-vivo, AD, NA
*Beclin-1/ATG6↑, *LC3B↑, *p62↓, *ROS↓, *lipid-P↓, *MDA↓, *Ferroptosis↓, *TfR1/CD71↓, *FTH1↑, *memory↑, *JNK↓, *p38↓, *Aβ↓, *Inflam↓,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
5561- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *cognitive↑, *BBB↑, *lipid-P↓, *eff↑,
5563- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease
- Review, AD, NA
*BBB↑, *lipid-P↓, *eff↑, *cognitive↑,
5473- BM,    Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *toxicity∅, *AChE↓, *ROS↓, *antiOx↑, *lipid-P↓, *cognitive↑, *memory↑, *Dose↝, *BioAv↓, *TumCCA↑, *BBB↝,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
3698- BM,    Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
- in-vivo, AD, NA
*lipid-P↓, *ROS↓, *neuroP↑,
760- Bor,    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
- in-vivo, AD, NA
*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
5713- Brut,    Standardized bergamot polyphenolic fraction – a comprehensive dietary supplement with pleiotropic properties compared to other selected natural lipid-lowering substances available on the market
- Review, Nor, NA
*eff↑, *lipid-P↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6554- BSB,  doxoR,    α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats
- in-vivo, Nor, NA
*cardioP↑, *chemoP↑, *antiOx↑, *ROS↓, *toxicity↓, *DNAdam↓, *lipid-P↓, *ER Stress↓,
6560- BSB,  doxoR,    Α-Bisabolol, a Component of German Chamomile Tea Attenuates NLRP3 Inflammasome Mediated Pyroptosis, NF-ΚB/MAPK Signaling Activation and Apoptosis by Invoking NRF2 Mediated Antioxidant Defense Systems in Doxorubicin-Induced Liver Injury in Rats
- in-vivo, Nor, NA
*lipid-P↓, *antiOx↑, *Apoptosis↓, *Inflam↓,
7955- BuckWS,    Buckwheat (Fagopyrum esculentum M.) Sprout Treated with Methyl Jasmonate (MeJA) Improved Anti-Adipogenic Activity Associated with the Oxidative Stress System in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*eff↑, *ROS↓, *lipid-P↓,
7957- BuckWS,    Improving the antioxidant activity of buckwheat (Fagopyrum tataricm Gaertn) sprout with trace element water
- Study, Nor, NA
*Dose↑, *eff↑, *eff↝, *ROS↓, *IronCh↑, *SOD↑, *lipid-P↓,
7516- CA,    Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *memory↑, *Learn↑, *cognitive↑, *ROS↓, *lipid-P↓, *NRF2↑, *HO-1↑, *Aβ↓, *BACE/β-secretase↓,

Showing Research Papers: 1 to 50 of 259
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 259

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 4,   Catalase↑, 3,   GPx↓, 1,   GPx↑, 2,   GSH↓, 12,   GSH↑, 3,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   HO-1↓, 2,   HO-1↑, 4,   lipid-P↓, 2,   MDA↓, 4,   MDA↑, 5,   NQO1↓, 2,   NQO1↑, 1,   NRF2↓, 3,   NRF2↑, 5,   ROS↓, 7,   ROS↑, 42,   ROS⇅, 2,   SOD?, 1,   SOD↓, 4,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 1,   Thiols↓, 1,   Trx1↑, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 1,   compII↓, 1,   ETC↓, 1,   Insulin↓, 1,   MFN2↑, 1,   MKK7↓, 1,   mtDam↑, 4,   PDH↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 2,   AMPK↑, 5,   ATP↓, 2,   ATP↑, 1,   FASN↓, 1,   FDG↓, 1,   glucose↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 1,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HK2↓, 3,   lactateProd↓, 2,   lipoGen↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PDK1 / PDPK1↓, 1,   SIRT1↓, 1,   SIRT1↑, 4,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 2,   Apoptosis↑, 41,   ASC↓, 1,   BAD↓, 1,   Bak↓, 1,   BAX↑, 24,   Bax:Bcl2↑, 4,   Bcl-2↓, 25,   Bcl-2↑, 1,   BID↑, 1,   BIM↑, 2,   BNIP3↑, 2,   Casp↑, 4,   Casp1↓, 1,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 26,   cl‑Casp3↑, 3,   cl‑Casp3⇅, 1,   Casp7↑, 6,   cl‑Casp7↑, 1,   Casp8↑, 9,   Casp9↑, 15,   cl‑Casp9↑, 2,   proCasp9↓, 1,   CellShr↑, 1,   cFLIP↓, 2,   Cyt‑c↑, 15,   DR5↓, 1,   DR5↑, 5,   FADD↑, 3,   Fas↑, 6,   FasL↑, 2,   IAP1↓, 2,   iNOS↓, 4,   MDM2↓, 3,   p‑MDM2↓, 1,   MOMP↑, 2,   p38↑, 6,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 8,   TNFR 1↑, 1,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 26,   Akt↑, 1,   p‑Akt↓, 7,   AMPKα↑, 1,   cMET↓, 1,   EGFR↓, 6,   EGFR↑, 2,   p‑EGFR↓, 1,   ERK↓, 6,   ERK↑, 1,   p‑ERK↓, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   HRAS↓, 1,   IGF-1R↓, 1,   IKKα↓, 2,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 7,   MAPK↑, 4,   MAPK↝, 1,   MKK4↓, 1,   mTOR↓, 15,   mTOR↝, 1,   p‑mTOR↓, 1,   P70S6K↓, 2,   PI3K↓, 24,   PI3K↑, 1,   p‑PI3K↓, 1,   PKCδ↓, 1,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 2,   RIP1↓, 1,   Sp1/3/4↓, 5,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 10,   p‑STAT3↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 6,   cMyc↑, 1,   FOXO1↑, 2,   FOXO3↝, 1,   p‑FOXO3↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 1,   HDAC1↓, 2,   HDAC2↓, 2,   miR-34a↓, 2,   OCT4↓, 3,   other↓, 1,   other↑, 3,   other↝, 3,   PhotoS↑, 1,   SOX2↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 2,   p‑eIF2α↑, 2,   ER Stress↑, 5,   HSP70/HSPA5↓, 1,   HSP90↓, 2,   HSPs↓, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 4,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 7,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 11,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 27,   PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PCNA↓, 9,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 4,   CDK1↑, 1,   CDK2↓, 6,   CDK4↓, 8,   CDK4↑, 1,   CDK6↓, 2,   CHK1↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 8,   cycD1/CCND1↓, 11,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 5,   cycE/CCNE↑, 1,   E2Fs↓, 2,   Ki-67↓, 6,   P21↓, 1,   P21↑, 13,   p27/CDKN1B↑, 2,   p‑pRB↓, 2,   RB1↓, 1,   RB1↑, 1,   TumCCA↑, 47,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   ALDH↓, 1,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD34↓, 1,   cFos↓, 1,   cFos↑, 1,   CSCs↓, 3,   Diff↑, 1,   FGF↓, 1,   Gli1↓, 1,   Ki-67↓, 6,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH↑, 1,   NOTCH1↓, 6,   Shh↓, 1,   TumCG↓, 13,   TumCP↓, 25,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   AXL↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   i-Ca+2↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   COL1↓, 1,   E-cadherin↓, 4,   E-cadherin↑, 10,   EMT↓, 13,   EpCAM↓, 2,   F-actin↓, 1,   FAK↓, 2,   p‑FAK↓, 1,   fascin↓, 2,   Fibronectin↓, 1,   ITGB1↓, 1,   KRAS↓, 1,   MET↓, 2,   p‑MET↓, 2,   MMP13↓, 1,   MMP2↓, 14,   MMP3↓, 2,   MMP9↓, 14,   MMP9↑, 1,   MMPs↓, 13,   N-cadherin↓, 9,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 2,   Slug↓, 3,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↑, 5,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 17,   TumCMig↓, 17,   TumMeta↓, 19,   TumMeta↑, 1,   Twist↓, 3,   Tyro3↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim↓, 6,   Vim↑, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   HIF-1↓, 1,   HIF-1↑, 1,   Hif1a↓, 7,   LOX1↓, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↓, 21,   VEGFR1↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   MMP↓, 15,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 20,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 2,   DR4↑, 2,   Eos↑, 1,   FOXP3↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 2,   IL1β↓, 3,   IL1β↑, 1,   IL2↑, 1,   IL6↓, 8,   IL8↓, 3,   Imm↑, 7,   Imm↝, 1,   Inflam↓, 8,   pol-M1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 28,   NF-kB↑, 3,   NK cell↑, 3,   NLRP3↓, 2,   NLRP3↑, 1,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 4,   PSA↓, 3,   T-Cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α↑, 1,   TRADD↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   PSEN1/PS1↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   ER-α36↓, 1,   ER(estro)↓, 1,   ER(estro)↑, 1,   ERα/ESR1↓, 1,   FGF21↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 5,   BioAv↑, 6,   BioAv↝, 4,   ChemoSen↑, 34,   ChemoSen↝, 1,   CYP1A1↓, 3,   Dose↑, 2,   Dose↝, 13,   eff↓, 2,   eff↑, 15,   Half-Life↓, 1,   MDR1↓, 2,   P-gp/ABCB1↓, 2,   P-gp/ABCB1↑, 1,   RadioS↑, 9,   selectivity↑, 18,   Synergy?, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 2,   AR↓, 2,   AST↓, 1,   BP↓, 1,   BUN↓, 1,   CEA↓, 2,   CIT↓, 1,   creat↓, 2,   EGFR↓, 6,   EGFR↑, 2,   p‑EGFR↓, 1,   ERα/ESR1↓, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 8,   KRAS↓, 1,   NSE↓, 1,   PD-L1↓, 3,   PSA↓, 3,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 20,   antiNeop↑, 1,   AntiTum↑, 7,   cachexia↓, 1,   cardioP↑, 6,   chemoP↑, 16,   chemoPv↑, 4,   cognitive↑, 2,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 2,   OS?, 1,   OS↑, 3,   Pain↓, 1,   QoL↑, 2,   radioP↑, 4,   RenoP↑, 2,   Risk↓, 4,   toxicity↓, 3,   toxicity↝, 1,   TumVol?, 1,   TumVol↓, 3,   TumW↓, 2,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 5,  
Total Targets: 449

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 140,   ARE↑, 3,   Bil↓, 2,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 86,   Fenton↓, 4,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 58,   GPx1↑, 3,   GPx4↓, 1,   GPx4↑, 3,   GPx4∅, 1,   GSH↓, 1,   GSH↑, 93,   GSH/GSSG↑, 1,   GSR↓, 1,   GSR↑, 19,   GSSG↓, 3,   GSTs↓, 3,   GSTs↑, 23,   H2O2↓, 10,   HDL↓, 1,   HDL↑, 5,   HDL∅, 1,   HNE↓, 1,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 48,   HO-1∅, 1,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 3,   Keap1↑, 1,   lipid-P↓, 260,   mt-lipid-P↓, 1,   MDA↓, 56,   MPO↓, 7,   NOX↓, 1,   NOX4↓, 3,   NQO1↑, 11,   Nrf1↑, 2,   NRF2↓, 2,   NRF2↑, 74,   NRF2∅, 1,   ONOO↓, 1,   Prx↑, 1,   RNS↓, 2,   ROS?, 2,   ROS↓, 191,   ROS↑, 1,   mt-ROS↓, 2,   selenoP↑, 2,   SOD?, 1,   SOD↓, 1,   SOD↑, 121,   mt-SOD↑, 1,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 13,   TBARS↓, 5,   Thiols↑, 2,   TOS↓, 3,   Trx↑, 2,   uricA↓, 2,   VitC↑, 6,   VitE↓, 1,   VitE↑, 3,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 17,   Mets↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIV↑, 2,   DRP1/DNM1L↑, 1,   ETC↑, 1,   FIS1↓, 2,   MFN1↓, 1,   MFN2↓, 1,   mitResp↑, 3,   mtDam↓, 10,   OCR↑, 1,   OPA1↓, 1,   PGC-1α↓, 1,   PGC-1α↑, 3,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 7,   ACC↑, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   ACSL4∅, 1,   adiP↑, 2,   ALAT↓, 33,   AMP↓, 1,   AMPK↓, 1,   AMPK↑, 16,   p‑AMPK↑, 1,   ATP↓, 1,   ATP↑, 15,   ATP∅, 1,   mt-ATP↑, 1,   Buty↑, 1,   CPT1A↑, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 1,   G6PD↑, 1,   glucose↓, 2,   glucose↑, 1,   glucose↝, 2,   GlucoseCon↑, 5,   GSK‐3β↓, 14,   GSK‐3β↑, 1,   H2S↑, 2,   HK2↑, 1,   HMG-CoA↓, 1,   IDH1↑, 1,   LDL↓, 16,   NAD↓, 1,   NADH:NAD↑, 1,   NADPH↓, 5,   NADPH↑, 3,   PGC1A↑, 1,   PLA2↓, 1,   PONs↑, 1,   SCD1↓, 1,   SCFAs↑, 2,   SIRT1↑, 17,   SREBP1/SREBF1↓, 2,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 22,   ASC↓, 1,   BAX↓, 16,   BAX↑, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 3,   Bcl-2↑, 11,   Bcl-xL↑, 1,   Casp↓, 2,   cl‑Casp1↓, 1,   Casp3↓, 24,   Casp3↑, 1,   cl‑Casp3↓, 2,   proCasp3↓, 1,   Casp9↓, 11,   Cyt‑c↓, 6,   Cyt‑c∅, 1,   Fas↓, 2,   Ferroptosis↓, 8,   GSDMD↓, 1,   iNOS↓, 31,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p38↑, 1,   p‑p38↓, 1,   Pyro↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   Akt↑, 8,   p‑Akt↓, 1,   CREB↑, 3,   p‑CREB↑, 2,   ERK↓, 5,   ERK↑, 1,   p‑ERK↓, 1,   IKKα↓, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JAK2↓, 2,   JAK2↑, 1,   JNK↓, 5,   JNK↑, 1,   p‑JNK↓, 3,   MAPK↓, 9,   MAPK↑, 3,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 2,   mTOR↑, 3,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 8,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 1,   PP2A↑, 1,   STAT↓, 1,   STAT3↓, 5,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cJun↓, 2,   cMyc↓, 1,   FOXO↑, 2,   FOXO3↑, 1,   HDAC↓, 1,   OCT4↓, 1,   other?, 2,   other↓, 6,   other↑, 9,   other↝, 17,   other∅, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   ER Stress↓, 6,   GRP78/BiP↓, 3,   GRP78/BiP↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSPs↓, 1,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↓, 1,   MitoP↑, 4,   p62↓, 2,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 13,   DNArepair↑, 1,   P53↓, 1,   P53↑, 1,   PCNA↑, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   GADD34↓, 1,   P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↓, 1,   Diff↑, 1,   Diff↝, 1,   IGF-1↑, 2,   IGFBP1↑, 1,   neuroG↑, 3,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 10,   AP-1↓, 3,   ATPase↑, 1,   Ca+2↓, 9,   Ca+2↝, 1,   Cartilage↑, 3,   COL1↓, 2,   COL1↑, 1,   Fibrosis↓, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 2,   MUC1↑, 1,   N-cadherin↑, 1,   PDGF↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 3,   TGF-β↑, 1,   TGF-β1↓, 1,   TregCell↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   TXNIP↓, 1,   Tyro3↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   angioG↑, 4,   CD31/PECAM-1↑, 1,   E-sel↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   p‑eNOS↑, 1,   LOX1↓, 1,   NO↓, 19,   NO↑, 1,   VCAM-1↓, 5,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 3,   BBB↑, 26,   BBB↝, 3,   GastroP↑, 6,   GLUT3↑, 1,   GLUT4↑, 2,   IBI↑, 3,   MMP↓, 2,   MMP↑, 17,   MUC19↓, 1,   MUC2↓, 1,   MUC5AC↓, 1,   OATPs↓, 1,   OCLN↑, 1,   TJ↑, 1,   TRPA1↑, 1,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 4,   CD8+↑, 1,   COX2/PTGS2↓, 47,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 9,   IFN-γ↑, 2,   IL1↓, 3,   IL10↓, 5,   IL10↑, 7,   IL12↓, 1,   IL17↓, 5,   IL18↓, 1,   IL1β↓, 51,   IL2↓, 4,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 1,   IL5↓, 1,   IL6↓, 50,   IL6↑, 2,   IL8↓, 8,   IL8↑, 1,   Imm↓, 1,   Imm↑, 8,   INF-γ↓, 1,   Inflam?, 1,   Inflam↓, 136,   Inflam↑, 2,   IRF3↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 7,   MyD88↓, 2,   NeuroI↓, 5,   NF-kB↓, 73,   NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 15,   p65↓, 1,   PGE2↓, 18,   RAGE↓, 1,   RANTES↓, 1,   TLR1↓, 2,   TLR2↓, 3,   TLR4↓, 11,   TLR4↑, 1,   TNF-α↓, 73,   TNF-α↑, 1,   Treg lymp↝, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   5HT↑, 5,   Ach↑, 9,   AChE↓, 47,   AChE↑, 1,   ADAM10↑, 1,   BChE↓, 8,   BDNF↓, 2,   BDNF↑, 22,   ChAT↑, 9,   ChE↓, 1,   DA↑, 1,   GABA↑, 2,   GABA↝, 1,   GDNF↑, 1,   MAOA↓, 5,   MAOA↑, 1,   MAOA↝, 1,   MAOB↓, 3,   monoA↓, 1,   monoA↑, 1,   NGF↑, 3,   PSD95↑, 4,   RELN↑, 1,   SNAP25↑, 2,   TPH1↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   APP↓, 4,   Aβ↓, 53,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   PSEN1/PS1↓, 1,   tau↓, 11,   p‑tau↓, 13,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   CYP19↓, 1,   END↑, 1,   ER(estro)↓, 1,   GLP-1R↑, 1,   GR↓, 1,   GR↑, 4,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 7,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 23,   BioAv↑, 50,   BioAv⇅, 1,   BioAv↝, 9,   BioEnh↑, 1,   ChemoSen↑, 2,   CompStab↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 4,   Dose↝, 21,   eff↓, 1,   eff↑, 27,   eff↝, 2,   GSTA1↓, 1,   Half-Life↓, 4,   Half-Life↑, 2,   Half-Life↝, 11,   P-gp/ABCB1↓, 1,   P450↓, 2,   P450↑, 1,   Synergy↑, 18,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 33,   ALB↝, 1,   ALP↓, 12,   AST↓, 33,   BG↓, 2,   Bil↓, 2,   Bil↑, 2,   BloodF↑, 4,   BMD↑, 3,   BP↓, 10,   BP↝, 1,   BP∅, 1,   BUN↓, 4,   CEA↓, 1,   CK/CK-MB↓, 1,   creat↓, 9,   CRP↓, 8,   IL6↓, 50,   IL6↑, 2,   LDH↓, 13,   LDH↑, 1,   NOS2↓, 3,   RAGE↓, 1,   SpO2↑, 1,   TC↓, 1,   TG/TAG↓, 5,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 9,   antiAll↑, 8,   AntiArt↑, 4,   AntiCan↑, 12,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 17,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 3,   cardioP↑, 59,   CardioT↓, 1,   chemoP↑, 6,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 62,   cognitive∅, 2,   diuretic↑, 3,   hepatoP↑, 59,   Learn↑, 6,   memory?, 1,   memory↓, 1,   memory↑, 64,   memory∅, 1,   Mood↑, 1,   motorD↓, 1,   motorD↑, 8,   Mucositis↓, 2,   neuroP↑, 111,   NP/CIPN↓, 1,   Obesity↓, 6,   OS↑, 3,   Pain↓, 3,   QoL↑, 1,   radioP↑, 7,   RenoP↑, 26,   Risk↓, 3,   Sleep↑, 2,   Strength↑, 3,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 28,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 4,   Weight↓, 2,   Weight↑, 1,   Weight∅, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 7,   AntiP↑, 1,   AntiViral↑, 4,   Bacteria↓, 14,   Diar↓, 1,   GutMicro↑, 20,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 2,   Ingr↑, 2,   Ingr↝, 5,  
Total Targets: 535

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
13 Thymoquinone
12 Curcumin
12 Quercetin
9 Alpha-Lipoic-Acid
9 Luteolin
8 Resveratrol
8 Silymarin (Milk Thistle) silibinin
7 Eugenol
7 Urolithin
6 Berberine
6 Carvacrol
6 Crocetin
6 Rosmarinic acid
5 Lycopene
4 Centella asiatica / Gotu kola → asiaticoside
4 Chrysin
4 Cinnamon
4 Ferulic acid
4 Selenium NanoParticles
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Ashwagandha(Withaferin A)
3 Bacopa monnieri
3 Boron
3 α-Bisabolol / Chamomile oil
3 doxorubicin
3 Caffeic acid
3 Chemotherapy
3 Dandelion Root
3 Cisplatin
3 EGCG (Epigallocatechin Gallate)
3 Hydrogen Gas
3 Licochalcone A
3 Moringa oleifera
3 Pterostilbene
2 1,8-Cineole
2 Baicalein
2 Beta-Caryophyllene
2 beta-carotene(VitA)
2 Boswellia (frankincense)
2 buckwheat sprouts
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carnosine
2 chitosan
2 Citicoline, CDP-Choline
2 Coenzyme Q10
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Spirulina(Arthrospira/Limnospira)
2 Emodin
2 Fisetin
2 phytic acid, Inositol hexakisphosphate
2 Shilajit/Fulvic Acid
2 Inositol
2 isoquercitrin
2 Kaempferol
2 Licorice
2 Melatonin
2 Marjoram (Origanum majorana)
2 Piperine
2 Rutin
2 Radiotherapy/Radiation
2 Vitexin
1 Astaxanthin
1 Aloe anthraquinones
1 Biochanin A
1 Bruteridin(bergamot juice)
1 Capsaicin
1 Propolis -bee glue
1 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 Chlorophyllin
1 Vitamin C (Ascorbic Acid)
1 Chocolate
1 Cichoric acid / Chicoric acid
1 methotrexate
1 Carica papaya leaf extract
1 Chlorella (Chlorella vulgaris)
1 diet Fermented Foods
1 D-limonene
1 Flaxseed/Linseed
1 Fucoidan
1 Gallic acid
1 Ginkgo biloba
1 Ginkgetin
1 Hibiscus sabdariffa
1 Hyperoside
1 Isoliquiritigenin
1 Isorhamnetin
1 isoflavones
1 SDG/lignans
1 Linalool
1 Methylene blue
1 MBE, Maqui berry
1 Matrine
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 Lemon Balm/Melissa officinalis
1 Methylsulfonylmethane
1 Nimbolide
1 Patchouli Oil (Pogostemon cablin)
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Phosphatidylserine
1 Silver-NanoParticles
1 Shankhpushpi
1 Selenite (Sodium)
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:453  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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