TfR1/CD71 Cancer Research Results

TfR1/CD71, Transferrin receptor protein 1,: Click to Expand ⟱
Source:
Type: gene/protein
Also called CD71
A protein that in humans is encoded by the TFRC gene. A protein that mediates iron uptake from transferrin into cells.
Transferrin receptor, which can control iron metabolism, is frequently expressed in tumor cells.
As is well known, TfR1 binds to iron-loaded transferrin and plays a pivotal role in cellular uptake of iron as well as ferritin sequesters and stores the cellular iron.


Scientific Papers found: Click to Expand⟱
3679- BBR,    Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway
- in-vivo, AD, NA
*Beclin-1/ATG6↑, *LC3B↑, *p62↓, *ROS↓, *lipid-P↓, *MDA↓, *Ferroptosis↓, *TfR1/CD71↓, *FTH1↑, *memory↑, *JNK↓, *p38↓, *Aβ↓, *Inflam↓,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, AD, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE/β-secretase↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GPx4↑, 1,   Iron↓, 2,   lipid-P↓, 1,   MDA↓, 2,   NOX↓, 1,   ROS↓, 4,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

Bax:Bcl2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 2,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CREB↑, 1,   ERK↑, 1,   JNK↓, 1,   PKA↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   p62↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,   PSD95↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   Half-Life↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 3,   memory↑, 1,   neuroP↑, 4,  
Total Targets: 37

Scientific Paper Hit Count for: TfR1/CD71, Transferrin receptor protein 1,
3 Huperzine A/Huperzia serrata
1 Berberine
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:465  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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