DNMTs Cancer Research Results

DNMTs, DNA methyltransferase: Click to Expand ⟱
Source:
Type:
DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses.

High expression levels of DNMTs, particularly DNMT1 and DNMT3A, are often associated with poor prognosis in several cancers. This is due to their role in promoting tumor growth, metastasis, and resistance to therapies.
Scientific Papers found: Click to Expand⟱
2701- BBR,    Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *Ferroptosis↓, *RenoP↑, *DNMT1↓, *DNMTs↓, *KLF4↑,
3234- EGCG,  Rad,    EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice
- in-vivo, Nor, NA
*DNMTs↓, *radioP↑, *HDAC↑,
3660- SFN,    Sulforaphane - role in aging and neurodegeneration
- Review, AD, NA
*antiOx↑, *Inflam↓, *NRF2↑, *NF-kB↓, *HDAC↓, *DNMTs↓, *neuroP↑, *AntiAge↑, *DNMT1↓, *DNMT3A↓, *memory↑, *HO-1↑, *ROS↓, *NO↓, *GSH↑, *NF-kB↓, *TNF-α↓, *IL10↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GSH↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 3,   HDAC↓, 1,   HDAC↑, 1,   KLF4↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   memory↑, 1,   neuroP↑, 1,   radioP↑, 1,   RenoP↑, 1,  
Total Targets: 22

Scientific Paper Hit Count for: DNMTs, DNA methyltransferase
1 Berberine
1 EGCG (Epigallocatechin Gallate)
1 Radiotherapy/Radiation
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:469  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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