LC3s Cancer Research Results

LC3s, Autophagosome Proteins: Click to Expand ⟱
Source:
Type:
LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in autophagy remains obscure.
Protumorigenic: In many cases, especially in advanced cancers, increased autophagy (reflected by high LC3 levels) can support tumor growth by providing nutrients and promoting cell survival under stress conditions.
Antitumorigenic: Conversely, in early-stage tumors or in response to certain therapies, autophagy can act as a tumor suppressor by preventing the accumulation of damaged organelles and proteins.
Scientific Papers found: Click to Expand⟱
4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
- in-vivo, Nor, NA
*ROS↓, *NRF2↑, *GPx1↑, *NQO1↑, *mTOR↑, *Beclin-1/ATG6↓, *ATG5↓, *LC3s↓, *hepatoP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

mTOR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1/ATG6↓, 1,   LC3s↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: LC3s, Autophagosome Proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:492  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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