IL17 Cancer Research Results
IL17, Interleukin-17: Click to Expand ⟱
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| Type: |
Also known as IL-17A.
Interleukin-17A is a protein that in humans is encoded by the IL17A gene.
Higher levels of serum IL-17 are associated with poor prognosis for a variety of solid tumors in cancer patients.
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Scientific Papers found: Click to Expand⟱
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
*Inflam↓, *IL17↓, *TNF-α↓, *IL22↓, *STAT3↓, *other↝, *eff↑, *Dose?,
*ROS↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL17↓, *CXCR4↓, *COX2/PTGS2↓, *TLR4↓, *NO↓, *MDA↓, *XO↓, *antiAll↑,
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, Synergy↑, RadioS↑, HCAR2↑,
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Review, |
Arthritis, |
NA |
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- |
Review, |
IBD, |
NA |
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Review, |
AD, |
NA |
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- |
Review, |
Park, |
NA |
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*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
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Review, |
Park, |
NA |
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Review, |
Stroke, |
NA |
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*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
*Imm↑, *GastroP↑, *Inflam↓, AntiCan↑, *AntiBio↑, *hepatoP↑, *CD4+↑, *IFN-γ↓, *IL17↓, *GutMicro↑, *antiOx↑, *AST↓, *ALAT↓, *HDL↑, *LDL↓, *ROS↓, *lipid-P↓, *Inflam↓, *Aβ↓,
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, Synergy↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
*AntiCan↑, *Inflam↓, *antiOx↑, *AntiViral↑, *Bacteria↓, *antiAll↑, *Analgesic↑, *hepatoP↑, *cardioP↑, *neuroP↑, *toxicity↝, p38↓, IL6↓, JAK2↓, STAT3↓, Casp↑, PI3K↓, Akt↓, mTOR↓, Beclin-1/ATG6↑, PCNA↓, Bcl-2↓, XIAP↑, VEGF↓, NF-kB↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, survivin↓, OCT4↓, SOX2↓, p62↓, *TNF-α↓, *IL6↓, *HMGB1↓, *AntiArt↑, *NF-kB↓, *IL6↓, *IL8↓, *IL1β↓, *IL17↓, *TNF-α↓, *ROS↓, *NRF2?, *AST↓, *ALAT↓, *TGF-β↓, *α-SMA↓, *JAK2↑, *STAT3↑, *BioAv↝, *Half-Life↝, ChemoSen↑, ATP↓, ROS↑,
*BBB↑, *neuroP↑, *HMGB1↓, *NF-kB↓, *MyD88↓, *TLR4↓, *TRAF6↓, *Cyt‑c↓, *MDA↓, *Beclin-1/ATG6↑, *GPx↑, *IL23↓, *IL17↓, *NRF2↑, *HO-1↑, *SOD↑, *GSH↑, *Stroke↓, *BACE/β-secretase↓, *Aβ↓, *BDNF↑, *AChE↓, *BChE↓, *ROS↓, *memory↑, *NP/CIPN↓,
*CD4+↑, *MCP1/CCL2↓, RANTES↓, *MIP‑1α/CCL3↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
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Review, |
Var, |
NA |
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Review, |
AD, |
NA |
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*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
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Study, |
PSA, |
NA |
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in-vivo, |
NA, |
NA |
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ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
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Review, |
Var, |
NA |
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Review, |
AD, |
NA |
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Review, |
Arthritis, |
NA |
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*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
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in-vitro, |
PSA, |
HaCaT |
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in-vivo, |
NA, |
NA |
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*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
*IL4↓, *IL5↓, *IL13↓, *IL17↓, *IgE↓, *IFN-γ∅, *antiOx↑, *Inflam↓, *antiAll↑,
Showing Research Papers: 1 to 21 of 21
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↓, 1, ROS↑, 8,
Mitochondria & Bioenergetics(tgid=3) ⓘ
ETC↓, 1, mtDam↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ATP↓, 2, Glycolysis↓, 2, HK2↓, 1, PKM2↓, 1,
Cell Death(tgid=5) ⓘ
Apoptosis?, 1, Apoptosis↑, 5, BAX↓, 1, Bcl-2↓, 2, BNIP3↝, 1, Casp↑, 2, Cyt‑c↑, 2, Fas↑, 1, FasL↑, 1, MDM2↓, 1, p38↓, 1, survivin↓, 1, XIAP↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↓, 4, ERK↓, 2, HCAR2↑, 1, JAK2↓, 1, JNK↑, 1, mTOR↓, 3, PI3K↓, 3, PKCδ↓, 1, RAS↓, 1, Sp1/3/4↓, 1, STAT3↓, 4,
Transcription & Epigenetics(tgid=7) ⓘ
cMyc↓, 1, HDAC↓, 2, miR-34a↓, 1, OCT4↓, 1, SOX2↓, 1, tumCV↓, 2,
Protein Folding & ER Stress(tgid=8) ⓘ
ER Stress↑, 1, HSP70/HSPA5↓, 1, HSP90↓, 2,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1/ATG6↑, 1, p62↓, 1, TumAuto↑, 2,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↑, 2, cl‑PARP↑, 1, PCNA↓, 3, TOP2↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK1↓, 1, CDK2↓, 1, CDK4↓, 2, CDK6↓, 1, CycB/CCNB1↓, 1, cycD1/CCND1↓, 1, Ki-67↓, 2, P21↑, 1, TumCCA↑, 5,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
CSCs↓, 1, Ki-67↓, 2, NOTCH1↓, 1, TumCG↓, 2, TumCP↓, 1, Wnt↓, 1,
Migration(tgid=13) ⓘ
AP-1↓, 1, EMT↓, 2, KRAS↓, 1, MMP2↓, 2, MMP9↓, 1, Slug↓, 1, TRIB3↑, 1, TumCI↓, 1, TumCMig↓, 1, TumMeta↓, 2, TumMeta↑, 1, β-catenin/ZEB1↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 2, Hif1a↓, 1, VEGF↓, 2,
Barriers & Transport(tgid=15) ⓘ
GLUT1↓, 1, MMP↓, 2,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, HCAR2↑, 1, IL6↓, 1, Imm↑, 1, Inflam↓, 1, NF-kB↓, 2, NF-kB↑, 1, NLRP3↓, 1, RANTES↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, ChemoSen↑, 5, Dose↝, 1, eff↑, 3, P-gp/ABCB1↓, 3, RadioS↑, 2, selectivity↑, 2, Synergy↑, 6,
Clinical Biomarkers(tgid=22) ⓘ
IL6↓, 1, KRAS↓, 1, TG/TAG↓, 1, TRIB3↑, 1,
Functional Outcomes(tgid=23) ⓘ
AntiCan↑, 3, chemoP↑, 1, K17↓, 1,
Infection & Microbiome(tgid=24) ⓘ
GutMicro↑, 1,
Total Targets: 105
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 7, Catalase↑, 3, DPPH↓, 1, GPx↑, 5, GPx4↓, 1, GSH↑, 5, GSR↑, 1, HDL↓, 1, HDL↑, 1, HO-1↑, 6, HO-1↝, 1, Iron↓, 1, lipid-P↓, 5, lipid-P↑, 1, MDA↓, 5, MPO↓, 1, NQO1↑, 1, Nrf1↑, 1, NRF2?, 1, NRF2↓, 1, NRF2↑, 6, ROS?, 1, ROS↓, 12, ROS↝, 1, SOD↑, 6, SOD1↑, 1, TBARS↓, 1, VitC↑, 1,
Metal & Cofactor Biology(tgid=2) ⓘ
NCOA4↝, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
5LO↓, 1, ALAT↓, 3, AMPK↓, 1, AMPK↑, 1, ATP↓, 1, GSK‐3β↓, 4, LDL↓, 3, NAD↓, 1, NADPH↓, 1, SIRT1↑, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 3, BAX↓, 1, Bcl-2↓, 1, Casp3↓, 2, Casp9↓, 2, Cyt‑c↓, 3, Ferroptosis↓, 1, iNOS↓, 3,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↓, 2, p‑ERK↓, 1, IKKα↓, 2, JAK2↑, 1, JNK↓, 1, MAPK↓, 2, mTOR↓, 1, PI3K↓, 1, STAT3↓, 2, STAT3↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
ATF4↓, 1, HDAC↓, 1, other↓, 1, other↑, 2, other↝, 4,
Protein Folding & ER Stress(tgid=8) ⓘ
CHOP/DDIT3↓, 1, HSP70/HSPA5↓, 1, HSP70/HSPA5↑, 1, HSPs↑, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1/ATG6↓, 1, Beclin-1/ATG6↑, 1, LC3II↓, 1,
DNA Damage & Repair(tgid=10) ⓘ
DNAdam↓, 1, P53↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK5↓, 1, GADD34↓, 1, P21↓, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
tyrosinase↓, 1,
Migration(tgid=13) ⓘ
EMT↓, 1, MMP9↓, 2, MUC1↑, 1, Snail↑, 1, TGF-β↓, 1, Twist↑, 1, TXNIP↓, 1, Vim↑, 1, α-SMA↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1, E-sel↓, 1, NO↓, 4, VCAM-1↓, 1, VEGF↓, 1,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 1, CLDN1↑, 1, GastroP↑, 1, IBI↑, 1, MMP↑, 1, MUC2↑, 1, OCLN↑, 1, TJ↑, 1, ZO-1↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
CD25+↓, 1, CD4+↑, 2, CD69↓, 1, COX1↓, 1, COX2/PTGS2↓, 7, CTLA-4↓, 1, CXCc↓, 1, CXCR4↓, 2, HMGB1↓, 2, ICAM-1↓, 1, IFN-γ↓, 8, IFN-γ∅, 1, IgE↓, 1, IL10↓, 3, IL10↑, 4, IL12↓, 1, IL13↓, 1, IL17↓, 21, IL18↓, 1, IL1β↓, 11, IL2↓, 2, IL22↓, 2, IL23↓, 3, IL4↓, 2, IL5↓, 1, IL6↓, 12, IL8↓, 4, Imm↓, 1, Imm↑, 1, Inflam↓, 16, MCP1/CCL2↓, 4, MIP‑1α/CCL3↓, 1, MyD88↓, 1, NF-kB↓, 7, NLRP3↓, 1, PGE2↓, 4, TLR4↓, 3, TNF-α↓, 13, TNF-α↑, 1, TRAF6↓, 1, Treg lymp↓, 1,
Synaptic & Neurotransmission(tgid=18) ⓘ
AChE↓, 4, BChE↓, 1, BDNF↓, 1, BDNF↑, 2,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 5, BACE/β-secretase↓, 2, tau↓, 1, p‑tau↓, 1, XO↓, 1,
Hormonal & Nuclear Receptors(tgid=20) ⓘ
GR↑, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 2, BioAv↑, 1, BioAv↝, 1, Dose?, 1, Dose⇅, 1, eff↑, 3, eff↝, 1, Half-Life↑, 1, Half-Life↝, 1,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 3, AST↓, 3, BP↓, 1, CRP↓, 1, IL6↓, 12,
Functional Outcomes(tgid=23) ⓘ
Analgesic↑, 1, AntiAge↑, 1, antiAll↑, 3, AntiArt↑, 2, AntiCan↑, 1, AntiDiabetic↑, 2, cardioP↑, 2, hepatoP↑, 6, memory↑, 3, neuroP↑, 9, NP/CIPN↓, 1, OS↑, 1, Pain↓, 1, PDE4↓, 1, RenoP↑, 1, Stroke↓, 1, toxicity↓, 1, toxicity↝, 2,
Infection & Microbiome(tgid=24) ⓘ
AntiBio↑, 1, AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 2, GutMicro↑, 2,
Total Targets: 186
Scientific Paper Hit Count for: IL17, Interleukin-17
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:540 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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