| Source: |
| Type: |
| A cytokine that regulates humoral and adaptive immunity, and is involved in allergies and regulates inflammation. IL-4 produced by cancer cells promotes resistance to immune checkpoint blockade (ICB). The close correlation between interleukin-4 (IL-4) and tumor progression has been observed in plenty of studies. IL-4 is expressed in various cancers, including breast cancer, lung cancer, colorectal cancer, and hematological malignancies. Its expression can vary depending on the tumor type and the immune context. Elevated levels of IL-4 are often associated with the presence of tumor-infiltrating immune cells, particularly Th2 cells and other immune cells that produce IL-4. IL-4 is often considered a pro-tumorigenic cytokine. It can promote tumor growth and survival by enhancing the proliferation and survival of cancer cells. IL-4 can activate signaling pathways such as the STAT6 pathway, which is associated with cell proliferation and survival. In some cancers, IL-4 can also promote angiogenesis, the formation of new blood vessels, which is critical for tumor growth and metastasis. |
| 6462- | 1,8-Cin, | Modes of Action of 1,8-Cineol in Infections and Inflammation |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 3581- | CUR, | Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease |
| - | in-vivo, | AD, | NA |
| 2818- | CUR, | Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways |
| - | Review, | AD, | NA |
| 7482- | H2, | Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application |
| - | Review, | Var, | NA | - | Review, | IBD, | NA | - | Review, | Stroke, | NA | - | Review, | Sepsis, | NA | - | Review, | AD, | NA |
| 7927- | H2, | Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients |
| - | Human, | Asthma, | NA |
| 7929- | H2, | Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma |
| - | in-vivo, | Asthma, | NA |
| 7926- | H2, | Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model |
| - | in-vivo, | Asthma, | NA |
| 7925- | H2, | Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice |
| - | in-vivo, | Asthma, | NA |
| 7932- | H2, | Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model |
| - | in-vivo, | Asthma, | NA |
| 7933- | H2, | Hydrogen inhalation ameliorates lung inflammation in mice with asthma |
| - | in-vivo, | Asthma, | NA |
| 2521- | H2, | Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer |
| - | Review, | CRC, | NA | - | Review, | Lung, | NA | - | Review, | BC, | NA |
| 8377- | LT, | Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases |
| - | Review, | Asthma, | NA |
| 3597- | PI, | Chronic diseases, inflammation, and spices: how are they linked? |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Var, | NA |
| 1164- | PI, | Inhibition of T cell activation by the phytochemical piperine |
| - | in-vitro, | Nor, | NA |
| 3927- | PTS, | Effects of Pterostilbene on Cardiovascular Health and Disease |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA |
| 3314- | SIL, | Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review |
| - | Review, | Nor, | NA |
| 3300- | SIL, | Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy |
| - | Review, | Var, | NA |
| 3319- | SIL, | Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 3646- | SIL, | "Silymarin", a promising pharmacological agent for treatment of diseases |
| - | Review, | Var, | NA |
| 7938- | TQ, | The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma |
| - | in-vivo, | Asthma, | NA |
| 7939- | TQ, | Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis |
| - | Review, | Asthma, | NA |
| 7940- | TQ, | Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation |
| - | in-vivo, | Asthma, | NA |
| 7942- | TQ, | Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice |
| - | in-vitro, | Asthma, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:561 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid