COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
5313- acet,    Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?
- Review, Nor, NA
*COX2/PTGS2↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1077- Api,    Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice
- in-vivo, NMSC, NA
*COX2/PTGS2↓, COX2/PTGS2∅,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2/PTGS2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
3666- ART/DHA,    Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling
- in-vivo, AD, NA
*Inflam↓, *neuroP↑, *TLR4↓, *NF-kB↓, *memory↑, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *cognitive↑,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, Nor, NA
*COX1↓, *COX2/PTGS2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5411- ASA,    Mechanistic Insights into a Classic Wonder Drug—Aspirin
- Review, Var, NA
*COX2/PTGS2↓, *COX1↓, *Inflam↓, *cardioP↑, Risk↓,
5402- ASA,    Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
- Review, Var, NA
COX1↓, TumMeta↓, *Half-Life↓, *COX2/PTGS2↓, *TXA2↓,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2/PTGS2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
3518- Bor,    Boron Report
- Review, Var, NA - Review, AD, NA
Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2/PTGS2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,
3520- Bor,    Effect of boron element on photoaging in rats
- in-vivo, Nor, NA
*hepatoP↑, *BMD↑, *COX2/PTGS2↓, *IL8↓, *NF-kB↓, *IL6↓, *TNF-α↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
8973- BRice,    Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
- in-vitro, Nor, RAW264.7
*Ingr↝, *Inflam↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *NF-kB↓, *AP-1↓, *p‑ERK↓, *p‑p38↓, *p‑JNK↓, *MAPK↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
6557- BSB,    Alpha-bisabolol protects against neonatal asthma by suppressing airway inflammatory signaling
- in-vivo, Nor, NA
*ROS↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL17↓, *CXCR4↓, *COX2/PTGS2↓, *TLR4↓, *NO↓, *MDA↓, *XO↓, *antiAll↑,
7946- BuckWS,    Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7)
- Study, Nor, NA
*ROS↓, *IronCh↑, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2/PTGS2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
2347- CAP,    Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
- in-vivo, Nor, NA - in-vitro, Nor, RAW264.7
*PKM2↓, *LDHA↓, *Warburg↓, *COX2/PTGS2↓, *Sepsis↓, *Inflam↓, *ECAR↓, *OCR↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2/PTGS2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑, *CompStab↑,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
5926- CAR,    An Updated Review of Research into Carvacrol and Its Biological Activities
- Review, Nor, NA - Review, AD, NA - Review, Asthma, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *toxicity↓, *Pain↓, *TRPV3↑, *NRF2↑, *Ca+2↑, *ATP↑, *5LO↓, *COX2/PTGS2↓, PGE2↓, *hepatoP↑, *AntiAg↑, *Diar↓, *cardioP↑, *other↝, *chemoPv↑, *cognitive↑, *AChE↓, *GastroP↑, *Synergy↑, *BChE↓, *CRP↓, *antiAll↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,

Showing Research Papers: 1 to 50 of 217
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 217

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 1,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 5,   Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 3,   MDA↑, 3,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 7,   ROS↓, 7,   ROS↑, 34,   ROS⇅, 2,   ROS↝, 1,   i-ROS↑, 1,   mt-ROS↑, 2,   SOD↓, 1,   SOD2↓, 3,   Thiols↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   HSP60/HSPD1↓, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 1,   ALAT↓, 2,   AMPK↓, 2,   AMPK↑, 3,   ATP↓, 1,   glucose↓, 2,   GlucoseCon↓, 2,   GlutMet↓, 1,   Glycolysis↓, 5,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 3,   HK2↓, 3,   lactateProd↓, 4,   LDHA↓, 2,   LDL↓, 1,   MCT4↓, 1,   NADPH↓, 1,   PDK1 / PDPK1↓, 2,   PKM2↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   TCA↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 29,   ASC↑, 1,   BAD↓, 1,   Bak↓, 1,   Bak↑, 1,   BAX↓, 2,   BAX↑, 16,   Bax:Bcl2↑, 4,   Bcl-2↓, 18,   Bcl-2↑, 1,   Bcl-xL↓, 4,   BID↑, 1,   BIM↑, 1,   BNIP3↑, 2,   BNIP3↝, 1,   Casp↑, 2,   Casp↝, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 23,   cl‑Casp3↑, 2,   Casp7↑, 4,   cl‑Casp7↑, 1,   Casp8↑, 10,   Casp9↑, 12,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 12,   Diablo↑, 1,   DR5↑, 2,   Fap1↓, 1,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 1,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 4,   Mcl-1↓, 1,   MDM2↓, 3,   Necroptosis↑, 2,   necrosis↑, 1,   p38↑, 3,   Perforin↝, 1,   survivin↓, 7,   TRAIL↑, 1,   TumCD↑, 2,   XIAP↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 27,   Akt↑, 1,   p‑Akt↓, 6,   cMET↓, 1,   p‑cMET↑, 1,   EGFR↓, 4,   EGFR↑, 1,   ERK↓, 8,   p‑ERK↓, 1,   HER2/EBBR2↓, 4,   HGF/c-Met↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 1,   JNK↑, 5,   MAPK↓, 7,   MAPK↑, 1,   MARK4↓, 1,   MKK4↓, 1,   mTOR↓, 15,   PI3K↓, 26,   p‑PI3K↓, 2,   PKCδ↓, 4,   PTEN↑, 5,   RAS↓, 2,   RAS↑, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 12,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   cJun↓, 3,   cMyc↓, 9,   DNMT1↓, 2,   DNMTs↓, 1,   FOXM1↓, 3,   FOXO3↓, 1,   FOXO3↝, 1,   HDAC↓, 4,   HDAC1↓, 2,   HDAC2↓, 1,   HES1↓, 1,   Myc↓, 2,   MYCN↓, 1,   OCT4↓, 3,   other↓, 1,   other↑, 1,   SOX2↓, 1,   SOX9↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 3,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 4,   HSP90↑, 1,   HSPs↓, 1,   HTRA↓, 1,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSB↓, 1,   CTSD↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 3,   p62↓, 1,   p62↑, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,   DNAdam↑, 14,   hTERT/TERT↓, 1,   P53↓, 1,   P53↑, 14,   P53↝, 1,   p‑P53↑, 1,   p73↑, 1,   PARP↑, 6,   cl‑PARP↑, 8,   PCNA↓, 4,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   p‑CDK1↓, 1,   CDK2↓, 5,   CDK2↑, 1,   CDK4↓, 9,   CDK6↓, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 14,   cycE/CCNE↓, 3,   cycE/CCNE↑, 2,   E2Fs↓, 3,   Ki-67↓, 3,   P21↓, 1,   P21↑, 13,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   pRB↓, 1,   p‑RB1↓, 1,   TumCCA↑, 36,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 1,   CD133↑, 1,   cFos↓, 1,   CSCs↓, 5,   Diff↑, 1,   FGF↓, 1,   IGF-1?, 1,   IGF-1↓, 1,   IGF-2↓, 1,   Ki-67↓, 3,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH1↑, 1,   Shh↓, 1,   TumCG↓, 11,   TumCG↑, 2,   TumCP↓, 22,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   i-Ca+2?, 1,   i-Ca+2↑, 1,   cal2↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 6,   EMT↓, 10,   EMT↝, 1,   EpCAM↓, 2,   p‑FAK↓, 2,   Fibronectin↓, 1,   GIT1↓, 1,   KRAS↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 16,   MMP3↓, 1,   MMP7↓, 2,   MMP9↓, 21,   MMP9↑, 1,   MMPs↓, 10,   N-cadherin↓, 4,   PDGF↓, 1,   RECK↑, 1,   serineP↓, 1,   Slug?, 1,   Slug↓, 1,   Snail?, 1,   Snail↓, 1,   TET1↑, 2,   TGF-β↓, 1,   TIMP1↑, 3,   TIMP2↓, 1,   TIMP2↑, 3,   TumCI↓, 11,   TumCMig↓, 13,   TumMeta↓, 12,   TumMeta↑, 1,   Twist↓, 4,   uPA↓, 3,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 21,   angioG↑, 1,   CD31/PECAM-1↓, 1,   Hif1a↓, 13,   NO↑, 1,   VEGF↓, 30,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   GLUT1↓, 3,   MMP↓, 16,   MMP↑, 2,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 3,   COX1↓, 1,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 2,   COX2/PTGS2∅, 1,   CXCL16↓, 1,   CXCR4↓, 2,   Eos↑, 1,   FOXP3↑, 1,   ICAM-1↓, 2,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL12↑, 1,   IL1β↓, 4,   IL2↓, 1,   IL6↓, 3,   IL6↑, 1,   IL8↓, 2,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 3,   MCP1/CCL2↓, 1,   Neut↑, 1,   NF-kB↓, 23,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 3,   p65↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGD2↓, 1,   PGE2↓, 2,   PSA↓, 2,   TLR4↓, 4,   TNF-α↓, 6,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   AhR↓, 1,   AR↓, 2,   CYP19↓, 1,   ER(estro)↑, 1,   PPARα↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 2,   BioEnh?, 1,   BioEnh↑, 2,   ChemoSen↑, 23,   CYP1A1↓, 1,   Dose↑, 1,   Dose↝, 6,   eff↓, 1,   eff↑, 8,   Half-Life↝, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 4,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 11,   Synergy↑, 12,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 2,   ALP↓, 1,   AR↓, 2,   BP↓, 1,   CA19-9↓, 1,   CEA↓, 2,   CRP↓, 1,   EGFR↓, 4,   EGFR↑, 1,   FOXM1↓, 3,   HER2/EBBR2↓, 4,   hTERT/TERT↓, 1,   IL6↓, 3,   IL6↑, 1,   KRAS↓, 1,   LDH↓, 1,   LDH↝, 1,   Myc↓, 2,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↓, 1,   AntiCan↑, 12,   antiNeop↑, 1,   AntiTum↑, 3,   cardioP↑, 3,   chemoP↑, 10,   chemoPv↑, 7,   cognitive?, 1,   cognitive↑, 2,   hepatoP↑, 4,   neuroP↑, 1,   OS?, 1,   OS↑, 1,   radioP↑, 6,   RenoP↑, 4,   Risk↓, 5,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 2,  
Total Targets: 422

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 4,   antiOx↑, 78,   ARE↑, 3,   Bil↑, 2,   Catalase↓, 2,   Catalase↑, 56,   Fenton↓, 2,   GCLC↑, 3,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 40,   GPx1↑, 1,   GPx4↑, 2,   GSH↑, 52,   GSR↓, 1,   GSR↑, 7,   GSSG↓, 2,   GSTs↓, 3,   GSTs↑, 12,   H2O2↓, 5,   HDL↑, 3,   HO-1↓, 1,   HO-1↑, 51,   HO-1⇅, 1,   Keap1↓, 4,   Keap1↑, 1,   lipid-P?, 1,   lipid-P↓, 47,   MDA↓, 51,   MPO↓, 12,   NADH↓, 1,   NOX↓, 1,   NOX1↓, 1,   NOX2↓, 1,   NOX4↓, 3,   NQO1↑, 10,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 73,   ONOO↓, 1,   Prx↑, 1,   RNS↓, 5,   ROS?, 1,   ROS↓, 148,   ROS↑, 2,   SOD↓, 1,   SOD↑, 81,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 4,   Thiols↑, 2,   TOS↓, 1,   TrxR↑, 2,   uricA↓, 2,   VitC↑, 2,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↑, 6,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mitResp↑, 1,   mtDam↓, 3,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 2,   SIRT3↑, 1,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   15-LOX/ALOX15↓, 1,   5LO↓, 14,   5LO↝, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 14,   AMPK↑, 9,   p‑AMPK↑, 1,   ATP↑, 5,   cAMP↑, 3,   cPLA2↓, 1,   DGAT1↓, 1,   ECAR↓, 1,   FAO↑, 1,   FASN↓, 2,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 11,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 1,   HMG-CoA↓, 2,   LDHA↓, 1,   LDL↓, 7,   lipidLev↓, 2,   LTC4↓, 1,   NAD↑, 1,   NADPH↓, 3,   NADPH↑, 2,   PGM1?, 1,   PKM2↓, 3,   SIRT1↑, 12,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   APAF1↓, 1,   Apoptosis↓, 15,   ASC↓, 1,   BAX↓, 16,   Bcl-2↓, 2,   Bcl-2↑, 6,   Casp↓, 2,   Casp1↓, 2,   Casp3↓, 19,   Casp3∅, 1,   cl‑Casp3↓, 1,   Casp6↓, 1,   Casp8↓, 1,   Casp9↓, 11,   cl‑Casp9↓, 1,   Cyt‑c↓, 4,   Cyt‑c∅, 1,   Fas↓, 3,   Ferroptosis↓, 3,   iNOS↓, 89,   iNOS↑, 2,   necrosis↓, 2,   p38↓, 7,   p‑p38↓, 4,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 6,   p‑Akt↓, 1,   p‑Akt↑, 1,   AKT1↓, 1,   CREB↑, 1,   EGFR↓, 2,   ERK↓, 5,   ERK↑, 2,   p‑ERK↓, 3,   p‑ERK↑, 2,   HGF/c-Met↑, 1,   IGF-1R↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IκB?, 1,   IκB↓, 1,   IκB↑, 1,   JAK↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 5,   MAPK?, 1,   MAPK↓, 17,   MAPK↑, 2,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 2,   p‑MKK4↑, 1,   mTOR↓, 1,   mTOR↑, 1,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 6,   PI3K↑, 3,   PKA↑, 1,   PKCδ↓, 1,   PKCδ↑, 2,   PTEN↓, 1,   PTEN↑, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 2,   p‑cJun↓, 2,   cMyc↓, 1,   HDAC↓, 2,   MEF2D↑, 1,   miR-34a↓, 1,   other↓, 5,   other↑, 13,   other↝, 10,   RUNX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   ER Stress↓, 4,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 5,   HSPs↑, 1,   IRE1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   MitoP↓, 1,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATR↑, 1,   p‑BRCA1↑, 1,   DNAdam↓, 3,   P53↓, 3,   P53↑, 1,   cl‑PARP↓, 1,   PCNA↓, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 2,   cycD1/CCND1↓, 1,   E2Fs↑, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   cFos↓, 1,   Diff↑, 1,   EP2↓, 1,   Ki-67↓, 1,   neuroG↑, 4,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 13,   AP-1↓, 11,   BACH1↓, 1,   Ca+2↓, 8,   Ca+2↑, 1,   Cartilage↑, 3,   COL1↓, 1,   COL1↑, 1,   MMP-10↓, 1,   MMP1↓, 2,   MMP13↓, 6,   MMP2↓, 6,   MMP3↓, 5,   MMP3↑, 1,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 5,   MMPs↑, 1,   MUC1↑, 2,   p‑Rac1↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β1↑, 1,   TIMP1↓, 1,   TIMP1↑, 2,   TumCI↓, 1,   TXNIP↓, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   E-sel↓, 2,   eNOS↓, 1,   Hif1a↓, 4,   LOX1↓, 2,   NO↓, 45,   NO↑, 2,   TXA2↓, 3,   VCAM-1↓, 5,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 22,   BBB↝, 3,   BBB∅, 2,   CLDN1↑, 2,   CLDN3↑, 1,   GastroP↑, 6,   GLUT2↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,   MMP↓, 1,   MMP↑, 11,   MMP∅, 1,   MUC2↑, 1,   OCLN↑, 3,   TJ↑, 2,   TRPC1↓, 1,   TRPM7↓, 2,   TRPV3↑, 2,   ZO-1↑, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 2,   CB2 / CNR2↑, 3,   CD19↑, 1,   CD4+↑, 2,   CD8+↑, 1,   COX1↓, 15,   COX2/PTGS2↓, 219,   COX2/PTGS2∅, 1,   CXCc↓, 1,   CXCR4↓, 2,   Eos↓, 1,   HMGB1↓, 2,   ICAM-1↓, 6,   IFN-γ↓, 7,   IFN-γ↑, 3,   IL1↓, 4,   IL10↓, 6,   IL10↑, 13,   IL12↓, 5,   IL17↓, 7,   IL18↓, 2,   IL1β↓, 81,   IL2↓, 6,   IL2↑, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 85,   IL6↑, 2,   IL8↓, 17,   IL8↑, 1,   Imm↑, 9,   Imm⇅, 1,   INF-γ↓, 2,   Inflam?, 1,   Inflam↓, 140,   IRF3↓, 2,   LTA/TNF-β↓, 1,   MCP1/CCL2↓, 7,   MIP2↓, 1,   MyD88↓, 2,   NeuroI↓, 6,   Neut↑, 1,   NF-kB↓, 113,   NF-kB↑, 3,   p‑NF-kB↓, 1,   NK cell↑, 3,   NLRP3↓, 20,   p65↓, 2,   PGD2↓, 2,   PGE2↓, 53,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 1,   RANTES↓, 2,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 3,   TLR4↓, 20,   TLR4↑, 1,   TNF-α↓, 111,   TNF-α↑, 1,   TRIF↓, 1,   VitD↑, 1,   β-HEX↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 3,   Ach↑, 4,   AChE↓, 27,   AChE↑, 1,   AChE∅, 1,   BChE↓, 6,   BChE∅, 1,   BDNF↑, 18,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 3,   GABA↓, 1,   GABA↑, 1,   GDNF↑, 1,   MAOA↓, 1,   MAOA↑, 1,   NGF↑, 3,   PSD95↑, 3,   SNAP25↑, 2,   TrkB↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   APP↓, 1,   Aβ↓, 33,   Aβ42↓, 2,   BACE/β-secretase↓, 11,   tau↓, 7,   p‑tau↓, 4,   XO↓, 3,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

cortisol↓, 1,   DHT↓, 1,   GR↓, 1,   GR↑, 1,   PPARα↑, 5,   PPARα↝, 1,   PPARγ↑, 7,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 25,   BioAv↑, 43,   BioAv↝, 20,   BioEnh↑, 6,   CompStab↓, 1,   CompStab↑, 3,   CYP2E1↓, 2,   Dose↑, 1,   Dose⇅, 1,   Dose↝, 31,   eff↓, 1,   eff↑, 16,   eff↝, 1,   GSTA1↑, 3,   Half-Life↓, 4,   Half-Life↑, 3,   Half-Life↝, 12,   P-gp/ABCB1↓, 2,   P450↓, 1,   P450↝, 1,   Synergy↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   ALB↑, 1,   ALP↓, 1,   AST↓, 18,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 2,   BP↓, 9,   p‑BRCA1↑, 1,   Calcium↑, 1,   CK/CK-MB↓, 1,   creat↓, 3,   CRP↓, 7,   EGFR↓, 2,   IL6↓, 85,   IL6↑, 2,   LDH↓, 8,   LDH↑, 1,   Mag↑, 1,   NOS2↓, 5,   PSA↓, 1,   RAGE↓, 1,   TG/TAG↓, 1,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 16,   AntiArt↑, 4,   AntiCan↑, 11,   AntiDiabetic↑, 12,   AntiTum↑, 1,   cardioP↓, 1,   cardioP↑, 50,   cardioP⇅, 1,   chemoP↑, 5,   chemoPv↑, 3,   cognitive↑, 45,   cognitive↝, 1,   cough?, 1,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 35,   Learn↑, 5,   memory↑, 42,   Mood↑, 2,   motorD↑, 6,   neuroP↑, 99,   NP/CIPN↓, 2,   Obesity↓, 6,   OS↑, 4,   Pain↓, 10,   QoL↑, 1,   radioP↑, 3,   RenoP↓, 1,   RenoP↑, 16,   Sleep↑, 2,   SoreThr?, 1,   Strength↑, 2,   Stress↓, 1,   Stroke↓, 6,   toxicity↓, 19,   toxicity↑, 2,   toxicity↝, 5,   toxicity∅, 3,   Weight↓, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 2,   AntiP↑, 1,   AntiViral↑, 1,   Bacteria↓, 8,   Bacteria↑, 1,   Diar↓, 1,   GutMicro↑, 15,   Inf↓, 1,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr↝, 5,   Phen↑, 1,   QC↑, 1,  
Total Targets: 490

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
11 Thymoquinone
10 Curcumin
8 isoorientin
8 Quercetin
6 Carvacrol
6 Chrysin
6 Luteolin
6 Lycopene
5 Beta-Caryophyllene
5 Eugenol
5 Resveratrol
5 Silymarin (Milk Thistle) silibinin
4 Baicalein
4 Capsaicin
4 Ferulic acid
4 Magnetic Fields
4 Propolis -bee glue
3 Apigenin (mainly Parsley)
3 Aspirin
3 α-Bisabolol / Chamomile oil
3 Chlorogenic acid
3 Cichoric acid / Chicoric acid
3 Echinacea
3 Diclofenac
3 Ginger/6-Shogaol/Gingerol
3 Kaempferol
3 Licorice
3 Piperine
3 Rosmarinic acid
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 Alpha-Lipoic-Acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Radiotherapy/Radiation
2 Betulinic acid
2 Boron
2 Boswellia (frankincense)
2 buckwheat sprouts
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fisetin
2 Honokiol
2 Hyperoside
2 Isovitexin
2 Vitexin
2 Lemon Balm/Melissa officinalis
2 doxorubicin
2 Mushroom Lion’s Mane, Hericium erinaceus
2 Pterostilbene
2 Urolithin
2 Vitamin K2
1 acetaminophen
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Aloe anthraquinones
1 Baicalin
1 Biochanin A
1 xanthohumol
1 Cannabidiol
1 Black Rice, Oryza sativa
1 Carnosic acid
1 Celastrol
1 Crocetin
1 Lecithin
1 Chemotherapy
1 Date Fruit Extract
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Diindolylmethane
1 D-limonene
1 Dandelion Root
1 flavonoids
1 Formononetin
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Geraniol
1 Siegesbeckia glabrescens
1 Hops (Humulus lupulus)
1 Isorhamnetin
1 L-Theanine
1 lambertianic acid
1 Lemongrass Extract/Citral
1 Linalool
1 Lutein
1 Magnolol
1 Magnetic Field Rotating
1 Morin
1 Methylsulfonylmethane
1 Neem
1 Nimbolide
1 Oleocanthal
1 Marjoram (Origanum majorana)
1 Oregano
1 Patchouli Oil (Pogostemon cablin)
1 Protocatechuic acid
1 Mung Bean Sprouts
1 Piperlongumine
1 Sesame seeds and Oil
1 Shikonin
1 Thymol-Thymus vulgaris
1 Vitamin B1/Thiamine
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:66  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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