γH2AX Cancer Research Results

γH2AX, gamma-H2AX: Click to Expand ⟱
Source:
Type:
γH2AX (gamma-H2AX) is a histone protein that plays a crucial role in the repair of DNA double-strand breaks (DSBs). It is a phosphorylated form of the H2AX protein, which is a component of chromatin.

γH2AX is often used as a biomarker for DNA damage and genomic instability. When DNA is damaged, the H2AX protein is phosphorylated, forming γH2AX, which recruits and activates DNA repair proteins to the site of damage.
γ-H2AX, a marker for DNA double-strand breaks.

Cancer cells often exhibit increased levels of γH2AX due to their high rate of DNA replication and repair errors.

Gamma-H2AX, on the other hand, refers to a phosphorylated form of H2AX.
Scientific Papers found: Click to Expand⟱
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓, *antiAll↑,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   ROS↓, 2,   SOD↑, 2,   TBARS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Casp9↓, 1,   p‑p38↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   Obesity↓, 1,   Stress↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 34

Scientific Paper Hit Count for: γH2AX, gamma-H2AX
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:667  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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