ALP Cancer Research Results

ALP, Alkaline Phosphatase: Click to Expand ⟱
Source:
Type: enzyme
ALP (Alkaline Phosphatase) is an enzyme found in the body, and elevated levels of ALP in the blood can be associated with various conditions, including cancer.
Elevated ALP: Bone, Liver, pancreatic, breast, CRC, Prostate, thyroid, kidney, GI, Neuroblastoma
Used as a clinical biomarker for Liver function
Scientific Papers found: Click to Expand⟱
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
6299- Cro,    Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *ALP↓, *MDA↓, *ROS↓, *Catalase↑, *SOD↑, *IL6↓, *IL1β↓, *TNF-α↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *hepatoP↑, *GSH↑,
6347- DRE,    Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure
- in-vivo, LiverDam, NA
*hepatoP↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓, *creat↓, *TOS↑,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,
7049- GA,    Pharmacological effects of gallic acid in health and diseases: A mechanistic review
- Review, Var, NA
*antiOx↑, *Inflam↓, *antiNeop↑, *cardioP↑, *Bacteria↓, *AST↓, *ALAT↓, *ALP↓, *lipid-P↓, *GSH↑, *Catalase↑, *GPx↑, *GSTs↑, *Urea↓, *creat↓, tumCV↓, TumCCA↑, i-Ca+2↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, MMP↓, ROS↑, MMPs↓, *GastroP↑, *hepatoP↑, *ROS↓, *AChE↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
3844- MO,    Review of the Safety and Efficacy of Moringa oleifera
- Review, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
3842- MO,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
8904- MOR,    A 13-week subchronic toxicity study of dietary administered morin in F344 rats
- in-vivo, Nor, NA
*Dose?, *ALAT↓, *ALP↓, *creat↑, *Urea↑, *toxicity↝,
8434- OM,    Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L
- Review, Var, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *AntiP↑, *AntiDiabetic↑, *AntiCan↑, *RenoP↑, *Inflam↓, *Analgesic↑, *antiPy↑, *antiM↑, *Ingr↝, *Ingr↝, *creat↓, *Urea↓, *uricA↓, *BUN↓, *ALAT↓, *AST↓, *ALP↓, *Catalase↑, *SOD↑, *GSTA1↑,
9058- PatchO,    Patchouli oil isolated from the leaves of Pogostemon cablin ameliorates ethanol-induced acute liver injury in rats via inhibition of oxidative stress and lipid accumulation
- in-vivo, LiverDam, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *LDH↓, *ROS↓, *TNF-α↓, *FFA/NEFA↓, *TG/TAG↓, *GSH↑, *GSR↑, *SOD↑, *GSH/GSSG↑, *AMPK↑, *PPARα↑, *CPT1A↑, *NF-kB↓, *SREBP1/SREBF1↓, *Fas↓, *SCD1↓, *lipid-P↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *Synergy↑, *BioEnh↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑, *antiAll↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑, *antiAll↑,
4757- Se,  Chemo,    The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
- Trial, Var, NA
Dose↝, *ALP↓, chemoP↑,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, Var, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
3572- TQ,    Enhanced oral bioavailability and hepatoprotective activity of thymoquinone in the form of phospholipidic nano-constructs
- in-vivo, Nor, NA
*BioAv↑, *hepatoP↑, *ALAT↓, *ALP↓, *AST↓,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   GSH↓, 3,   MDA↓, 1,   MDA↑, 1,   ROS↑, 6,   SOD↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 5,   BAX↑, 5,   Bcl-2↓, 4,   Bcl-2↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 3,   cl‑Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 2,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   p‑Akt↓, 1,   p‑cMET↑, 1,   EGFR↓, 2,   ERK↓, 2,   HRAS↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   mTOR↓, 3,   PI3K↓, 2,   RAS↑, 1,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 4,   cl‑PARP↑, 2,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK4↓, 1,   Ki-67↓, 2,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CD133↓, 1,   Ki-67↓, 2,   Nestin↓, 1,   Shh↓, 1,   TumCG↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

AXL↓, 1,   i-Ca+2↑, 1,   E-cadherin↓, 2,   E-cadherin↑, 1,   F-actin↓, 1,   KRAS↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MMPs↓, 3,   N-cadherin↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumMeta↓, 4,   Twist↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 5,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CXCR3↓, 1,   CXCR4↓, 1,   DR4↑, 1,   Inflam↓, 1,   NF-kB↓, 3,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 3,   Dose↝, 2,   eff↑, 3,   RadioS↑, 1,   selectivity↓, 1,   selectivity↑, 4,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   EGFR↓, 2,   KRAS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 2,   neuroP↑, 1,   OS↑, 2,   Weight↑, 1,  
Total Targets: 110

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   Bil↓, 3,   Catalase↑, 13,   GPx↓, 1,   GPx↑, 11,   GSH↑, 11,   GSH/GSSG↑, 1,   GSR↑, 5,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 12,   MDA↓, 5,   NQO1↑, 1,   NRF2↑, 6,   ROS↓, 14,   SOD↑, 14,   TAC↑, 1,   Thiols↑, 1,   TOS↑, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 22,   AMPK↑, 3,   CPT1A↑, 1,   FFA/NEFA↓, 1,   glucose↓, 1,   GSK‐3β↓, 1,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   SCD1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 2,   Casp9↓, 1,   Cyt‑c↓, 1,   Fas↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

IKKα↑, 1,   JNK↓, 1,   mTOR↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

COL3A1↓, 1,   p‑Rac1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL10↑, 2,   IL1β↓, 4,   IL6↓, 5,   Inflam↓, 9,   NF-kB↓, 4,   PGE2↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 3,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,   PPARα↑, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioEnh↑, 1,   Dose?, 1,   Dose↝, 2,   eff↑, 2,   GSTA1↑, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 22,   ALP↓, 24,   AST↓, 22,   BG↓, 1,   Bil↓, 3,   BUN↓, 2,   CEA↓, 1,   creat↓, 6,   creat↑, 1,   IL6↓, 5,   LDH↓, 4,   TG/TAG↓, 1,   Urea↓, 2,   Urea↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   antiAll↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 2,   antiM↑, 1,   antiNeop↑, 1,   antiPy↑, 1,   cardioP↑, 6,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 15,   memory?, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   Obesity↓, 1,   radioP↑, 1,   RenoP↑, 5,   toxicity↓, 4,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 116

Scientific Paper Hit Count for: ALP, Alkaline Phosphatase
3 Carvacrol
2 Boron
2 Selenium
2 Moringa oleifera
2 Selenium NanoParticles
1 Alpha-Lipoic-Acid
1 Curcumin
1 Berberine
1 Biochanin A
1 Thymol-Thymus vulgaris
1 Crocetin
1 Dandelion Root
1 Eugenol
1 Gallic acid
1 Honokiol
1 Morin
1 Marjoram (Origanum majorana)
1 Patchouli Oil (Pogostemon cablin)
1 Piperine
1 Rosmarinic acid
1 Chemotherapy
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:689  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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