LDL Cancer Research Results

LDL, LDL-cholesterol: Click to Expand ⟱
Source:
Type:
The relationship between LDL (low-density lipoprotein) cholesterol and cancer is a complex and evolving area of research. LDL cholesterol is often referred to as "bad" cholesterol because high levels are associated with an increased risk of cardiovascular diseases.

Protumorigenic: High levels of LDL cholesterol can promote tumor growth by providing lipids that are essential for cell membrane synthesis and energy production. Additionally, LDL can influence inflammation and angiogenesis, further supporting tumor development.
Antitumorigenic: Some studies suggest that lowering LDL cholesterol through lifestyle changes or medications (like statins) may have a protective effect against certain cancers, although the evidence is not uniform across all cancer types.
Scientific Papers found: Click to Expand⟱
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5354- AL,    Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
- Review, Var, NA
*LDL↓, *antiOx↑, AntiCan↑, *cardioP↑, *BP↓, *Weight↓, NK cell↑, *AntiDiabetic↑, *GSH↑,
236- AL,    Allicin: Chemistry and Biological Properties
- Analysis, Nor, NA
*GSH↓, *Bacteria↓, *LDL↓, *ROS↑, *NRF2↑, *cognitive↑, *memory↑, *BP↓, *RNS↓,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓, *antiAll↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7397- Amla,    Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study
- Trial, Nor, NA
*Dose↝, *other↑, *LDL↓, *HDL↑, *toxicity↑, *ROS↓,
7401- Amla,    The impact of Emblica Officinalis (Amla) on lipid profile, glucose, and C-reactive protein: A systematic review and meta-analysis of randomized controlled trials
- Review, Nor, NA
*CRP↓, *glucose↓, *LDL↓, Dose↑,
7409- Amla,    Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study
- Trial, Nor, NA
*HDL↑, *LDL↓, *ROS↓, *AntiAg↑, *TBARS↓, *Dose↝,
5445- ATV,    Atorvastatin
- Review, Nor, NA
*cardioP↑, *LDL↓, *HMG-CoA↓, *Half-Life↝, *BioAv↓, *Dose↝,
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
- Review, AD, NA
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE/β-secretase↓, *AChE↓, *Synergy↑,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
5514- bemA,    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Trial, Nor, NA
*ACLY↓, *LDL↓, *MusCon↓, Dose↝, cardioP↑,
5708- Brut,    Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers
- Review, Nor, NA
*Imm↑, *cardioP↑, *LDL↓, toxicity↓,
9265- BTB,    Cooked Black Turtle Beans Ameliorate Insulin Resistance and Restore Gut Microbiota in C57BL/6J Mice on High-Fat Diets
- in-vivo, Nor, NA
*other↝, *LDL↓, *TG/TAG↓, *IL4↝, *IL5↝, *IFN-γ↝, *TNF-α↝, *IRes↓, *GutMicro↑,
7960- BuckWS,    Tartary buckwheat sprout powder lowers plasma cholesterol level in rats
- in-vivo, Nor, NA
*LDL↓, *Dose↑, *cardioP↑,
7953- BuckWS,  RT,    Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid
- Review, Nor, NA
*GastroP↑, *hepatoP↑, *AntiDiabetic↑, *Inflam↓, *BioAv↓, *LDL↓, *Fenton↓, *AGEs↓, *GSH↑, *Dose↝,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2/PTGS2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑, *CompStab↑,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, Nor, NA
*LDL↓, *TC↓,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
7406- Chy,    Antiamnesic activity of an ayurvedic formulation chyawanprash in mice
- in-vivo, AD, NA
*Dose↝, *memory↑, *TBARS↓, *GSH↑, *ROS↓, *cognitive↑, *AntiAge↑, *hepatoP↑, *antiOx↑, *LDL↓, *Inflam↓, *other↝, *AChE∅,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2/PTGS2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
6169- Cin,    Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, IBD, NA
*neuroP↑, *AntiDiabetic↑, *tau↓, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *MDA↓, *GSH↓, *cardioP↑, *LDL↓, *HDL↑, *other↝, *TNF-α↓, *IL6↓, *MPO↓, *TLR4↓, *GutMicro↑, *lipid-P↓, *Wound Healing↑,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *Synergy↑, *LDL↓, *HDL↑, *Synergy↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
7420- CS,    Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*LDL↓, *HDL↑, Dose↝,
7422- CS,    Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
- Review, Nor, NA
*LDL↓, *TG/TAG↓, *HDL∅,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
9106- CV,    Effect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials
- Review, Nor, NA
*Dose↝, *TC↓, *LDL↓,
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
6715- dietF,    Are Fermented Foods Effective against Inflammatory Diseases?
- Review, Nor, NA
*Imm↑, *GastroP↑, *Inflam↓, AntiCan↑, *AntiBio↑, *hepatoP↑, *CD4+↑, *IFN-γ↓, *IL17↓, *GutMicro↑, *antiOx↑, *AST↓, *ALAT↓, *HDL↑, *LDL↓, *ROS↓, *lipid-P↓, *Inflam↓, *Aβ↓,
6716- dietF,    Current Research in Fermented Foods: Bridging Tradition and Science
- Review, Nor, NA
*GutMicro↑, *Inflam↓, *BP↓, *LDL↓, *HDL↑, *CRP↓, *IL6↓, *TNF-α↓, *Obesity↓, *AntiDiabetic↑, *cardioP↑, *GutMicro↑, *neuroP↑, *cognitive↑,
8624- dietKeto,    Impact of ketogenic diets on cancer patient outcomes: a systematic review and meta-analysis
- Review, Var, NA
*Weight↓, *Insulin↓, *glucose↓, *fatigue↓, *Sleep↑, *LDL↓, *TC↓, *BHB↑, *ketosis↑, eff↑, CRP↓, Inflam↓, angioG↓,
5069- dietSTF,    The Role of Intermittent Fasting in the Activation of Autophagy Processes in the Context of Cancer Diseases
- Review, Var, NA
Risk↓, ChemoSen↑, RadioS↑, *Dose↝, *Dose↝, *Dose↝, *LDL↓, *CRP↓, *TNF-α↓, TumAuto↓, GLUT1↓, GLUT2↓, glucose↓, IGF-1↓, Insulin↓, mTOR↓, mTORC1↓, AMPK↑, Warburg↓, OXPHOS↑, ROS↑, DNAdam↑, JAK1↓, STAT↓, TumCP↓, QoL↑,
5071- dietSTF,    Unraveling the impact of intermittent fasting in cancer prevention, mitigation, and treatment: A narrative review
- Review, Var, NA - Review, AD, NA
Risk↓, TumCMig↓, IGF-1↓, TumAuto↑, Inflam↓, ChemoSen↑, Apoptosis↑, chemoP↑, *glucose↓, *AntiDiabetic↑, *cardioP↑, *LDL↓, *BP↓, *neuroP↑, *cognitive↑, *memory↑, *OS↑, *QoL↑, Imm↑, TumCG↓, ChemoSideEff↓, QoL↑,
4254- EA,    Chronic administration of ellagic acid improved the cognition in middle-aged overweight men
- Human, Obesity, NA
*LDL↓, *HDL↑, *BDNF↑, *cognitive↑,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1/ATG6↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, Synergy↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP/DDIT3↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *Synergy↑, *BioAv↑, Synergy↑, ChemoSen↑, *toxicity↝,
5784- EGCG,    Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
- in-vivo, Nor, NA
*OS↑, *Inflam↓, *LDL↓, *AntiAge↑, *GSH↑, *SOD↑, *AMPKα↑, *Weight∅,
8315- FS,    Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen
- Trial, Pca, NA - Trial, BPH, NA
PSA↓, *LDL↓, *other↝, *other↓,
8584- FS,    Anti-Oxidant and Anti-Cancer Properties of Flaxseed
- Review, Nor, NA
*Ingr↝, *cardioP↑, *LDL↓, *lipidLev↓, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *Analgesic↑, *AntiArt↑, *CRP↓, *TNF-α↓, *Inflam↓, *toxicity↝, *neuroP↑, *Ingr↝, *Ingr↝, *AntiViral↑, Risk↓, *Ingr↝, *hs-CRP↓, *GutMicro↑, *TJ↑, *OCLN↝, *MLC2/MYL9↝, *VCAM-1↓, *Akt2↓, *IKKα↓, *NF-kB↓, Synergy↑, HER2/EBBR2↓, MAPK↓, PI3K↓, Akt↓, EGFR↓, TumCG↓, TumMeta↓, IGF-1↓, COX2/PTGS2↓, PGE2↓, CDK4↓, TNF-α↓, IL1β↓, lipid-P↑, P53↑, MDM2↑, cl‑Casp3↑, cl‑PARP↑, cl‑Casp7↑, BAX↑, Bcl-2↓, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Ki-67↓, CYP1A1↑, p38↑, ERK↑, Synergy↑, ChemoSen↑, *BioAv↑, eff↝, Ingr↝,
8579- FS,  IP6,    Flaxseed: a potential source of food, feed and fiber
- Review, Nor, NA - Review, IBD, NA
*Ingr↑, *AntiCan↑, *Ingr↑, *AntiCan↑, *eff↑, *LDL↓, *HDL∅, *antiOx↑, *lipid-P↓, Synergy↑, *other↝, *BioAv↝, *eff↑, *other↝, *other↝, *other↝, *other↝, *other↝, *CompStab↑,
8578- FS,    High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans
- Human, Nor, NA
*LDL↓, *Dose↝, *glucose↑,
8585- FS,    Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging
- Review, Nor, NA
*cardioP↑, *Obesity↓, *lipidLev↓, *BP↓, *Inflam↓, *CRP↓, *IL6↓, *ROS↓, *hepatoP↑, *Ingr↝, *GutMicro↑, *Dose↑, *Ingr↝, *Ingr?, *CompStab↝, *MDA↓, *hs-CRP↓, *TNF-α↓, *AntiDiabetic↑, *ALAT↓, *AST↓, *GGT/CD224↓, *TG/TAG↓, *LDL↓, *HDL∅, *TC↓, *glucose↓, *Insulin↓, *SIRT1↑, *Dose↝, *Dose?,
8586- FS,    The Role of Flaxseed in Improving Human Health
- Review, Nor, NA
*lipidLev↓, *BP↓, *HOMA↓, *AntiCan↑, *antiOx↑, *BioAv↑, *Ingr↑, *Ingr↝, *Ingr↝, *GutMicro↑, *CompStab↝, *TC↓, *TG/TAG↓, *LDL↓, *HDL↑, *BP↓, *AntiDiabetic↑, *AntiCan↑, TumCD↑, selectivity↑, TumCP↓, Apoptosis↑, DNAdam↑, i-ROS↑, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, ChemoSen↑, Synergy↑, *Inflam↓, *hs-CRP↓, *VCAM-1↓, *BDNF↑,
7104- GEN,    Efficacy and safety of short-term genistein intervention in patients with localized prostate cancer prior to radical prostatectomy: a randomized, placebo-controlled, double-blind Phase 2 clinical trial
- Trial, Pca, NA
Dose↝, PSA↓, *LDL↓,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,

Showing Research Papers: 1 to 50 of 84
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 84

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↑, 1,   lipid-P↑, 2,   NRF2↓, 1,   ROS↓, 2,   ROS↑, 6,   i-ROS↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   OXPHOS↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   FASN↓, 1,   glucose↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   APAF1↑, 1,   Apoptosis↑, 9,   BAD↑, 1,   Bak↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 2,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 3,   Casp9↑, 3,   Cyt‑c↑, 2,   Fas↑, 2,   IAP2/BIRC3↓, 1,   MDM2↑, 1,   p38↑, 1,   TumCD↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 6,   p‑Akt↓, 1,   EGFR↓, 2,   ERK↓, 2,   ERK↑, 1,   HER2/EBBR2↓, 1,   IGF-1R↑, 1,   JAK1↓, 1,   MAP2K1/MEK1↓, 1,   MAPK↓, 2,   mTOR↓, 2,   PI3K↓, 4,   PKCδ↓, 1,   RAS↓, 1,   Sp1/3/4↓, 1,   STAT↓, 1,   STAT3↓, 2,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   ATF4↑, 1,   EZH2↓, 1,   miR-124-3p↓, 1,   miR-25-5p↓, 1,   Myc↓, 1,   other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3B↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   P53↑, 3,   PARP↑, 2,   cl‑PARP↑, 2,   TP53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK2↑, 1,   CDK4↓, 4,   CDK6↓, 1,   CDK6↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 2,   P21↑, 2,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 4,   Ki-67↓, 2,   mTORC1↓, 1,   NOTCH3↓, 1,   TumCG↓, 6,   TumCP↓, 7,   Wnt↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 2,   EMT↓, 2,   MALAT1↓, 1,   MMP2↓, 2,   MMP9↓, 1,   MMP9↑, 1,   MMPs↓, 1,   Rho↓, 1,   Rho↝, 1,   Smad1↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumMeta↓, 2,   Zeb1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   Hif1a↓, 2,   NO↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT2↓, 1,   MMP↓, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IL1β↓, 1,   Imm↑, 2,   Inflam↓, 2,   NF-kB↓, 4,   NK cell↑, 2,   PGE2↓, 1,   PSA↓, 3,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 8,   CYP1A1↑, 1,   Dose↑, 1,   Dose↝, 5,   eff↑, 4,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 4,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,   EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 1,   Myc↓, 1,   PSA↓, 3,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 3,   cardioP↑, 1,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   PFS↑, 1,   QoL↑, 3,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 6,   Risk↑, 1,   toxicity↓, 1,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↝, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 175

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 39,   ARE↑, 1,   Bil↓, 1,   Catalase↑, 14,   Fenton↓, 1,   GPx↑, 14,   GPx1↑, 1,   GSH↓, 2,   GSH↑, 16,   GSTs↑, 3,   H2O2↓, 1,   HDL↓, 2,   HDL↑, 18,   HDL∅, 4,   HO-1↑, 6,   HO-2↓, 1,   lipid-P↓, 16,   MDA↓, 10,   MPO↓, 5,   NADH↓, 1,   NQO1↑, 3,   NRF2↑, 12,   RNS↓, 3,   ROS?, 1,   ROS↓, 37,   ROS↑, 1,   ROS⇅, 1,   mt-ROS↓, 2,   SOD↑, 17,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 3,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compII↑, 1,   compIII↑, 1,   Insulin↓, 2,   mtDam↓, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   adiP↓, 2,   adiP↑, 1,   ALAT?, 1,   ALAT↓, 7,   AMPK↑, 2,   p‑AMPK↑, 1,   ATP↑, 2,   BHB↑, 1,   CRM↑, 1,   FASN↓, 1,   FFA/NEFA↓, 2,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   Glycolysis↑, 1,   GSK‐3β↓, 2,   HK2↑, 1,   HMG-CoA↓, 2,   LDL↓, 84,   lipidLev↓, 4,   NADPH↓, 3,   PLA2↓, 1,   SCFAs↑, 1,   SIRT1↑, 5,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   Bcl-2↑, 1,   Casp12↓, 1,   Casp3↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 1,   p38↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 3,   Akt2↓, 1,   AMPKα↑, 1,   IKKα↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   MAPK↝, 1,   mTOR↓, 4,   mTOR↑, 1,   PI3K↑, 3,   PTEN↓, 2,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   FOXO3↑, 1,   HDAC?, 1,   HDAC↓, 1,   other↓, 4,   other↑, 7,   other↝, 15,   other∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   NQO2↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   CHIP↑, 1,   HMGCR↓, 1,   IGF-1↑, 1,   IGFBP1↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 8,   AntiAg∅, 1,   Ca+2?, 1,   Ca+2↝, 1,   MLC2/MYL9↝, 1,   MMP9↓, 1,   MMPs↓, 2,   MUC1↑, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

E-sel↓, 1,   NO↓, 8,   TXA2↓, 1,   VCAM-1↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB↝, 1,   GastroP↑, 6,   GLUT4↑, 1,   IBI↑, 2,   ketosis↑, 1,   MMP↑, 2,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPV3↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2,   COX1↓, 2,   COX2/PTGS2↓, 8,   ICAM-1↓, 1,   IFN-γ↓, 3,   IFN-γ↑, 1,   IFN-γ↝, 1,   IL10↑, 2,   IL17↓, 3,   IL1β↓, 11,   IL23↓, 2,   IL4↓, 2,   IL4↑, 1,   IL4↝, 1,   IL5↝, 1,   IL6↓, 12,   IL8↓, 1,   Imm↑, 4,   Inflam↓, 40,   Inflam↑, 2,   LPS↓, 1,   MCP1/CCL2↓, 3,   NeuroI↓, 1,   NF-kB↓, 12,   NK cell↑, 1,   NLRP3↓, 4,   PGE2↓, 1,   RAGE↓, 1,   TLR4↓, 3,   TNF-α↓, 18,   TNF-α↝, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 2,   AChE↓, 10,   AChE∅, 1,   ADAM10↑, 1,   BChE↓, 4,   BDNF↑, 7,   ChAT↑, 1,   MAOA↓, 1,   MAOB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 11,   Aβ42↓, 1,   BACE/β-secretase↓, 4,   tau↓, 5,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   PPARα↑, 2,   PPARγ↓, 1,   PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 12,   BioAv↝, 7,   BioEnh↑, 2,   CompStab↑, 2,   CompStab↝, 2,   Dose?, 1,   Dose↑, 2,   Dose↝, 24,   eff↓, 4,   eff↑, 10,   eff↝, 1,   Half-Life↑, 2,   Half-Life↝, 2,   Synergy↑, 7,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 7,   ALP↓, 1,   AST↓, 7,   BG↓, 1,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 1,   BP↓, 12,   BP↝, 1,   creat↓, 1,   CRP↓, 8,   Ferritin↑, 1,   HOMA↓, 1,   hs-CRP↓, 3,   IL6↓, 12,   IRes↓, 2,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 11,   TG/TAG↓, 13,   Urea↓, 1,   VLDL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 5,   antiAll↑, 4,   AntiArt↑, 3,   AntiCan↑, 7,   AntiDiabetic↑, 17,   antiPs↑, 1,   AntiTum↑, 1,   BOLD↑, 1,   BowelM↑, 1,   cardioP↑, 29,   chemoP↑, 1,   cognitive↑, 19,   diuretic↑, 1,   fatigue↓, 1,   hepatoP↑, 16,   memory↑, 13,   motorD↑, 1,   MusCon↓, 1,   neuroP↑, 23,   Obesity↓, 9,   OS↑, 3,   QoL↑, 2,   RenoP↑, 5,   Risk↓, 3,   Risk↑, 1,   Sleep↑, 1,   Strength↑, 1,   Stress↓, 1,   Stroke↓, 2,   toxicity↓, 8,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 4,   Weight↓, 3,   Weight↝, 1,   Weight∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 3,   AntiFungal↑, 1,   AntiViral↑, 4,   Bacteria↓, 6,   GutMicro↑, 16,   Sepsis↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 3,   Ingr↑, 3,   Ingr↝, 10,  
Total Targets: 285

Scientific Paper Hit Count for: LDL, LDL-cholesterol
6 Flaxseed/Linseed
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 EGCG (Epigallocatechin Gallate)
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Allicin (mainly Garlic)
3 Curcumin
3 Hydrogen Gas
3 Vitamin B5,Pantothenic Acid
2 Berberine
2 buckwheat sprouts
2 Rutin
2 chitosan
2 Cinnamon
2 Chlorella (Chlorella vulgaris)
2 diet Fermented Foods
2 diet Short Term Fasting
2 Hibiscus sabdariffa
2 Lycopene
2 Psyllium husk
1 Anthocyanins
1 Atorvastatin
1 Huperzine A/Huperzia serrata
1 bempedoic acid
1 Bruteridin(bergamot juice)
1 Black turtle bean
1 Carvacrol
1 Chocolate
1 Chyawanprash
1 Coenzyme Q10
1 Selenium
1 Spirulina(Arthrospira/Limnospira)
1 diet Ketogenic
1 Ellagic acid
1 phytic acid, Inositol hexakisphosphate
1 Genistein (soy isoflavone)
1 Ginger/6-Shogaol/Gingerol
1 Inositol
1 isoflavones
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 lambertianic acid
1 Lecithin
1 Lactoferrin/Talactoferrin
1 Mung Bean Sprouts
1 Metformin
1 Moringa oleifera
1 Nimbolide
1 Phenylbutyrate
1 Pterostilbene
1 Quercetin
1 Resveratrol
1 Salvia officinalis
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Thymoquinone
1 Thymol-Thymus vulgaris
1 Urolithin
1 Vitamin E
1 Walnut
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:71  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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