MMP3 Cancer Research Results

MMP3, Matrix metalloproteinase-3: Click to Expand ⟱
Source:
Type:
MP-3: also known as stromelysin-1, is a type of enzyme that plays a crucial role in the degradation of the extracellular matrix (ECM).
MMP-3 can break down the ECM, allowing cancer cells to invade surrounding tissues and form new tumors.
High levels of MMP-3 expression are associated with poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
733- Bor,    The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells
- in-vitro, Lung, NA
Snail↑, ITGB1↑, ITGA5↑, COL1A1↓, LAMA5↑, MMP3↓, Vim↓, E-cadherin↑, EMT↓, Zeb1↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
5897- CAR,    Carvacrol Selectively Induces Mitochondria-Related Apoptotic Signaling in Primary Breast Cancer-Associated Fibroblasts
- in-vitro, BC, NA
Bax:Bcl2↑, PPARα↓, NF-kB↓, SIRT1↑, SIRT3↑, MMP3↓, selectivity↑, Bcl-2↓, BAX↑, Casp3↑, Casp6↑, Casp9↑, mt-Apoptosis↑,
6204- Cuc,    Preliminary investigation of the anti-colon cancer activity of cucurbitacin C from cucumber: A network pharmacological study and experimental validation
- in-vitro, Colon, HCT116
TumCP↓, TumCMig↓, TumCG↓, MMP1↓, MMP3↓, MMP9↓, MMP13↓, Apoptosis↑,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
6827- EMD,    Mechanism of Emodin in the Treatment of Rheumatoid Arthritis
- Review, Arthritis, NA
*ALAT↓, *AST↓, *ROS↓, *cardioP↑, *TNF-α↓, *NF-kB↓, *Inflam↓, *AntiArt↑, *PGE2↓, *MMP3↓, *MMP13↓, *COX2/PTGS2↓, *AntiCan↑, *neuroP↑, *hepatoP↑,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
7086- GAR,    Garcinol: An emerging epigenetic modifier with versatile anticancer properties
- Review, Var, NA
AntiCan↑, TumCG↓, TumMeta↓, toxicity↓, Apoptosis↑, angioG↓, *BioAv↝, HATs↓, p300↓, CBP↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, mTOR↓, DFF45↓, survivin↓, N-cadherin↓, Twist↓, MMP2↓, MMP3↓, MMP9↓, Mcl-1↓, EZH2↓, NOTCH↓, CXCR4↓, PGE2↓, VEGF↓, mPGES-1↓, CycB/CCNB1↓, CDK2↓, CDK4/6↓, iNOS↓, COX2/PTGS2↓, IL1↓, TNF-α↓, PARP↑, Bcl-2↓,
7695- IP6,    The effect of inositol hexaphosphate on the expression of selected metalloproteinases and their tissue inhibitors in IL-1β-stimulated colon cancer cells
- in-vitro, Colon, Caco-2
AntiCan↑, TumCA↓, TumCMig↓, MMP13↓, MMP3↓, MMP2↓, TIMP1↓, MMP1↓, MMP9↓, TIMP2↓,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8251- LCA,    Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression
- in-vitro, Lung, A549 - in-vitro, Lung, H460
TumCMig↓, TumCI↓, MMP1↓, MMP3↓, p‑Akt↓, Akt↓, Sp1/3/4↓,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, FOXM1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
2341- QC,    Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
MMP2↓, MMP9↓, VEGF↓, Glycolysis↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, TumAuto↑, Akt↓, mTOR↓, TumMeta↓, MMP3↓, eff↓, GlucoseCon↓, lactateProd↓, TumAuto↑, LC3B-II↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
2360- SK,    Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the phosphatidylinositol 3 kinase/AKT signal pathway
- in-vitro, NPC, HONE1 - in-vitro, NPC, SUNE-1
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, PI3K↓, Akt↓, MMP3↓, MMP9↓, TIMP1↑,

Showing Research Papers: 1 to 22 of 22

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 22

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,   ATG13↑, 1,   ATG16L1↑, 1,   RUBCN↓, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSTs↓, 1,   HO-1↑, 2,   Keap1↓, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 4,   ROS↓, 1,   ROS↑, 9,   SIRT3↑, 1,   SOD↑, 1,   Trx↓, 1,   TrxR1↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   CDC2↓, 1,   CDC25↓, 4,   EGF↓, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 5,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↓, 1,   AMPK↑, 2,   ATG7↑, 1,   cMyc↓, 1,   FGF21↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 3,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 2,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   p‑Akt↓, 3,   APAF1↑, 2,   Apoptosis↑, 6,   mt-Apoptosis↑, 2,   BAD↑, 2,   BAX↑, 7,   Bax:Bcl2↑, 2,   Bcl-2↓, 8,   Bcl-xL↓, 2,   BIM↑, 2,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp6↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 1,   CBP↓, 1,   Cyt‑c↑, 6,   Diablo↑, 2,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   IAP1↓, 1,   ICAD↓, 1,   iNOS↓, 3,   JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 4,   MDM2↓, 2,   Myc↓, 1,   p38↓, 1,   p38↑, 1,   survivin↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

SOX9↓, 1,   Sp1/3/4↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   EZH2↓, 1,   HATs↓, 1,   other↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 3,   eIF2α↓, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 4,   P53?, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 6,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21↑, 2,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   cFos↓, 1,   p‑cMET↑, 1,   CSCs↓, 1,   EMT↓, 3,   EMT↑, 1,   ERK↓, 3,   p‑ERK↓, 1,   ERK5↓, 1,   FOXM1↓, 2,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 8,   NOTCH↓, 1,   p300↓, 1,   P70S6K↓, 1,   PI3K↓, 8,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   TOP2↓, 1,   TumCG↓, 2,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↑, 2,   cal2↓, 1,   CD31/PECAM-1↓, 1,   CDK4/6↓, 1,   COL1A1↓, 1,   E-cadherin↑, 4,   FAK↓, 1,   Fibronectin↓, 1,   ITGA5↑, 1,   ITGB1↑, 1,   Ki-67↓, 1,   LAMA5↑, 1,   MET↓, 1,   MMP-10↓, 1,   MMP1↓, 6,   MMP13↓, 5,   MMP2↓, 6,   MMP3↓, 17,   MMP7↓, 2,   MMP9↓, 11,   MMPs↓, 1,   N-cadherin↓, 4,   PKCδ↓, 2,   Rho↓, 1,   ROCK1↓, 1,   Snail↓, 1,   Snail↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 6,   TumCMig↓, 6,   TumCP↓, 5,   TumMeta↓, 5,   Twist↓, 2,   uPA↓, 2,   Vim↓, 4,   Zeb1↓, 1,   Zeb1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   ATF4↓, 1,   ATF4↑, 1,   EGFR↓, 4,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 3,   NO↓, 2,   VEGF↓, 10,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL1↓, 2,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 7,   NF-kB↑, 1,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 5,   Dose↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 2,   BMPs↑, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 2,   GutMicro↑, 1,   IL6↓, 2,   Ki-67↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 2,   neuroP↑, 1,   OS↑, 1,   PRAS40↑, 1,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 1,  
Total Targets: 261

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 1,   HO-1↑, 3,   lipid-P↓, 2,   NRF2↑, 3,   ROS↓, 8,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   GlutMet↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Casp1↓, 1,   Casp3↓, 2,   iNOS↓, 2,   p‑JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   GSK‐3β↑, 1,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   MMP13↓, 1,   MMP2↓, 1,   MMP3↓, 5,   MMP9↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   NO↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 4,   IL8↓, 1,   Inflam↓, 4,   IκB?, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   PGE2↓, 5,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   cardioP↑, 2,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 5,   toxicity∅, 1,  
Total Targets: 69

Scientific Paper Hit Count for: MMP3, Matrix metalloproteinase-3
2 Emodin
2 Fisetin
2 Licochalcone A
2 Resveratrol
1 Berberine
1 Bacopa monnieri
1 Boron
1 Boswellia (frankincense)
1 Carvacrol
1 Cucurbitacin
1 Curcumin
1 Garcinol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Kaempferol
1 Licorice
1 Piperlongumine
1 Quercetin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:757  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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