MMP3 Cancer Research Results

MMP3, Matrix metalloproteinase-3: Click to Expand ⟱
Source:
Type:
MP-3: also known as stromelysin-1, is a type of enzyme that plays a crucial role in the degradation of the extracellular matrix (ECM).
MMP-3 can break down the ECM, allowing cancer cells to invade surrounding tissues and form new tumors.
High levels of MMP-3 expression are associated with poor prognosis in various types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
5483- BM,    The Role of Bacopa monnieri in Alzheimer’s Disease: Mechanisms and Potential Clinical Use—A Review
- Review, AD, NA
*cognitive↑, *neuroP↑, *PI3K↑, *Akt↑, *GSK‐3β↓, *tau↓, *ROS↓, *MMP3↓, *Casp1↓, *Casp3↓, *NF-kB↓, *TNF-α↓, *IL6↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
6827- EMD,    Mechanism of Emodin in the Treatment of Rheumatoid Arthritis
- Review, Arthritis, NA
*ALAT↓, *AST↓, *ROS↓, *cardioP↑, *TNF-α↓, *NF-kB↓, *Inflam↓, *AntiArt↑, *PGE2↓, *MMP3↓, *MMP13↓, *COX2/PTGS2↓, *AntiCan↑, *neuroP↑, *hepatoP↑, *antiAll↑,
9292- MF,    Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL-1β-Conditioned Environment
- in-vivo, Nor, NA
*other↝, *Dose↝, *IL6↓, *TNF-α↓, *IL8↓, *COX2/PTGS2↓, *MMP-10↓, *MMP2↓, *MMP3↓, *IL4↑, *IL10↑, *TIMP1↑, *Inflam↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   DR5↑, 1,   ICAD↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   p‑ERK↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXM1↓, 1,   SOX9↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CDK1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   p‑RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,  

Migration(tgid=13) ⓘ

cal2↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   FOXM1↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 40

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   HO-1↑, 1,   ROS↓, 4,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 2,   ALAT↓, 1,   AMPK↑, 1,   GlutMet↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Casp1↓, 1,   Casp3↓, 2,   iNOS↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑JNK↓, 1,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,  

Migration(tgid=13) ⓘ

MMP-10↓, 1,   MMP13↓, 1,   MMP2↓, 2,   MMP3↓, 6,   MMP9↓, 2,   TIMP1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 3,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IL1↓, 1,   IL10↑, 1,   IL12↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 4,   IL8↓, 2,   Inflam↓, 3,   MCP1/CCL2↓, 1,   NF-kB↓, 4,   NLRP3↓, 1,   PGE2↓, 4,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TNF-α↓, 5,  

Protein Aggregation(tgid=19) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 4,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   toxicity∅, 1,  
Total Targets: 68

Scientific Paper Hit Count for: MMP3, Matrix metalloproteinase-3
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Curcumin
1 Emodin
1 Magnetic Fields
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:757  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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