MIP2 Cancer Research Results

MIP2, Macrophage Inflammatory Protein 2: Click to Expand ⟱
Source:
Type: chemokine
Macrophage Inflammatory Protein 2 (MIP-2) is a chemokine that plays a role in the recruitment of immune cells to sites of inflammation.
MIP-2 is produced by various cell types, including macrophages, epithelial cells, and cancer cells themselves. It acts by binding to its receptors, CXCR1 and CXCR2, which are expressed on the surface of immune cells, such as neutrophils and macrophages.
Scientific Papers found: Click to Expand⟱
3667- ART/DHA,    Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia
- Review, Sepsis, NA
*cognitive↑, *neuroP↑, *TNF-α↓, *IL6↓, *NF-kB↓, *AMPK↑, *ROS↓, *Akt↑, *MCP1/CCL2↓, *MIP2↓, *TGF-β↑, *Inflam↓,
7140- GI,    Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes
- Review, Var, NA
*Dose↝, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *MAPK?, *HO-1↑, *PGE2↓, *TNF-α↓, *IL6↓, *IL1β↓, *IFN-γ↓, *MCP1/CCL2↓, *MIP2↓, *RANTES↓, *MPO↓, *NO↓, *Stroke↓, *BrainVol↑, *MDA↓, *ROS↓, *GSH↑, *NRF2↑, *antiOx↑, NLRP3↓, HDAC1↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

HDAC1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NLRP3↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GCLC↝, 1,   GCLM↝, 1,   GSH↑, 1,   HO-1↑, 2,   Keap1↝, 1,   MDA↓, 1,   MPO↓, 1,   NQO1↝, 1,   NRF2↑, 2,   ROS↓, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   MAPK?, 1,  

Migration(tgid=13) ⓘ

TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL1β↓, 2,   IL6↓, 3,   Inflam↓, 3,   MCP1/CCL2↓, 2,   MIP2↓, 3,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   RANTES↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BrainVol↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Stroke↓, 1,  
Total Targets: 40

Scientific Paper Hit Count for: MIP2, Macrophage Inflammatory Protein 2
1 Artemisinin
1 Ginger/6-Shogaol/Gingerol
1 Isoliquiritigenin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:788  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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