ACSL4 Cancer Research Results
ACSL4, Acyl-CoA Synthetase Long-Chain Family Member 4: Click to Expand ⟱
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ACSL4 (Acyl-CoA Synthetase Long-Chain Family Member 4) is a protein that plays a crucial role in the regulation of fatty acid metabolism, particularly in the context of cancer.
ACSL4 has been shown to be highly expressed in various types of cancer.
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Scientific Papers found: Click to Expand⟱
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
*ROS↓, *MDA↓, *LDH↑, *SOD↑, *Catalase↑, *NRF2↑, *i-Iron↓, *GPx4↑, *xCT/SLC7A11↑, *lipid-P↓, *Ferroptosis↓, *HO-1↑, *ACSL4↓, *mtDam↓, *Stroke↓,
TumCP↓, Apoptosis↑, Casp↑, mtDam↑, MMPs↓, VEGF↓, EMT↓, *antiOx↓, *Inflam↓, *ROS↓, MDR1↓, PI3K↓, Akt↓, MAPK↓, NF-kB↓, Ingr↝, TumCCA↑, CycB/CCNB1↓, CDK1↓, P21↑, ROS↑, AMPK↑, *Ferroptosis↓, *NRF2↑, *HO-1↑, *IronCh↑, *lipid-P↓, *GSH↑, *ACSL4↓, *COX2/PTGS2↓, VEGF↓, angioG↓, E-cadherin↑, N-cadherin↓, uPA↓, *NK cell↑, radioP↑, Imm↑, Neut↑, Eos↑,
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
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in-vivo, |
Nor, |
NA |
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- |
in-vivo, |
Stroke, |
NA |
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*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
Showing Research Papers: 1 to 5 of 5
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
ROS↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
mtDam↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
AMPK↑, 1,
Cell Death(tgid=5) ⓘ
Apoptosis↑, 1, Casp↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
Akt↓, 1, MAPK↓, 1, PI3K↓, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK1↓, 1, CycB/CCNB1↓, 1, P21↑, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
TumCP↓, 1,
Migration(tgid=13) ⓘ
E-cadherin↑, 1, EMT↓, 1, MMPs↓, 1, N-cadherin↓, 1, uPA↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
angioG↓, 1, VEGF↓, 2,
Immune & Inflammatory Signaling(tgid=16) ⓘ
Eos↑, 1, Imm↑, 1, Neut↑, 1, NF-kB↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
MDR1↓, 1,
Functional Outcomes(tgid=23) ⓘ
radioP↑, 1,
Ingredients & Constituents(tgid=25) ⓘ
Ingr↝, 1,
Total Targets: 27
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
4-HNE↓, 1, antiOx↓, 1, antiOx↑, 1, Catalase↑, 1, GPx↑, 1, GPx4↑, 4, GSH↑, 2, HO-1↑, 2, Iron↓, 1, i-Iron↓, 2, lipid-P↓, 2, MDA↓, 2, NRF2↑, 3, ROS↓, 3, SOD↑, 2, xCT/SLC7A11↑, 1,
Metal & Cofactor Biology(tgid=2) ⓘ
Ferritin↑, 1, IronCh↑, 2, TfR1/CD71↓, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
mtDam↓, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
ACSL4↓, 5,
Cell Death(tgid=5) ⓘ
Apoptosis↓, 2, BAX↓, 1, Bcl-2↑, 1, Ferroptosis↓, 5, p38↓, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
ERK↓, 1, JNK↓, 1,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 1, BBB↝, 1, CLDN4↑, 1, OCLN↑, 1, TJ↑, 1, ZO-1↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2/PTGS2↓, 1, HMGB1↓, 1, IL1β↓, 1, IL6↓, 1, Inflam↓, 2, NF-kB↓, 1, NK cell↑, 1, RAGE↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
Dose?, 1,
Clinical Biomarkers(tgid=22) ⓘ
Ferritin↑, 1, IL6↓, 1, LDH↑, 1, RAGE↓, 1,
Functional Outcomes(tgid=23) ⓘ
cardioP↑, 1, neuroP↑, 2, Stroke↓, 2,
Total Targets: 51
Scientific Paper Hit Count for: ACSL4, Acyl-CoA Synthetase Long-Chain Family Member 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:1 prod#:% Target#:867 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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