Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
6474- 1,8-Cin,    Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation
- in-vitro, Nor, HT29 - in-vivo, Nor, NA - in-vivo, IBD, NA
*Inflam↓, *NRF2↑, *antiOx↑, *PPARγ↑, eff↑,
6472- 1,8-Cin,    Protective Effects of 1,8-Cineole Microcapsules Against Inflammation and Gut Microbiota Imbalance Associated Weight Loss Induced by Heat Stress in Broiler Chicken
- in-vivo, Nor, NA
*Inflam↓, *GutMicro↑,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
5289- 5-HTP,    5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology
- Review, AD, NA - Review, Arthritis, NA
*5HT↑, *Inflam↓, *memory↑, *Sleep↑, *Weight↓, *DNAdam↓, *ROS↓, *toxicity↝,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
3971- ACNs,    Blueberry Supplementation Improves Memory in Older Adults
- Human, AD, NA
*antiOx↑, *Inflam↓, *memory↑, *neuroP↑, *cognitive↑, *Mood↑, *glucose↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5976- AgNPs,    Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions
- Review, Vit, NA
*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, Synergy↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,
4549- AgNPs,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
4418- AgNPs,    Nanocarriers for the topical treatment of psoriasis - pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology
- Human, PSA, NA
*Inflam↓, *EPR↑,
4360- AgNPs,    Silver Nanoparticles as Real Topical Bullets for Wound Healing
- Study, Nor, NA
*other↝, *toxicity↓, *eff↑, *eff↑, *Inflam↓, *IL6↓, *TGF-β↑, *MMP9↓, *eff↑,
4434- AgNPs,  SSE,    Sodium Selenite Ameliorates Silver Nanoparticles Induced Vascular Endothelial Cytotoxic Injury by Antioxidative Properties and Suppressing Inflammation Through Activating the Nrf2 Signaling Pathway
- vitro+vivo, Nor, NA
*ROS↓, *Inflam↓, *NLRP3↓, *NF-kB↓, *NRF2↑, *HO-1↑, *toxicity↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
4364- AgNPs,    Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties
- in-vitro, BC, MCF7
TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
5352- AL,    Anticancer potential of allicin: A review
- Review, Var, NA
*cardioP↑, *Bacteria↓, *Inflam↓, AntiTum↑, *DNAdam↓, TumCP↓, angioG↓, TumMeta↓,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓, *antiAll↑,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3445- ALA,  Rad,    The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *Synergy↑, *memory↑, *motorD↑, *GutMicro↑,
3447- ALA,    Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells
- in-vitro, AD, SH-SY5Y
*ATP↑, *MMP↑, *ROS↓, *GlucoseCon↑, *GSH↑, *neuroP↑, *cognitive↑, *Ach↑, *Inflam↓, *Aβ↓, OXPHOS↓,
3448- ALA,    Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line
- in-vitro, Nor, NA
*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3551- ALA,    Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *Inflam↓, *antiOx↑, *BioAv↝, *neuroP↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3543- ALA,    The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
- Study, AD, NA
*cognitive↑, *antiOx↑, *Inflam↓, *neuroP↑, *Ach↑, *ROS↓, *GlucoseCon↑, *lipid-P↓, *GSH↑, *Acetyl-CoA↑,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
4282- ALA,    Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial
- Trial, Var, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *adiP↑, *cognitive∅, *BDNF↑,
5324- ALC,    The anti-wasting effects of L-carnitine supplementation on cancer: experimental data and clinical studies
- Review, Var, NA
*cachexia↓, *Apoptosis↓, *Inflam↓, QoL↑, Dose↝, Weight↑, OS↝, fatigue↓, eff↝,
5262- aLinA,    The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review
- Review, AD, NA
*neuroP↑, *Risk↓, *cognitive↑, *Inflam↓, *antiOx↑, *BDNF↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7402- Amla,    Traditional knowledge to clinical trials: A review on therapeutic actions of Emblica officinalis
- Review, Var, NA
*Synergy↑, *antiOx↑, *AntiCan↑, *Imm↑, *Inflam↓, *AntiArt↑, *Dose↝, *VitC↑, radioP↑, *cardioP↑, *GastroP↑, *Wound Healing↑, *Diar↓, eff↑, NK cell↑, BAX↑, Bcl-2↓, TumCCA↑, Dose↝,
6398- ANE,    trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells
- in-vitro, OS, MG63
*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↓, *PI3K↑, *Akt↑, *mTOR↑,
6402- ANE,  FEO,    trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel
- in-vitro, Nor, HEK293
*TRPA1↑, *Dose↝, *Bacteria↓, *Inflam↓,
3886- Api,    Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
- in-vitro, AD, NA
*Inflam↓, *neuroP↑, *NO↓, *Apoptosis↓,

Showing Research Papers: 1 to 50 of 1066
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1066

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   antiOx⇅, 2,   Catalase↓, 5,   Catalase↑, 3,   Fenton↑, 1,   GPx↑, 1,   GPx4↓, 4,   GSH↓, 17,   GSH↑, 2,   GSR↑, 1,   GSTs↑, 3,   H2O2↓, 1,   H2O2↑, 4,   HO-1↓, 2,   HO-1↑, 9,   Iron↑, 4,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 11,   MDA↓, 4,   MDA↑, 8,   MPO↓, 1,   NADH↓, 2,   NOX4↑, 1,   NQO1↓, 1,   NQO1↑, 4,   NRF2↓, 12,   NRF2↑, 14,   ROS↓, 23,   ROS↑, 142,   ROS⇅, 4,   ROS↝, 1,   i-ROS↓, 1,   i-ROS↑, 3,   mt-ROS↑, 4,   SOD?, 1,   SOD↓, 4,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 1,   ac‑SOD2↓, 1,   Thiols↓, 2,   Trx↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC2↓, 2,   CDC25↓, 3,   compI↓, 2,   compII↓, 1,   compIV↓, 1,   ETC↓, 2,   HSP60/HSPD1↓, 1,   MFN2↑, 1,   mitResp↓, 1,   MKK7↓, 1,   mtDam?, 1,   mtDam↓, 1,   mtDam↑, 17,   OCR↓, 1,   OXPHOS↓, 3,   PDH↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SDH↓, 1,   SIRT3↓, 1,   SIRT3↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 4,   ACC1↓, 1,   Acetyl-CoA↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 11,   AMPK↝, 1,   p‑AMT/GCST/T-protein↑, 1,   ATGL/PNPLA2↓, 1,   ATP↓, 13,   mt-ATP↓, 1,   BHB↑, 1,   CAIX/CA9↓, 2,   CRM↑, 1,   DHODH↓, 1,   ENO1↓, 1,   FASN↓, 7,   FFA/NEFA↓, 1,   G6PD↓, 1,   GLS↓, 1,   glucose↓, 2,   GlucoseCon↓, 6,   GlutMet↓, 2,   Glycolysis↓, 19,   Glycolysis↝, 1,   GSK‐3β↓, 7,   GSK‐3β↑, 6,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 5,   HK2↓, 9,   HMG-CoA↓, 1,   HMGCS2↑, 1,   HSL/LIPE↓, 1,   p‑HSL/LIPE↑, 1,   lactateProd↓, 6,   lactateProd↑, 1,   LDHA↓, 4,   LDL↓, 1,   MCT4↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 1,   NADPH↑, 1,   PCK1↓, 1,   PDK1 / PDPK1↓, 5,   PDK3↑, 1,   PFK↓, 1,   PKM2↓, 5,   PLA2↓, 1,   Pyruv↓, 1,   SCD1↓, 2,   SIRT1↓, 7,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,   SREBP2↓, 2,   TCA↓, 2,   Warburg↓, 5,  

Cell Death(tgid=5) ⓘ

AIF↑, 7,   APAF1↑, 5,   Apoptosis?, 3,   Apoptosis↓, 3,   Apoptosis↑, 158,   ASC↑, 1,   BAD↓, 1,   BAD↑, 5,   Bak↓, 1,   Bak↑, 3,   BAX↓, 3,   BAX↑, 69,   Bax:Bcl2↑, 12,   Bcl-2↓, 76,   Bcl-2↑, 3,   Bcl-xL↓, 11,   Bcl-xL↑, 1,   BID↑, 2,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 28,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp12↑, 3,   Casp3↓, 4,   Casp3↑, 94,   cl‑Casp3↑, 14,   cl‑Casp3⇅, 1,   proCasp3↓, 1,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 14,   cl‑Casp7↑, 5,   Casp8↓, 2,   Casp8↑, 25,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 61,   cl‑Casp9↑, 8,   CellShr↑, 1,   cFLIP↓, 4,   Cyt‑c↓, 2,   Cyt‑c↑, 61,   Diablo↑, 4,   DR5↓, 1,   DR5↑, 10,   DR5↝, 1,   Endon↑, 1,   FADD↑, 1,   Fap1↓, 1,   Fas?, 1,   Fas↓, 2,   Fas↑, 9,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 5,   GranB/GZMB↓, 1,   GranB/GZMB↝, 1,   GSDMD↑, 1,   IAP1↓, 5,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 10,   Mcl-1↓, 3,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   cl‑Mcl-1↑, 1,   MDM2↓, 3,   MDM2↑, 1,   p‑MDM2↓, 1,   MOMP↓, 1,   MOMP↑, 3,   Necroptosis↑, 2,   necrosis↑, 2,   p38↓, 4,   p38↑, 12,   p‑p38↓, 1,   p‑p38↑, 2,   Paraptosis↑, 1,   Perforin↝, 1,   pS2/TFF1↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 23,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↓, 2,   TumCD↑, 8,   XIAP↓, 15,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 102,   Akt↑, 6,   p‑Akt↓, 21,   AKT1↓, 1,   Akt2↓, 1,   CIP2A↓, 1,   CK2↓, 5,   cMET↓, 1,   p‑cMET↑, 1,   CREB↓, 1,   cSrc↓, 1,   EF-1α↓, 1,   EGFR↓, 22,   EGFR↑, 1,   ERK↓, 29,   ERK↑, 3,   p‑ERK↓, 9,   p‑ERK↑, 1,   FOXD3↑, 1,   HCAR2↑, 2,   HER2/EBBR2↓, 9,   HGF/c-Met↓, 2,   Hippo↑, 1,   IGF-1R↓, 2,   IGF-1R↑, 1,   IGFR↓, 1,   IKKα↓, 2,   JAK↓, 2,   JAK1↓, 2,   JAK1↑, 1,   JAK2↓, 8,   p‑JAK2↓, 1,   JAK3↓, 1,   JNK↓, 8,   JNK↑, 9,   p‑JNK↓, 2,   p‑JNK↑, 4,   LIMK1↓, 1,   MAPK↓, 22,   MAPK↑, 10,   MAPK↝, 1,   p‑MAPK↓, 1,   MARK4↓, 1,   MEK↓, 2,   MKK4↓, 1,   MKP1↝, 1,   mTOR↓, 55,   mTOR↝, 2,   p‑mTOR↓, 8,   mTORC2↓, 2,   p70S6↓, 1,   P70S6K↓, 3,   P90RSK↓, 1,   PDE3B↓, 1,   p‑PDGFR-BB↓, 1,   PI3K↓, 86,   PI3K↑, 1,   p‑PI3K↓, 4,   PIK3CA↓, 1,   PKA↓, 1,   p‑PKA↓, 1,   PKCδ↓, 6,   PTEN↓, 5,   PTEN↑, 17,   Raf↓, 2,   c-Raf↓, 1,   RAS↓, 5,   RAS↑, 1,   Rictor↓, 1,   RIP1↓, 1,   SHP1↑, 2,   Sp1/3/4↓, 7,   STAT↓, 3,   STAT3↓, 47,   STAT3↑, 1,   p‑STAT3↓, 6,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 8,   cJun↓, 3,   cJun↑, 1,   p‑cJun↑, 1,   cMyc↓, 21,   cMyc↑, 1,   DNMT1↓, 4,   DNMT3B↓, 2,   DNMTs↓, 5,   EZH2↓, 3,   FOXM1↓, 2,   FOXO1↓, 2,   FOXO1↑, 3,   FOXO3↓, 1,   FOXO3↑, 3,   FOXO3↝, 1,   FOXO4↓, 1,   FOXO4↑, 1,   H3↑, 1,   p‑H3↓, 1,   ac‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   HDAC↓, 13,   HDAC1↓, 6,   HDAC2↓, 3,   HDAC3↓, 4,   HDAC8↓, 1,   HES1↓, 2,   miR-106b↓, 1,   miR-124-3p↓, 1,   miR-143↑, 1,   miR-148a↑, 1,   miR-19b↓, 1,   miR-200b↑, 2,   miR-203↑, 1,   miR-21↓, 5,   miR-25-5p↓, 1,   miR-27a-3p↓, 2,   miR-34a↓, 2,   miR-34a↑, 3,   miR-590-3p↑, 1,   Myc↓, 3,   OCT4↓, 8,   other↓, 2,   other↑, 6,   other↝, 11,   PhotoS↑, 3,   sonoS↑, 1,   SOX2↓, 4,   SOX4↓, 2,   SOX9?, 1,   SUMO↓, 1,   tumCV?, 2,   tumCV↓, 36,   UTF1↑, 1,   ZBTB10↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 14,   cl‑CHOP/DDIT3↑, 1,   eIF2α↑, 5,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 29,   GRP78/BiP?, 1,   GRP78/BiP↓, 2,   GRP78/BiP↑, 7,   GRP78/BiP↝, 1,   HSP27↓, 4,   HSP70/HSPA5↓, 3,   HSP70/HSPA5↑, 2,   HSP72↓, 1,   HSP90↓, 5,   HSPs↓, 1,   HTRA↓, 1,   IRE1↑, 1,   p‑IRE1↓, 1,   NQO2↑, 1,   PERK↑, 7,   p‑PERK↑, 1,   UPR↑, 7,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 7,   ATG7↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 13,   CTSK↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 2,   LC3II↑, 9,   LC3s↑, 1,   MitoP↑, 1,   p62↓, 6,   p62↑, 2,   PARK2↑, 1,   SESN2↑, 1,   TumAuto↑, 28,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BRCA2↓, 1,   DNAdam↓, 3,   DNAdam↑, 40,   DNArepair↓, 1,   hTERT/TERT↓, 4,   p16↑, 1,   P53↓, 3,   P53↑, 47,   P53↝, 2,   p‑P53↓, 1,   p‑P53↑, 2,   p73↑, 1,   PARP↓, 2,   PARP↑, 11,   cl‑PARP↓, 1,   cl‑PARP↑, 37,   PARP1↑, 3,   cl‑PARP1↑, 2,   PCNA↓, 21,   POLD1↓, 1,   Telomerase↓, 7,   TOP1↓, 7,   TOP2↓, 4,   TOP2↑, 2,   TP53↓, 1,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CC(CDKs/cyclins)↓, 1,   CDK1↓, 10,   CDK1↑, 2,   CDK2↓, 23,   CDK2↑, 2,   CDK4↓, 24,   CDK4↑, 1,   p‑CDK4↓, 1,   CDK6↓, 6,   CDK6↑, 1,   CDK7↓, 1,   CDK8↓, 1,   CHK1↓, 1,   CHK1↑, 1,   Chk2↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 44,   cycD1/CCND1↑, 2,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 13,   E2Fs↓, 2,   GADD45A↓, 1,   Ki-67↓, 15,   Ki-67↑, 1,   mitA↑, 1,   P21?, 1,   P21↓, 3,   P21↑, 32,   p27/CDKN1B↑, 12,   p‑pRB↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 125,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH↓, 3,   ALDH1A1↓, 2,   BMP7/OP1↓, 1,   BMPs↑, 1,   CD133↓, 3,   CD24↓, 1,   cFos↓, 4,   CSCs?, 1,   CSCs↓, 16,   Diff↑, 2,   FGF↓, 1,   Gli↓, 2,   Gli1↓, 3,   HH↓, 4,   IGF-1?, 1,   IGF-1↓, 8,   IGF-2↓, 1,   IGFBP3↑, 2,   JAG1↓, 1,   Ki-67↓, 15,   Ki-67↑, 1,   Let-7↑, 2,   mTORC1↓, 6,   Nanog↓, 4,   Nestin↓, 2,   NOTCH↓, 9,   NOTCH↑, 1,   NOTCH1↓, 8,   NOTCH1↑, 2,   NOTCH3↓, 2,   PTCH1↓, 1,   SCF↓, 1,   Shh↓, 4,   Smo↓, 2,   STAT1↓, 1,   TumCG↓, 54,   TumCG↑, 4,   TumCP↓, 100,   TumCP↑, 2,   Wnt↓, 24,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AP-1↑, 1,   ASAP2↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 2,   Ca+2↓, 3,   Ca+2↑, 22,   Ca+2↝, 2,   i-Ca+2?, 1,   i-Ca+2↑, 1,   cal2↑, 1,   Cal9↑, 1,   Cdc42↓, 1,   Cofilin↓, 1,   p‑Cofilin↑, 1,   COL1↓, 1,   E-cadherin↓, 5,   E-cadherin↑, 24,   EMT↓, 45,   EMT↝, 1,   EpCAM↓, 2,   F-actin↓, 2,   FAK↓, 8,   FAK↑, 1,   p‑FAK↓, 4,   fascin↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   GLI2↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   KRAS↓, 1,   LAMs↓, 2,   LIMK2↓, 1,   LRP1↑, 1,   MALAT1↓, 1,   MET↓, 1,   MET↑, 1,   MMP1↓, 4,   MMP13↓, 1,   MMP2↓, 56,   MMP2↑, 1,   MMP3↓, 2,   MMP7↓, 4,   MMP9↓, 65,   MMP9↑, 4,   MMPs↓, 24,   N-cadherin↓, 14,   pax↓, 1,   PDGF↓, 5,   Rac1↓, 1,   RECK↑, 1,   Rho↓, 4,   ROCK1↓, 2,   Slug↓, 4,   Smad1↓, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 6,   TET1↑, 2,   TGF-β↓, 10,   TGF-β↑, 1,   TGF-β1↓, 1,   TIMP1↓, 1,   TIMP1↑, 8,   TIMP2↓, 1,   TIMP2↑, 6,   pol-TregCell↓, 1,   TRIB3↑, 2,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 56,   TumCMig↓, 60,   TumMeta↓, 51,   TumMeta↑, 4,   Twist↓, 10,   TXNIP↑, 1,   uPA↓, 13,   Vim?, 1,   Vim↓, 11,   Zeb1↓, 5,   Zeb1↑, 1,   α-SMA↓, 2,   α-SMA↑, 1,   β-catenin/ZEB1↓, 32,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 72,   angioG↑, 2,   CD31/PECAM-1↓, 2,   HIF-1↓, 4,   Hif1a↓, 33,   LOX1↓, 1,   NO↓, 1,   NO↑, 2,   VCAM-1↓, 2,   VEGF↓, 70,   VEGF↑, 1,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 11,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   BBB∅, 1,   CLDN2↓, 1,   EPR↑, 2,   GLUT1↓, 9,   GLUT4↓, 1,   MMP↓, 80,   MMP↑, 2,   MPT↑, 4,   NHE1↓, 1,   TJ↓, 1,   TRPM7↓, 3,   TRPV1↓, 1,   TRPV1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 2,   CD44↓, 7,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 4,   p‑cDC2↓, 1,   COX1↓, 4,   COX2/PTGS2↓, 60,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   CXCc↓, 1,   CXCL12↓, 2,   CXCL16↓, 1,   CXCR4↓, 6,   DR4↑, 3,   Eos↑, 1,   FOXP3↑, 2,   HCAR2↑, 2,   HMGB1↓, 1,   ICAM-1↓, 5,   IFN-γ↓, 3,   IFN-γ↑, 1,   IL1↓, 2,   IL1↑, 1,   IL10↓, 4,   IL10↑, 1,   IL12↑, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 14,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 1,   IL4↓, 2,   IL4↑, 1,   IL6↓, 20,   IL6↑, 1,   IL8↓, 4,   Imm↑, 17,   Imm↝, 4,   INF-γ↝, 1,   Inflam↓, 2,   LRIG1↑, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MCT1↓, 2,   MIP-1β↑, 1,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   MyD88↓, 1,   MyD88↑, 1,   Neut↑, 2,   NF-kB?, 1,   NF-kB↓, 91,   NF-kB↑, 4,   p‑NF-kB↑, 1,   NK cell↑, 6,   NLRP3↓, 3,   NLRP3↑, 3,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 7,   PGE2↓, 15,   PGE2↑, 1,   PSA↓, 10,   RAGE↓, 1,   SOCS-3↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 5,   TLR4↑, 1,   TNF-α↓, 22,   TNF-α↑, 3,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   Treg lymp↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,   pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 1,   ADAM10?, 1,   ADAM10↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,   PSEN2/PS-2↓, 1,   p‑tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 5,   AR-V7?, 1,   CYP19?, 1,   ER(estro)↓, 1,   EstroRS/ERS↑, 1,   PPARα↓, 1,   PPARα↑, 1,   PPARγ↓, 3,   PPARγ↑, 6,   PPARγ↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 35,   BioAv↑, 37,   BioAv⇅, 1,   BioAv↝, 14,   BioEnh↑, 1,   ChemoSen↑, 122,   ChemoSen⇅, 1,   CompStab↑, 1,   CompStab↝, 2,   CYP1A1↓, 4,   CYP1A1↑, 1,   CYP1A2↓, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 8,   Dose↝, 40,   eff↓, 9,   eff↑, 56,   eff⇅, 1,   eff↝, 12,   eff∅, 1,   GSTM1↑, 1,   Half-Life↓, 10,   Half-Life↑, 1,   Half-Life↝, 11,   MDR1↓, 4,   MRP1/ABCC1↝, 1,   P-gp/ABCB1↓, 12,   P-gp/ABCB1⇅, 1,   P450↓, 1,   RadioS↑, 29,   selectivity?, 1,   selectivity↓, 1,   selectivity↑, 59,   selectivity∅, 1,   Synergy↑, 86,   Synergy↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   AFP↓, 2,   ALAT↓, 6,   ALP↓, 1,   AR↓, 5,   ascitic↓, 1,   AST↓, 3,   BP↓, 1,   BRCA1↓, 2,   p‑BRCA1↑, 1,   BUN↓, 1,   CA19-9↓, 1,   CEA↓, 2,   creat↓, 1,   CRP↓, 3,   EGFR↓, 22,   EGFR↑, 1,   EstroRS/ERS↑, 1,   EZH2↓, 3,   FOXM1↓, 2,   HER2/EBBR2↓, 9,   hTERT/TERT↓, 4,   IL6↓, 20,   IL6↑, 1,   KRAS↓, 1,   LDH↑, 2,   LDH↝, 1,   Myc↓, 3,   NOS2↑, 1,   PC↑, 1,   PD-L1↓, 7,   Polyps↓, 1,   PSA↓, 10,   RAGE↓, 1,   RBC↑, 1,   TG/TAG↓, 1,   TP53↓, 1,   TP53↑, 1,   TRIB3↑, 2,   Tumccf↓, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiArt↑, 1,   AntiCan?, 1,   AntiCan↓, 2,   AntiCan↑, 88,   AntiCan∅, 1,   antiD↑, 1,   AntiDiabetic↑, 1,   antiNeop↑, 3,   AntiTum↑, 40,   cachexia↓, 1,   cardioP↑, 12,   CardioT↑, 1,   chemoP↑, 44,   chemoPv↑, 16,   cognitive?, 1,   cognitive↑, 3,   fatigue↓, 1,   fatigue∅, 1,   hepatoP↑, 11,   memory↑, 2,   Mucositis↓, 1,   neuroP↑, 8,   NP/CIPN↓, 2,   Obesity↓, 2,   OS↓, 1,   OS↑, 9,   OS↝, 1,   OS∅, 1,   Pain↓, 2,   PFS↑, 1,   PFS∅, 1,   QoL↑, 4,   QoL∅, 1,   radioP↑, 11,   RenoP↑, 11,   Risk↓, 23,   Risk↑, 2,   toxicity↓, 10,   toxicity↑, 2,   toxicity↝, 10,   toxicity∅, 2,   TumNum↓, 1,   TumVol↓, 12,   TumW↓, 3,   Weight↑, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   GutMicro↑, 9,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr?, 1,   Ingr↝, 7,  
Total Targets: 873

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↑, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 4,   antiOx?, 2,   antiOx↓, 35,   antiOx↑, 504,   ARE↑, 7,   ARE↝, 1,   Bil↑, 2,   Catalase↓, 3,   Catalase↑, 144,   Copper↓, 1,   DPPH↓, 2,   DUOX1↓, 1,   Fenton↓, 4,   GCLC↑, 4,   GCLC↝, 1,   GCLM↑, 3,   GCLM↝, 1,   GPx↓, 2,   GPx↑, 106,   GPx1↑, 4,   GPx3↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GSH↓, 4,   GSH↑, 152,   GSR↓, 2,   GSR↑, 22,   GSS↑, 1,   GSSG↓, 2,   GSTs↓, 4,   GSTs↑, 22,   H2O2↓, 7,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 13,   HDL∅, 1,   HNE↓, 2,   HO-1?, 1,   HO-1↓, 4,   HO-1↑, 131,   HO-1⇅, 1,   HO-1↝, 1,   HO-2↓, 1,   hyperG↓, 3,   hyperG↝, 1,   Iron↓, 4,   Iron↑, 1,   Iron↝, 1,   Keap1↓, 8,   Keap1↑, 1,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 133,   lipid-P↑, 3,   mt-lipid-P↓, 1,   MDA↓, 133,   MDA↑, 4,   MPO↓, 26,   MPO↑, 1,   NADH↓, 1,   NFE2L2↓, 1,   NOX↓, 3,   NOX1↓, 1,   NOX2↓, 2,   NOX4↓, 8,   NQO1↑, 35,   NQO1↝, 2,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 7,   NRF2↑, 225,   NRF2↝, 1,   NRF2∅, 1,   Prx↓, 1,   Prx↑, 2,   RNS↓, 7,   ROS?, 3,   ROS↓, 529,   ROS↑, 9,   ROS⇅, 4,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 2,   SAM-e↑, 1,   selenoP↑, 9,   SOD↓, 4,   SOD↑, 197,   mt-SOD↑, 1,   SOD1↑, 9,   SOD2↓, 1,   SOD2↑, 9,   TAC↑, 23,   TBARS↓, 8,   Thiols↑, 2,   TOS↓, 2,   Trx↓, 1,   Trx↑, 6,   Trx1↑, 2,   TrxR↑, 1,   TrxR1↑, 1,   UCPs↑, 2,   uricA↓, 5,   VitC↑, 8,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   FTH1↑, 1,   IronCh↓, 1,   IronCh↑, 22,   IronCh↝, 1,   Mets↝, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 2,   compII↑, 2,   compIII↑, 2,   compIV↑, 3,   DRP1/DNM1L↓, 1,   EGF↓, 1,   EGF↑, 1,   ETC↑, 3,   HSP60/HSPD1↓, 1,   Insulin↓, 3,   Insulin↑, 3,   MFN2↑, 2,   mitResp↑, 3,   mtDam↓, 10,   mtDam↑, 1,   OCR↑, 4,   OXPHOS↑, 1,   PDH↑, 1,   PGC-1α↓, 3,   PGC-1α↑, 10,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 2,   SIRT3↑, 8,   TFAM↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12-HETE↓, 1,   12LOX↓, 2,   12LOX↑, 1,   5-HETE↓, 1,   5LO↓, 18,   5LO↝, 1,   ACC↓, 1,   ACC↑, 2,   Acetyl-CoA↓, 1,   Acetyl-CoA↑, 3,   ACSL4↓, 2,   adiP↓, 1,   adiP↑, 4,   ALAT?, 1,   ALAT↓, 51,   ALAT∅, 1,   AMPK↓, 2,   AMPK↑, 47,   p‑AMPK↑, 3,   ATP↓, 1,   ATP↑, 28,   ATP↝, 1,   Buty↑, 1,   cAMP↑, 6,   CPT1A↑, 1,   CRM↑, 3,   cytoP450↓, 1,   ECAR↓, 1,   Eic↓, 1,   FABP4↓, 1,   FAO↓, 1,   FAO↑, 3,   FASN↓, 3,   FFA/NEFA↓, 1,   G6PD↑, 1,   glucose↓, 16,   glucose↑, 2,   glucose↝, 4,   GlucoseCon↓, 1,   GlucoseCon↑, 11,   Glycolysis↓, 3,   Glycolysis↑, 1,   GSK‐3β↓, 24,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 4,   H2S↑, 2,   HK2↓, 2,   HMG-CoA↓, 3,   KeyT↝, 1,   lactateProd↓, 1,   LDHA↓, 2,   LDL↓, 39,   lipidLev↓, 6,   lipoGen↓, 1,   LTB4↓, 1,   LTC4↓, 1,   NAD↓, 1,   NAD↑, 3,   NAD↝, 1,   NADH:NAD↑, 1,   NADPH↓, 15,   NADPH↑, 9,   PDKs↓, 1,   PFK↓, 1,   PFK1↓, 1,   PFKP↓, 1,   PGC1A↑, 1,   PGM1?, 1,   PKM2↓, 8,   PLA2↓, 2,   PONs↓, 1,   PONs↑, 1,   SCFAs↑, 1,   SIRT1↓, 1,   SIRT1↑, 48,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,   SREBP1/SREBF1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 74,   Apoptosis↑, 1,   ASK1↓, 1,   BAD↓, 1,   BAX↓, 26,   BAX↑, 1,   Bax:Bcl2↓, 5,   Bcl-2↓, 5,   Bcl-2↑, 21,   Bcl-2↝, 1,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp↓, 4,   Casp1↓, 3,   Casp12↓, 2,   Casp3↓, 47,   Casp3↑, 3,   Casp3∅, 1,   cl‑Casp3↓, 6,   proCasp3↓, 1,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 19,   Casp9↑, 2,   Cyt‑c↓, 7,   Cyt‑c↑, 1,   Cyt‑c∅, 2,   Fas↓, 2,   Ferroptosis↓, 14,   GranB/GZMB↓, 1,   GRP58↓, 1,   GSDMD?, 1,   GSDMD↓, 1,   iNOS↓, 85,   iNOS↑, 3,   necrosis↓, 3,   p38↓, 8,   p38↑, 1,   p‑p38↓, 7,   Pyro↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 13,   Akt↑, 33,   Akt↝, 1,   p‑Akt↓, 6,   p‑Akt↑, 4,   AKT1↓, 1,   Akt2↓, 1,   AMPKα↑, 2,   CREB↓, 1,   CREB↑, 8,   p‑CREB↑, 3,   DYRK1A↓, 2,   EGFR↓, 1,   ERK↓, 14,   ERK↑, 14,   p‑ERK↓, 4,   p‑ERK↑, 3,   HCAR2↑, 1,   HER2/EBBR2↓, 1,   HGF/c-Met↑, 2,   IGF-1R↓, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   IκB?, 1,   JAK↓, 3,   JAK2↓, 3,   JAK2↑, 3,   JNK↓, 20,   JNK↑, 1,   p‑JNK↓, 6,   MAPK?, 1,   MAPK↓, 43,   MAPK↑, 5,   MAPK↝, 2,   p‑MAPK?, 1,   p‑MAPK↓, 2,   MEK↓, 1,   Mst1↓, 1,   mTOR↓, 14,   mTOR↑, 8,   mTOR↝, 1,   p‑mTOR↓, 5,   P70S6K↓, 1,   PDGFR-BB↓, 2,   PDGFR-BB↑, 1,   PDGFRB↓, 1,   PI3K↓, 12,   PI3K↑, 24,   PI3K↝, 1,   PKA↑, 3,   PKCδ↓, 4,   PKCδ↑, 5,   PP2A↑, 4,   PTEN↓, 4,   PTEN↑, 1,   PTP1B↓, 1,   RAS↓, 1,   RIP1↓, 1,   STAT↓, 4,   STAT3?, 1,   STAT3↓, 10,   STAT3↑, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,   STEP↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 14,   ATF2↑, 1,   ATF4↓, 4,   cJun↓, 2,   p‑cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMTs↓, 2,   FOXO↑, 3,   FOXO3↑, 6,   HATs↓, 2,   HDAC?, 1,   HDAC↓, 3,   HDAC↑, 2,   HDAC2↓, 2,   HOTAIR↑, 1,   KLF4↑, 1,   miR-155↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other?, 3,   other↓, 19,   other↑, 32,   other↝, 46,   other∅, 1,   SOX2↑, 1,   SOX9↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 13,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 28,   GRP78/BiP↓, 11,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSF1↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 11,   HSP70/HSPA5↝, 1,   HSP90↓, 1,   HSP90↑, 2,   HSPs↓, 1,   HSPs↑, 2,   HSPs↝, 1,   IRE1↓, 3,   NQO2↑, 1,   PERK↓, 1,   p‑PERK↓, 1,   UPR↓, 1,   UPR↑, 2,   XBP-1↓, 3,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 8,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 3,   LC3II↓, 1,   LC3II↑, 4,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 3,   p62↑, 4,   PARK2↑, 4,   TFEB↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

8-oxo-dG↓, 1,   ATR↑, 1,   DNAdam↓, 28,   p16↓, 2,   P53↓, 5,   PARP↓, 1,   PARP1↓, 2,   cl‑PARP1↓, 1,   PCNA↓, 4,   SIRT6↑, 1,   Telomerase↓, 1,   TOP1↓, 1,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 2,   cellSen↓, 1,   cellSen↝, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↑, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   P21↓, 2,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CEBPA↓, 1,   cFos↑, 1,   CHIP↑, 1,   Choline↑, 2,   Diff↑, 4,   Diff↝, 2,   EP2↓, 1,   FGF↑, 3,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 4,   IGFBP1↑, 1,   Jun↓, 1,   Ki-67↓, 1,   Ki-67↑, 2,   MSCs↑, 1,   mTORC1↓, 1,   Nestin↑, 1,   neuroG↑, 12,   NOTCH1↑, 1,   STAT1↓, 1,   TumCG↑, 1,   TumCP↓, 4,   tyrosinase↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 43,   AntiAg∅, 1,   AP-1↓, 11,   AP-1↑, 1,   ARG1/2↑, 1,   Ca+2?, 2,   Ca+2↓, 17,   Ca+2↑, 6,   Ca+2↝, 4,   cal2↓, 1,   Cartilage↑, 9,   COL1↓, 2,   COL1↑, 2,   COL2A1↑, 2,   COL3A1↓, 1,   E-cadherin↑, 2,   EMT↓, 2,   F-actin↑, 1,   FAK↑, 1,   Fibronectin↑, 1,   Fibrosis↓, 1,   LRP1↑, 3,   MLC2/MYL9↝, 1,   MMP-10↓, 2,   MMP-10↝, 1,   MMP1↓, 1,   MMP13↓, 6,   MMP2↓, 6,   MMP2↑, 2,   MMP3↓, 3,   MMP3↑, 1,   MMP9↓, 19,   MMP9↑, 2,   MMPs↓, 3,   MMPs↑, 3,   MUC1↑, 4,   N-cadherin↑, 1,   Na+↑, 1,   NFAT↓, 1,   PDGF↓, 1,   PDGF↑, 1,   p‑Rac1↓, 1,   Rho↓, 3,   ROCK1↓, 4,   serineP↓, 1,   SLIT2↑, 1,   SMAD3↓, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 10,   TGF-β↑, 10,   TGF-β1↓, 4,   TGF-β1↑, 3,   TIMP1↓, 5,   TIMP1↑, 3,   TIMP2↑, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 6,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 2,   Vim↑, 1,   α-SMA↓, 4,   α-SMA↑, 1,   α-SMA↝, 1,   β-catenin/ZEB1↑, 2,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   angioG↑, 8,   angioG↝, 1,   CD31/PECAM-1↓, 1,   CD31/PECAM-1↑, 1,   E-sel↓, 4,   ECM/TCF↑, 1,   eNOS↓, 1,   eNOS↑, 4,   p‑eNOS↑, 1,   HIF-1↓, 1,   Hif1a↓, 8,   Hif1a↑, 3,   Hif1a↝, 1,   Hif1a∅, 1,   HIF2a↑, 1,   LOX1↓, 1,   NO?, 1,   NO↓, 66,   NO↑, 7,   TXA2↓, 3,   VCAM-1↓, 18,   VEGF↓, 13,   VEGF↑, 11,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 2,   BBB↓, 8,   BBB↑, 74,   BBB↝, 6,   BBB∅, 3,   CLDN1↓, 1,   CLDN1↑, 3,   CLDN3↑, 1,   CLDN4↑, 1,   EPR↑, 2,   GastroP↑, 14,   GLUT1↑, 2,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 6,   H+/K+-ATPase↓, 1,   IBI↑, 11,   memfluid↑, 2,   MMP↓, 1,   MMP↑, 29,   MMP∅, 1,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   MUC5AC↓, 2,   Na+↑, 1,   OATPs↓, 1,   OCLN↓, 2,   OCLN↑, 6,   OCLN↝, 1,   TJ↑, 6,   TRPA1↑, 2,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV1↑, 5,   TRPV3↑, 2,   VGCC↓, 1,   VGSC↓, 1,   ZO-1↓, 1,   ZO-1↑, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CB2 / CNR2↑, 5,   CCL11↓, 1,   CD19↑, 1,   CD25+↑, 1,   CD4+↑, 5,   CD40↓, 1,   CD8+↑, 1,   cGAS–STING↓, 2,   COX1↓, 13,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 140,   COX2/PTGS2↑, 2,   CXCc↓, 1,   CXCL1↓, 1,   CXCL15↓, 1,   CXCR2↓, 1,   CXCR3↓, 1,   CXCR4↓, 1,   Eos↓, 5,   FOXP3↑, 1,   GM-CSF↓, 1,   HCAR2↑, 1,   HMGB1↓, 9,   ICAM-1↓, 16,   IFN-γ↓, 19,   IFN-γ↑, 4,   IFN-γ∅, 1,   IgE↓, 4,   IgG1↓, 1,   IL1?, 1,   IL1↓, 10,   IL1↑, 1,   IL10?, 1,   IL10↓, 16,   IL10↑, 28,   IL12↓, 7,   IL13↓, 6,   IL17↓, 15,   IL17↑, 1,   IL18↓, 4,   IL1RL1/ST2↓, 1,   IL1α↓, 1,   IL1β↓, 158,   IL1β↑, 1,   IL2↓, 14,   IL2↑, 1,   IL22↓, 1,   IL23↓, 3,   IL33↓, 3,   IL4↓, 19,   IL4↑, 7,   IL5↓, 8,   IL5↑, 1,   IL6?, 2,   IL6↓, 187,   IL6↑, 4,   IL8?, 1,   IL8↓, 31,   IL8↑, 1,   ILC2↓, 1,   Imm↓, 1,   Imm↑, 47,   Imm↝, 4,   INF-γ↓, 3,   Inflam↓, 1076,   Inflam↑, 1,   IP-10/CXCL-10↓, 2,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 21,   MCP1/CCL2↑, 2,   MCP1/CCL2↝, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 3,   MyD88↓, 8,   NeuroI↓, 4,   Neut↓, 1,   Neut↑, 2,   NF-kB↓, 241,   NF-kB↑, 2,   p‑NF-kB↓, 3,   NK cell↑, 4,   NLRP3↓, 66,   NLRP3↑, 3,   p65↓, 6,   PAF↓, 2,   PAF↑, 1,   PGE1↓, 1,   PGE2↓, 49,   PGE2↑, 2,   PSA↓, 1,   PSA∅, 1,   RAGE↓, 5,   RANTES↓, 4,   Th1 response↓, 1,   Th17↓, 1,   Th2↓, 2,   TLR1↓, 3,   TLR2↓, 7,   TLR4↓, 35,   TLR4↑, 1,   TLR4∅, 1,   TNF-α↓, 260,   TNF-α↑, 3,   TRAF1↓, 1,   Treg lymp↑, 1,   Treg lymp↝, 1,   TRIF↓, 3,   VitD↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   GGT/CD224↓, 1,   TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 2,   5HT↓, 1,   5HT↑, 16,   Ach↑, 25,   AChE↓, 95,   AChE↑, 1,   AChE∅, 2,   ADAM10↑, 6,   ADAM10↝, 1,   BChE↓, 24,   BChE∅, 1,   BDNF↓, 3,   BDNF↑, 68,   BDNF∅, 2,   proBDNF↑, 1,   BrainVol↑, 2,   ChAT↑, 12,   ChE↓, 1,   GABA↓, 3,   GABA↑, 7,   GABA↝, 1,   MAOA↓, 11,   MAOB↓, 4,   monoA↑, 1,   NGF↑, 9,   PSD95↑, 6,   SNAP25↑, 2,   SYP↑, 1,   TPH1↓, 1,   TrkB↑, 8,  

Protein Aggregation(tgid=19) ⓘ

AEP↓, 1,   AGEs↓, 11,   APOE4↓, 1,   APP↓, 15,   cl‑APP↑, 1,   Aβ↓, 159,   Aβ↑, 2,   Aβ∅, 1,   Aβ42↓, 9,   BACE/β-secretase↓, 35,   BACE/β-secretase↑, 1,   IDE↑, 1,   NEP↑, 1,   PSEN1/PS1↑, 1,   tau↓, 34,   p‑tau↓, 48,   XO↓, 2,   XO↝, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AhR↑, 2,   AR↓, 1,   BNP↓, 1,   cortisol↓, 1,   cortisol↑, 1,   CYP19↓, 1,   DHT↑, 1,   ER(estro)↓, 1,   ER(estro)↑, 2,   ERβ/ESR2↑, 1,   Estro↓, 1,   GLP-1R↑, 1,   GR↑, 1,   NR1H4↑, 1,   PPARα↑, 10,   PPARα↝, 1,   PPARγ↓, 4,   PPARγ↑, 24,   RAAS↓, 1,   SHBG↓, 1,   testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 73,   BioAv↑, 115,   BioAv⇅, 3,   BioAv↝, 65,   BioEnh↑, 11,   ChemoSen↑, 2,   CompStab↓, 2,   CompStab↑, 7,   CompStab↝, 3,   CYP2C19↓, 1,   CYP2C9↓, 1,   CYP2D6↓, 1,   CYP2E1↓, 1,   CYP3A4↓, 1,   DDS↑, 1,   Dose?, 10,   Dose↓, 3,   Dose↑, 8,   Dose↝, 142,   eff?, 1,   eff↓, 9,   eff↑, 84,   eff↝, 11,   GSTA1↑, 7,   Half-Life?, 1,   Half-Life↓, 17,   Half-Life↑, 8,   Half-Life↝, 29,   P-gp/ABCB1↓, 3,   P450↓, 3,   RadioS↑, 1,   selectivity↑, 5,   Synergy↑, 48,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 51,   ALAT∅, 1,   ALB↑, 2,   ALB↝, 1,   ALP↓, 9,   AR↓, 1,   AST↓, 53,   AST∅, 1,   BG↓, 3,   Bil↑, 2,   BloodF↑, 13,   BMD↑, 8,   BP↓, 29,   BP↝, 1,   BP∅, 1,   BUN?, 1,   BUN↓, 6,   Calcium↑, 1,   Calcium↝, 2,   CEA↓, 1,   CK/CK-MB↓, 1,   colonLen↑, 2,   creat↓, 16,   CRP↓, 21,   EGFR↓, 1,   Ferritin↑, 1,   HbA1c↓, 1,   Hcy/homoC↓, 3,   Hcy/homoC↝, 1,   HemoG↑, 1,   HER2/EBBR2↓, 1,   HOMA↓, 1,   hs-CRP↓, 5,   IL6?, 2,   IL6↓, 187,   IL6↑, 4,   IRes↓, 1,   IRes↑, 1,   IRes↝, 1,   KeyT↝, 1,   LDH↓, 18,   Mag↑, 1,   NLR↓, 1,   NOS2↓, 5,   PSA↓, 1,   PSA∅, 1,   PV↓, 3,   RAGE↓, 5,   SpO2↑, 1,   TC↓, 4,   TG/TAG↓, 6,   TMAO↓, 1,   TP53↑, 1,   UFR?, 1,   UFR↑, 2,   UR↓, 1,   Urea↓, 5,   VitD↑, 2,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 2,   AirwayM↓, 4,   Analgesic↑, 6,   AntiAge↑, 31,   antiAll?, 1,   antiAll↑, 44,   AntiArt↑, 16,   AntiCan↓, 2,   AntiCan↑, 80,   antiCG↑, 2,   antiD↑, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 84,   antiM↑, 1,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 3,   antiPy↑, 1,   AntiTum↓, 2,   AntiTum↑, 25,   ANXi↓, 1,   BOLD↑, 1,   Bone Healing↑, 1,   cachexia↓, 1,   cardioP?, 1,   cardioP↓, 3,   cardioP↑, 169,   cardioP⇅, 1,   cardioP∅, 1,   chemoP↑, 28,   chemoPv↑, 19,   ChemoSideEff↓, 1,   cognitive↓, 2,   cognitive↑, 215,   cognitive↝, 1,   cognitive∅, 1,   cough?, 1,   diuretic↑, 6,   fatigue↓, 2,   Hear↑, 1,   hepatoP↓, 5,   hepatoP↑, 150,   IPSS↝, 1,   Learn?, 1,   Learn↑, 16,   memory?, 1,   memory↑, 179,   Mood↑, 12,   motorD↑, 23,   Mucositis↓, 2,   neuroP?, 3,   neuroP↓, 3,   neuroP↑, 386,   neuroP↝, 1,   NP/CIPN↓, 3,   Obesity↓, 37,   OS↑, 14,   Pain↓, 27,   PDE4↓, 1,   QoL↓, 1,   QoL↑, 8,   radioP↑, 15,   RenoP↑, 49,   Risk↓, 19,   Sleep↑, 7,   SoreThr?, 1,   Strength↓, 1,   Strength↑, 8,   Stress↓, 3,   Stroke↓, 31,   Tinn↓, 1,   toxicity?, 1,   toxicity↓, 84,   toxicity↑, 11,   toxicity⇅, 1,   toxicity↝, 21,   toxicity∅, 10,   Weight↓, 5,   Weight↑, 2,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 21,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   AntiBio↑, 53,   AntiFungal↓, 2,   AntiFungal↑, 23,   AntiP↓, 1,   AntiP↑, 7,   AntiViral↑, 37,   Bacteria↓, 84,   Bacteria↑, 1,   Diar↓, 6,   Dysb↓, 1,   GutMicro↑, 90,   GutMicro↝, 2,   Inf↓, 3,   Sepsis↓, 19,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   CA↑, 1,   Catechins↑, 1,   FA↑, 1,   Fibre↑, 1,   Flav↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↑, 5,   Ingr↝, 35,   LT↑, 1,   Myr↑, 1,   Phen↑, 1,   Poly↑, 1,   QC↑, 2,  
Total Targets: 998

Scientific Paper Hit Count for: Inflam, inflammation
39 Hydrogen Gas
37 Curcumin
32 Magnetic Fields
29 Quercetin
28 Thymoquinone
21 Resveratrol
21 Silymarin (Milk Thistle) silibinin
18 Selenium NanoParticles
17 Alpha-Lipoic-Acid
16 Rosmarinic acid
16 Lycopene
15 Ferulic acid
14 Berberine
14 Kaempferol
13 Capsaicin
13 Fisetin
13 Sulforaphane (mainly Broccoli)
13 Licochalcone A
13 Luteolin
13 Urolithin
12 Silver-NanoParticles
12 Carvacrol
12 Honokiol
11 Emodin
10 Apigenin (mainly Parsley)
10 Ashwagandha(Withaferin A)
10 Beta-Caryophyllene
10 Propolis -bee glue
10 Chlorogenic acid
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Eugenol
10 Isoliquiritigenin
10 Pterostilbene
9 Baicalein
9 Boron
9 Chrysin
9 Cinnamon
9 Ginger/6-Shogaol/Gingerol
9 Morin
8 Rutin
8 Isovitexin
8 Magnolol
8 Matrine
7 Selenite (Sodium)
7 Radiotherapy/Radiation
7 α-Bisabolol / Chamomile oil
7 D-limonene
7 Moringa oleifera
7 Piperine
7 Vitamin C (Ascorbic Acid)
7 Shikonin
6 Artemisinin
6 Betulinic acid
6 Vitamin B3,Niacin
6 Crocetin
6 Gallic acid
6 Hyperoside
6 Vitexin
6 L-Theanine
5 1,8-Cineole
5 Allicin (mainly Garlic)
5 Aspirin
5 Astaxanthin
5 Folic Acid, Vit B9
5 Cisplatin
5 Boswellia (frankincense)
5 doxorubicin
5 Caffeic acid
5 Thymol-Thymus vulgaris
5 Centella asiatica / Gotu kola → asiaticoside
5 chitosan
5 Hydroxycinnamic-acid
5 Flaxseed/Linseed
5 Fucoidan
5 Shilajit/Fulvic Acid
5 HydroxyTyrosol
5 isoorientin
5 Mung Bean Sprouts
5 Licorice
5 Magnetic Field Rotating
5 Mushroom Lion’s Mane, Hericium erinaceus
5 Phycocyanin
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Bacopa monnieri
4 Butyrate
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Cichoric acid / Chicoric acid
4 Coenzyme Q10
4 Carvone
4 Chemotherapy
4 Ellagic acid
4 Ginkgo biloba-EGb 761
4 Formononetin
4 Ginkgetin
4 Isobavachalcone
4 Isorhamnetin
4 isoquercitrin
4 Lactoferrin/Talactoferrin
4 Lemongrass Extract/Citral
4 Methylene blue
4 Methylsulfonylmethane
4 nicotinamide adenine dinucleotide
4 Piperlongumine
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin K2
3 Anethole/trans-Anethole
3 Biochanin A
3 Vitamin B12
3 Black Rice, Oryza sativa
3 Lecithin
3 Carnosine
3 Camu camu
3 Chocolate
3 Chyawanprash
3 methotrexate
3 Cucurbitacin
3 Diclofenac
3 Date Fruit Extract
3 diet Fermented Foods
3 Exercise
3 SDG/lignans
3 Gamma-aminobutyric acid
3 Garcinol
3 Ginkgo biloba
3 Genistein (soy isoflavone)
3 Geraniol
3 Marjoram (Origanum majorana)
3 α-Santalol/Sandalwood oil
3 Vitamin B1/Thiamine
3 Vitamin D3
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Benzyl isothiocyanate
2 brusatol
2 borneol
2 Cat’s Claw
2 Chlorophyllin
2 Selenium
2 Spermidine
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 Docosahexaenoic Acid
2 Indole-3-carbinol
2 Dipyridamole
2 eicosapentaenoic acid
2 Eurycomanone
2 flavonoids
2 Ginkgolide B
2 Ginseng
2 hydrogen sulfide
2 HydroxyCitric Acid
2 Hibiscus sabdariffa
2 Oleuropein
2 Isothiocyanates
2 Ivermectin
2 Juglone
2 Potassium
2 Linalool
2 Lutein
2 Methyl salicylate / Sweet Birch oil
2 Metformin
2 Magnesium
2 Mangiferin
2 Lemon Balm/Melissa officinalis
2 Nimbolide
2 Oleocanthal
2 Patchouli Oil (Pogostemon cablin)
2 Purple Corn / Purple Maize
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Terpinen-4-ol / Tea Tree Oil
2 Ursolic acid
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Astragalus
1 Acetyl-l-carnitine
1 Aloe anthraquinones
1 beta-glucans
1 Baicalin
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 buckwheat sprouts
1 Carnosic acid
1 Castalagin
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celecoxib
1 Celastrol
1 Prebiotic
1 Choline
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Vitamin E
1 Rivastigmine
1 Chlorella (Chlorella vulgaris)
1 Cynaropicrin
1 Dihydrocaffeic Acid
1 diet Short Term Fasting
1 Diindolylmethane
1 Disulfiram
1 immunotherapy
1 Echinacea
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 γ-linolenic acid (Borage Oil)
1 Grapeseed extract
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Orlistat
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Inositol
1 iodine
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 isoflavones
1 Zeaxanthin
1 MBE, Maqui berry
1 MCT oil
1 Moringin
1 Melatonin
1 5-fluorouracil
1 Mucuna pruriens/Velvet Bean
1 Mushroom Chaga, Inonotus obliquus
1 Naringin
1 Nasturtium, Indian Cress
1 Neem
1 Oregano
1 Peppermint
1 Phenylbutyrate
1 Phenolic Acids
1 Psoralidin
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 Radio Frequency
1 Aromatherapy
1 Sulfasalazine
1 Gold NanoParticles
1 Sesamin
1 Sesame seeds and Oil
1 Silicic Acid
1 Salvia miltiorrhiza
1 Spirulina(Arthrospira/Limnospira)
1 cetuximab
1 Terminalia bellirica
1 Terpenoids
1 Aflavin-3,3′-digallate
1 Thyme
1 Turmerones
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 probiotics
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:953  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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