eff Cancer Research Results

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Power to enhance an anti cancer effect
Scientific Papers found: Click to Expand⟱
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
2287- AgNPs,    Silver nanoparticles induce endothelial cytotoxicity through ROS-mediated mitochondria-lysosome damage and autophagy perturbation: The protective role of N-acetylcysteine
- in-vitro, Nor, HUVECs
*TumCP↓, *ROS↑, *eff↓, *MDA↑, *GSH↓, *MMP↓, *ATP↓, *LC3II↑, *p62↑, *Bcl-2↓, *BAX↑, *Casp3↑,
1916- AL,    Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods
- Review, Nor, NA
*BioAv↝, *eff↓, *BioAv↝, *BioAv↝, *eff↑, *Half-Life∅, *eff↑, *eff↑, *Dose∅, *eff↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
5574- B-Gluc,    Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome
- Review, Obesity, NA
*BioAv↑, *toxicity↓, *Imm↑, *eff↑, *Risk↓, *Weight↓, *eff↝, *BP↓, *GutMicro↑, *eff↓,
5650- BNL,    Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model
- in-vivo, Nor, NA
*P-gp/ABCB1↓, *NF-kB↑, *eff↓, *Dose↝,
744- Bor,    Borax affects cellular viability by inducing ER stress in hepatocellular carcinoma cells by targeting SLC12A5
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
TumCCA↑, SLC12A5↓, ATF6↑, CHOP/DDIT3↑, GRP78/BiP↑, Casp3↑, ER Stress↝, *toxicity↓, *eff↓,
8976- BRice,    Influence of cooking on anthocyanins in black rice (Oryza sativa L. japonica var. SBR)
- Study, Nor, NA
*eff↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
6123- CHr,    Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms
- Review, Nor, NA
*eff↓, *BioAv↓, *eff↑, *BioAv↓, OATPs↓, MRP↓,
9271- CRAN,    Cranberries for preventing urinary tract infections
- Review, UTI, NA
*Ingr↝, *Risk↓, *eff↓,
6408- CUR,    Protective Effects of a Natural Product, Curcumin, against Amyloid β Induced Mitochondrial and Synaptic Toxicities in Alzheimer'S Disease
- in-vitro, AD, SH-SY5Y
*mtDam↓, *eff↓, *eff↑, *FIS1↓, *lipid-P↓, *ATP↑,
2265- dietMet,    Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase
- in-vivo, Nor, NA
*SCD1↓, *Weight↓, *Insulin↓, *IGF-1↓, *adiP↑, *eff↓,
660- EGCG,  FA,    Epigallocatechin-3-gallate Delivered in Nanoparticles Increases Cytotoxicity in Three Breast Carcinoma Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
Apoptosis↑, *toxicity↓, *eff↓,
6956- FA,  VitB12,    A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients
- Trial, AD, NA
*Dose↝, *Hcy/homoC↓, *cognitive↑, *eff↓,
6983- Form,    Formononetin enhances angiogenesis in diabetic wounds by inhibiting ferroptosis through suppression of mtROS-mediated xCT/GPX4 upregulation
- vitro+vivo, Nor, HUVECs - vitro+vivo, Diabetic, NA
*BloodF↑, *Ferroptosis↓, *eff↓, *mtDam↓, *xCT/SLC7A11↑, *GPx4↑, *Wound Healing↑, *CD31/PECAM-1↑, *mt-ROS↓,
823- GAR,    Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10 - in-vitro, CRC, HCT116
Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,
7141- GI,    Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Study, Nor, BV2
*eff↑, *CompStab↓, *NRF2↑, *Inflam↓, *eff↑, *antiOx↑, *neuroP↑, *COX2/PTGS2↓, *NF-kB↓, *eff↓, *BioAv↝, *CompStab↑,
8559- Matr,    Matrine induces toxicity in mouse liver cells through an ROS-dependent mechanism
- vitro+vivo, Nor, NA
*Dose↝, *toxicity↑, *Casp3↑, *Casp9↑, *ROS↑, *MMP↓, *ATP↓, *eff↓,
2236- MF,    Changes in Ca2+ release in human red blood cells under pulsed magnetic field
- in-vitro, Nor, NA
*Ca+2↓, *eff↓, *ROS↓,
2238- MF,    Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects
- Review, Var, NA
*BMD↑, *VGCC↑, *Ca+2↑, *NO↑, *eff↓,
3479- MF,    Evaluation of Pulsed Electromagnetic Field Effects: A Systematic Review and Meta-Analysis on Highlights of Two Decades of Research In Vitro Studies
- Review, Var, NA
*eff↓, eff↝, *Hif1a↑, *VEGF↑, *TIMP1↑, *E2Fs↑, *MMP2↑, *MMP9↑, Apoptosis↑,
520- MF,    Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3β signaling pathway
- in-vitro, Nor, NA
*MPT↑, *Cyt‑c↑, *ROS↑, *p‑GSK‐3β↑, *eff↓, *MMP∅, *BAX↓, *Bcl-2∅,
4355- MF,    Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism
- in-vitro, Nor, C2C12
*mt-OCR↑, *mt-ROS↑, *ECAR↑, *Dose↝, *Ca+2↑, *ATP↑, *other↑, *eff↓, *eff↝,
2262- MFrot,  MF,    Effects of 0.4 T Rotating Magnetic Field Exposure on Density, Strength, Calcium and Metabolism of Rat Thigh Bones
- in-vivo, ostP, NA
*BMD↑, *eff↓, *ALP↑, *other↑,
3846- MSM,    Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
- Human, Nor, NA
*Dose↝, *BBB↑, *eff↓,
2964- PL,    Preformulation Studies on Piperlongumine
- Analysis, Nor, NA
*BioAv↓, *BioAv↑, *other↝, *eff↓,
8606- PumpSO,  Tamsu,    Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial
- Trial, BPH, NA
*Dose?, *toxicity↓, *eff↓, *IPSS↝, *other↝, *UFR?, *5-AR↓, *Inflam↓,
5030- QC,    Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
- in-vivo, Nor, NA
*MitoP↑, *NRF2↑, Synergy↑, *eff↓, *GutMicro↑,
1495- SFN,  doxoR,    Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation
- in-vivo, Nor, NA
*CardioT↓, *NRF2↑, *eff↓, *ROS↓,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG1/2↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,
2217- SK,    Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway
- in-vivo, Nor, NA - in-vitro, Nor, HK-2
*ER Stress↓, *SIRT1↑, *NRF2↑, *HO-1↑, *eff↓, *RenoP↑, *GRP78/BiP↓, *CHOP/DDIT3↓, *Casp12↓, *BAX↓, *cl‑Casp3↓,
2215- SK,  doxoR,    Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- in-vivo, Nor, NA
*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,
4861- Uro,    Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *toxicity↓, *BBB↑, *p‑tau↓, *eff↓, *IL1α↓, *MCP1/CCL2↓, *MIP‑1α/CCL3↓, *TNF-α↓, *IL2↓, *SIRT1↓, *DNAdam↓, *Dose↝, *Strength↑, *motorD↑, *CTSZ↓,
4326- VitB5,    Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
- in-vivo, HD, NA
*Risk↓, *neuroP↑, *other?, *Ach↑, *other↝, *eff↓, *other↝,

Showing Research Papers: 1 to 37 of 37

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 37

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 1,   DR5↑, 1,   survivin↓, 1,   XIAP↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ac‑H3↓, 1,   ac‑H4↓, 1,   HDAC↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↝, 1,   GRP78/BiP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Barriers & Transport(tgid=15) ⓘ

OATPs↓, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 2,   eff↝, 2,   MRP↓, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   GPx↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 4,   HDL↑, 2,   HO-1↑, 2,   lipid-P↓, 1,   MDA↓, 1,   MDA↑, 1,   NRF2↑, 8,   ROS↓, 5,   ROS↑, 3,   ROS⇅, 1,   mt-ROS↓, 1,   mt-ROS↑, 1,   SOD↑, 2,   VitC↑, 1,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

FIS1↓, 1,   Insulin↓, 1,   mtDam↓, 2,   mt-OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   adiP↑, 1,   AMPK↑, 1,   ATP↓, 2,   ATP↑, 2,   ECAR↑, 1,   glucose↑, 1,   p‑GSK‐3β↑, 1,   LDL↓, 2,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 2,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-2∅, 1,   Casp12↓, 1,   Casp3↑, 2,   cl‑Casp3↓, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   e-Akt↑, 1,   AMPKα↑, 1,   ERK↑, 1,   e-ERK↑, 1,   HCAR2↑, 1,   MAPK↑, 1,   Mst1↓, 1,   PI3K↑, 1,   PKCδ↑, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 3,   other↝, 4,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

CTSZ↓, 1,   LC3II↑, 1,   MitoP↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   ARG1/2↑, 1,   Ca+2↓, 1,   Ca+2↑, 2,   MMP2↑, 1,   MMP9↓, 1,   MMP9↑, 1,   TGF-β↑, 1,   TIMP1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↑, 1,   eNOS↑, 1,   Hif1a↑, 1,   NO↓, 1,   NO↑, 1,   VCAM-1↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CLDN1↑, 1,   GLUT1↑, 1,   GLUT4↑, 1,   MMP↓, 2,   MMP∅, 1,   MPT↑, 1,   VGCC↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   HCAR2↑, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 7,   MCP1/CCL2↓, 1,   MIP‑1α/CCL3↓, 1,   NF-kB↓, 3,   NF-kB↑, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5-AR↓, 1,   Ach↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 4,   CompStab↓, 1,   CompStab↑, 1,   Dose?, 1,   Dose↝, 6,   Dose∅, 1,   eff↓, 39,   eff↑, 9,   eff↝, 3,   Half-Life↑, 1,   Half-Life∅, 1,   P-gp/ABCB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↑, 1,   BloodF↑, 1,   BMD↑, 2,   BP↓, 2,   CRP↓, 1,   Hcy/homoC↓, 1,   IL6↓, 1,   UFR?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   BOLD↑, 1,   cardioP↑, 3,   CardioT↓, 1,   cognitive↑, 4,   IPSS↝, 1,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   RenoP↑, 1,   Risk↓, 6,   Strength↑, 1,   toxicity↓, 5,   toxicity↑, 1,   Weight↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 158

Scientific Paper Hit Count for: eff, efficacy
6 Magnetic Fields
3 Shikonin
2 Folic Acid, Vit B9
2 doxorubicin
1 Anthocyanins
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 beta-glucans
1 borneol
1 Boron
1 Black Rice, Oryza sativa
1 Butyrate
1 Chocolate
1 Chrysin
1 Cranberry
1 Curcumin
1 diet Methionine-Restricted Diet
1 EGCG (Epigallocatechin Gallate)
1 Vitamin B12
1 Formononetin
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Matrine
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Piperlongumine
1 Pumpkin Seed Oil / Cucurbita pepo
1 Tamsulosin
1 Quercetin
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Urolithin
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:961  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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