IL1β Cancer Research Results

IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *Synergy↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, Synergy↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑, *antiAll↑,
6468- 1,8-Cin,    Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *antiAll↑,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
9258- Acai, EO,    Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice
- in-vivo, CRC, NA
Risk↓, *MPO↓, *TNF-α↓, *IL1β↓, *IL6↓, *PCNA↓, *Bcl-2↓, *cl‑Casp3↓, *COX2/PTGS2?,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2661- AL,    Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *ROS↓, *NLRP3↓, *TLR4↓, *PKCδ↑, neuroP↑,
3449- ALA,    Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells
- in-vitro, AD, SK-N-BE
*antiOx↑, *NRF2↑, *NF-kB↓, *IL1β↓, *IL6↓, neuroP↑,
3456- ALA,    Renal-Protective Roles of Lipoic Acid in Kidney Disease
- Review, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Inflam↓, *Sepsis↓, *IronCh↑, *BUN↓, *creat↓, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *chemoP↑, *eff↑, *NF-kB↓,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
7396- Amla,    Enhancing cognitive memory function using Phyllanthus emblica polysaccharides via modulating autophagy and reshaping the gut microbiota
- in-vivo, AD, NA
*Inflam↓, *antiOx↓, *GutMicro↑, *cognitive↑, *TNF-α↓, *IL6↓, *IL1β↓, *MDA↓, *IL4↑, *IL10↑, *TAC↑, *ATG5↑, *Beclin-1/ATG6↑, *LC3B↑, *LRP1↑, *BACE/β-secretase↓, *APP↓, *Aβ↓, *tau↓,
6400- ANE,  FEO,    A comprehensive review of the neurological effects of anethole
- Review, AD, NA
*neuroP↑, *antiOx↓, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *motorD↑, *MAOA↓, *memory↑, *AChE↓, *PI3K↑, *Akt↑, *mTOR↑,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
3665- ART/DHA,    Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
- Review, AD, NA
*Inflam↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *MyD88↓, *NF-kB↓, *TLR4↓, *memory↑,
3685- Ash,    Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *NOX↓, *cognitive↑, *Inflam↓, *NF-kB↓,
3166- Ash,    Exploring the Multifaceted Therapeutic Potential of Withaferin A and Its Derivatives
- Review, Var, NA
*p‑PPARγ↓, *cardioP↑, *AMPK↑, *BioAv↝, *Half-Life↝, *Half-Life↝, *Dose↑, *chemoPv↑, IL6↓, STAT3↓, ROS↓, OXPHOS↓, PCNA↓, LDH↓, AMPK↑, TumCCA↑, NOTCH3↓, Akt↓, Bcl-2↓, Casp3↑, Apoptosis↑, Synergy↑, NF-kB↓, CSCs↓, HSP90↓, PI3K↓, FOXO3↑, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, FASN↓, ACLY↓, ROS↑, NRF2↑, HO-1↑, NQO1↑, JNK↑, mTOR↓, neuroP↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL18↓, RadioS↑, ChemoSen↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
1522- Ba,    Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
- in-vitro, Nor, RAW264.7
*p‑STAT1↓, *p‑STAT3↓, *p‑JAK1↓, *p‑JAK2↓, *iNOS↓, *NO↓, *IL1β↓, *IL6↓, *TNF-α↓, *ROS↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, AD, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6495- BCP,    Beta-caryophyllene is a dietary cannabinoid
- Study, Nor, NA
*CB2 / CNR2↑, *other↝, *Inflam↓, *TNF-α↓, *IL1β↓, *ERK↓, *JNK↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp/ABCB1↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3515- Bor,    EVIDENCE THAT BORON DOWN-REGULATES INFLAMMATION THROUGH THE NF-(KAPPA)B PATHWAY
- in-vitro, Nor, NA
*TNF-α↓, *IL1β↓, *MIP‑1α/CCL3↓, *iNOS↓, *NF-kB↓,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6553- BSB,    Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms
- Review, Nor, NA
*ROS↓, *Inflam↓, *Inf↓, *neuroP↑, *RNS↓, *MDA↓, *GSH↑, *MPO↓, *SOD↑, *Catalase↑, *Bcl-2↑, *BAX↓, *P53↓, *APAF1↓, *Casp3↓, *Casp9↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *ERK↓, *JNK↓, *NF-kB↓, *p38↓, *cognitive↑, *BChE↓,
6557- BSB,    Alpha-bisabolol protects against neonatal asthma by suppressing airway inflammatory signaling
- in-vivo, Nor, NA
*ROS↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL17↓, *CXCR4↓, *COX2/PTGS2↓, *TLR4↓, *NO↓, *MDA↓, *XO↓, *antiAll↑,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *LTA/TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
4264- CA,    Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2HO-1 Pathway
- in-vivo, AD, NA
*NRF2↑, *HO-1↑, *Trx1↑, *BDNF↑, *5HT↑, *ROS↓, *TNF-α↓, *IL1β↓, *iNOS↓,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *Stroke↓, *Risk↓,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *Stroke↓, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,

Showing Research Papers: 1 to 50 of 247
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 247

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 3,   Catalase↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 5,   GSH↑, 2,   GSR↓, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 3,   Iron↑, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 2,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 3,   ROS↓, 9,   ROS↑, 25,   ROS⇅, 1,   SOD?, 1,   SOD↓, 3,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,   MFN2↑, 1,   mtDam↑, 1,   OXPHOS↓, 1,   PDH↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↓, 2,   AMPK↑, 4,   ATP↓, 2,   ATP↑, 1,   CAIX/CA9↓, 1,   FASN↓, 1,   FDG↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HK2↓, 2,   lactateProd↓, 3,   LDHA↓, 1,   NADPH↓, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   TCA↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 22,   ASC↓, 1,   ASC↑, 1,   Bak↓, 1,   BAX↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 1,   Bcl-2↓, 14,   Bcl-2↑, 1,   Bcl-xL↓, 2,   BID↑, 1,   BNIP3↑, 1,   BNIP3↝, 1,   Casp↑, 2,   Casp↝, 1,   Casp1↓, 2,   Casp3↑, 16,   cl‑Casp3↑, 4,   cl‑Casp3⇅, 1,   Casp7↑, 2,   Casp8↑, 5,   cl‑Casp8↑, 1,   Casp9↑, 6,   cl‑Casp9↑, 2,   Cyt‑c↑, 7,   mt-Cyt‑c↓, 1,   Diablo↑, 1,   DR5↑, 4,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 1,   GranB/GZMB↝, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   ICAD↓, 1,   iNOS↓, 1,   Mcl-1↓, 1,   MDM2↓, 2,   p‑MDM2↓, 1,   p38↓, 1,   p38↑, 2,   p‑p38↑, 1,   Perforin↝, 1,   survivin↓, 7,   TumCD↓, 1,   TumCD↑, 1,   XIAP↓, 4,   XIAP↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 18,   Akt↑, 1,   p‑Akt↓, 6,   cSrc↓, 1,   EGFR↓, 2,   EGFR↑, 2,   ERK↓, 5,   p‑ERK↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 2,   HGF/c-Met↓, 1,   HRAS↓, 1,   IKKα↓, 1,   JAK↓, 1,   JAK2↓, 4,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 2,   MAPK↝, 1,   MARK4↓, 1,   mTOR↓, 14,   mTOR↝, 1,   P70S6K↓, 2,   PI3K↓, 15,   p‑PI3K↓, 2,   PKCδ↓, 1,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   Sp1/3/4↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 15,   p‑STAT3↓, 1,   STAT4↓, 1,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 3,   cMyc↓, 5,   DNMT1↓, 2,   EZH2↓, 2,   FOXM1↓, 2,   FOXO1↓, 1,   FOXO1↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   FOXO4↓, 1,   H3↓, 1,   H4↓, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 3,   HDAC3↓, 1,   miR-124-3p↓, 1,   OCT4↓, 2,   other↓, 1,   other↑, 3,   PAX2↓, 1,   SOX2↓, 2,   SOX9↓, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 4,   eIF2α↑, 1,   p‑eIF2α↑, 2,   ER Stress↑, 4,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 2,   HSP90↓, 3,   NQO2↑, 1,   PERK↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 6,   P53↓, 1,   P53↑, 8,   P53↝, 1,   PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 6,   PCNA↓, 6,   TOP2↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   p‑CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 6,   CDK6↓, 2,   CDK6↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 8,   Ki-67↓, 5,   mitA↑, 1,   P21↑, 6,   p27/CDKN1B↑, 1,   pRB↓, 1,   p‑RB1↓, 1,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   BMP7/OP1↓, 2,   CD34↓, 1,   cFos↑, 1,   CSCs↓, 3,   Diff↓, 1,   EIF4E↓, 1,   FGF↓, 1,   Ki-67↓, 5,   Nanog↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   TumCG↓, 6,   TumCG↑, 1,   TumCP↓, 20,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   cal2↓, 1,   Cdc42↓, 1,   Cofilin↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 4,   EMT↓, 10,   FAK↓, 1,   fascin↓, 1,   GIT1↓, 1,   ITGB1↓, 1,   KRAS↓, 2,   LAMs↓, 1,   LIMK2↓, 1,   MALAT1↓, 1,   MET↓, 1,   MET↑, 1,   p‑MET↓, 1,   MMP2↓, 9,   MMP7↓, 1,   MMP9↓, 10,   MMPs↓, 6,   N-cadherin↓, 4,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TET1↑, 1,   TGF-β↓, 2,   TIMP1↑, 1,   TIMP2↑, 3,   pol-TregCell↓, 1,   TumCA↓, 1,   TumCI↓, 6,   TumCMig↓, 12,   TumMeta↓, 9,   Twist↓, 3,   Tyro3↓, 1,   Vim↓, 3,   Vim↑, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   angioG↑, 1,   EGR4↓, 1,   Hif1a↓, 5,   NO↓, 1,   VEGF↓, 14,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↓, 1,   MMP↓, 3,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 1,   CD47↓, 1,   CD8+↑, 3,   COX2/PTGS2↓, 8,   CXCR3↓, 1,   CXCR4↓, 1,   DR4↑, 1,   HCAR2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IL2↑, 1,   IL6↓, 4,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 5,   LPS↓, 1,   MyD88↓, 1,   NF-kB↓, 16,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 3,   NLRP3↓, 3,   NLRP3↑, 1,   p65↓, 1,   p‑p65↓, 2,   PD-1↓, 2,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 1,   TLR4↓, 3,   TNF-α↓, 3,   TRIF↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   PPARγ↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 3,   ChemoSen↑, 21,   CompStab↝, 1,   CYP1A1↓, 1,   Dose↝, 8,   eff↑, 7,   eff⇅, 1,   eff∅, 1,   Half-Life↓, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,   RadioS↑, 6,   selectivity↑, 9,   Synergy↑, 15,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 2,   CA19-9↓, 1,   CEA↓, 3,   CRP↓, 2,   EGFR↓, 2,   EGFR↑, 2,   EZH2↓, 2,   FOXM1↓, 2,   HER2/EBBR2↓, 2,   IL6↓, 4,   IL6↑, 1,   KRAS↓, 2,   LDH↓, 1,   LDH↑, 1,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 11,   AntiTum↑, 5,   cachexia↓, 2,   cardioP↑, 2,   chemoP↑, 9,   chemoPv↑, 1,   cognitive?, 1,   cognitive↑, 2,   hepatoP↑, 2,   K17↓, 1,   neuroP↑, 3,   NP/CIPN↓, 2,   PFS↑, 1,   QoL↑, 3,   radioP↑, 3,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 378

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx↓, 4,   antiOx↑, 86,   ARE↑, 4,   Bil↓, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 70,   Copper↓, 1,   DPPH↓, 1,   DUOX1↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↓, 1,   GPx↑, 42,   GPx1↑, 1,   GPx4↑, 3,   GSH↑, 77,   GSR↓, 3,   GSR↑, 8,   GSSG↓, 1,   GSTs↓, 4,   GSTs↑, 9,   H2O2↓, 5,   HDL↓, 1,   HDL↑, 3,   HNE↓, 1,   HO-1↓, 3,   HO-1↑, 69,   HO-2↓, 1,   hyperG↝, 1,   Iron↓, 2,   Keap1↓, 3,   Keap1↑, 1,   Keap1↝, 2,   lipid-P↓, 51,   mt-lipid-P↓, 1,   MDA↓, 72,   MPO↓, 12,   NOX↓, 2,   NOX1↓, 1,   NOX2↓, 3,   NOX4↓, 5,   NQO1↑, 17,   NQO1↝, 1,   Nrf1↑, 1,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 97,   Prx↑, 1,   RNS↓, 4,   ROS?, 3,   ROS↓, 148,   ROS⇅, 1,   mt-ROS?, 1,   mt-ROS↓, 5,   SOD?, 1,   SOD↓, 1,   SOD↑, 96,   SOD1↑, 6,   SOD2↑, 2,   TAC↑, 10,   TBARS↓, 4,   Thiols↑, 1,   Trx1↑, 1,   TrxR↑, 2,   UCPs↑, 1,   uricA↓, 1,   VitC↑, 5,   VitE↓, 1,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 8,   Mets↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↑, 1,   FIS1↓, 1,   Insulin↑, 3,   MFN1↓, 1,   MFN2↓, 1,   mitResp↑, 1,   mtDam↓, 6,   OPA1↓, 1,   OXPHOS↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   PINK1↓, 1,   PINK1↑, 1,   SIRT3↑, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 7,   ACADS/SCAD↑, 1,   ACC↑, 1,   ACSL4↓, 1,   adiP↓, 1,   adiP↑, 1,   ALAT↓, 18,   AMPK↑, 13,   ATP↑, 12,   cAMP↑, 2,   CPT1A↑, 1,   CRM↑, 1,   FABP4↓, 1,   FAM↑, 1,   G6PD↑, 1,   glucose↓, 2,   glucose↝, 1,   GlucoseCon↑, 2,   GSK‐3β↓, 15,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   H2S↑, 1,   HMG-CoA↓, 1,   LDL↓, 11,   lipidLev↓, 1,   NAD↑, 1,   NADH:NAD↑, 1,   NADPH↓, 7,   NADPH↑, 3,   PKM2↓, 2,   SIRT1↑, 15,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 25,   ASC?, 1,   ASC↓, 5,   BAD↓, 1,   BAX↓, 17,   BAX↑, 1,   Bax:Bcl2↓, 3,   Bcl-2↓, 5,   Bcl-2↑, 13,   Bcl-xL↑, 1,   BNIP3↓, 1,   Casp1?, 1,   Casp1↓, 8,   cl‑Casp1↓, 2,   proCasp1↓, 1,   Casp12↓, 2,   Casp3↓, 35,   Casp3↑, 2,   cl‑Casp3↓, 3,   Casp6↓, 1,   Casp8↓, 2,   cl‑Casp8↓, 1,   Casp9↓, 16,   Casp9↑, 1,   Cyt‑c↓, 5,   Cyt‑c∅, 1,   Fas↓, 1,   Ferroptosis↓, 4,   GranB/GZMB↓, 1,   GSDMD↓, 3,   iNOS↓, 60,   iNOS↑, 2,   MLKL↓, 1,   necrosis↓, 2,   p38↓, 10,   p‑p38↓, 1,   Pyro?, 1,   Pyro↓, 1,   survivin↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   Akt↑, 11,   p‑Akt↑, 2,   AKT1↓, 1,   AMPKα↑, 1,   CaMKII ↓, 1,   CREB↓, 1,   CREB↑, 3,   p‑CREB↑, 1,   EGFR↓, 2,   ERK↓, 9,   ERK↑, 3,   p‑ERK↓, 1,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 1,   p‑IKKα↓, 2,   JAK↓, 1,   p‑JAK1↓, 1,   JAK2↓, 1,   JAK2↑, 2,   p‑JAK2↓, 1,   JNK↓, 9,   JNK↑, 1,   p‑JNK↓, 5,   MAPK?, 1,   MAPK↓, 21,   MAPK↑, 3,   MAPK↝, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 5,   mTOR↑, 2,   p‑mTOR↓, 2,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 6,   PI3K↑, 7,   PKA↑, 1,   PKCδ?, 1,   PKCδ↓, 2,   PKCδ↑, 2,   PP2A↑, 1,   PTEN↓, 2,   RIP1↓, 2,   STAT↓, 1,   STAT3↓, 6,   STAT3↑, 3,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF4↓, 2,   cMyc↓, 1,   FOXO↑, 1,   FOXO3↑, 2,   HDAC↓, 2,   HDAC↑, 1,   HDAC2↓, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   other↓, 3,   other↑, 8,   other↝, 14,   SOX9↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 7,   CHOP/DDIT3↑, 1,   p‑eIF2α↓, 2,   ER Stress↓, 8,   GRP78/BiP↓, 6,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 6,   HSP70/HSPA5↝, 1,   HSPs↑, 1,   IRE1↓, 2,   PERK↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↓, 1,   autophagy↓, 1,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,   LC3B↑, 1,   LC3II↑, 1,   MitoP↓, 1,   MitoP↑, 1,   p62↓, 1,   p62↑, 2,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   P53↓, 1,   PARP1↓, 1,   PCNA↓, 2,   Telomerase↓, 1,   TOP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   cycD1/CCND1↓, 1,   Ki-67↓, 2,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   Choline↑, 1,   Diff↑, 1,   FGF↑, 1,   IGF-1↑, 1,   Ki-67↓, 2,   MSCs↑, 1,   neuroG↑, 5,   p‑STAT1↓, 1,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 3,   AntiAg↑, 5,   AP-1↓, 5,   ARG1/2↑, 1,   BACH1↓, 1,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 4,   COL1↓, 2,   COL2A1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   EMT↓, 2,   LRP1↑, 1,   MMP1↓, 1,   MMP13↓, 3,   MMP2↓, 3,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 15,   MMP9↑, 1,   MMPs↓, 3,   MUC1↑, 2,   Rho↓, 2,   ROCK1↓, 2,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 4,   TGF-β1↓, 1,   TGF-β1↑, 2,   TIMP1↓, 2,   TIMP2↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   Twist↑, 1,   TXNIP↓, 3,   TXNIP↑, 1,   uPA↑, 1,   Vim↓, 1,   Vim↑, 1,   Zeb1↓, 1,   α-SMA↓, 5,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   angioG↝, 1,   E-sel↓, 3,   eNOS↑, 2,   LOX1↓, 1,   NO↓, 40,   NO↑, 2,   VCAM-1↓, 9,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 27,   BBB↝, 4,   BBB∅, 2,   CLDN1↓, 1,   CLDN1↑, 1,   CLDN4↑, 1,   GastroP↑, 3,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 5,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 18,   MUC19↓, 1,   MUC2↓, 1,   MUC2↑, 1,   OCLN↓, 1,   OCLN↑, 5,   TJ↑, 4,   TRPA1↑, 1,   TRPM7↓, 1,   TRPV1↑, 2,   VGSC↓, 1,   ZO-1↓, 2,   ZO-1↑, 8,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   AIM2↓, 2,   CB2 / CNR2↑, 4,   CD25+↑, 1,   CD4+↑, 3,   CD8+↑, 1,   COX1↓, 6,   COX1↑, 1,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 82,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR4↓, 2,   FOXP3↑, 2,   HMGB1↓, 6,   ICAM-1↓, 13,   IFN-γ↓, 12,   IFN-γ↑, 2,   IL1↓, 2,   IL10↓, 8,   IL10↑, 26,   IL12↓, 5,   IL17↓, 11,   IL18↓, 11,   IL1β↓, 247,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 2,   IL4↓, 7,   IL4↑, 4,   IL5↓, 2,   IL6?, 1,   IL6↓, 141,   IL6↑, 4,   IL8↓, 22,   IL8↑, 1,   Imm↑, 5,   Imm↝, 1,   INF-γ↓, 3,   Inflam↓, 160,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 4,   LPS↓, 2,   LTA/TNF-β↑, 1,   M1↓, 1,   M2 MC↑, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 13,   MCP1/CCL2↑, 1,   MIP‑1α/CCL3↓, 2,   MIP2↓, 2,   MyD88↓, 5,   NeuroI↓, 2,   NF-kB↓, 106,   p‑NF-kB↓, 1,   NLRP3↓, 40,   NOD1↓, 1,   p65↓, 3,   PGE2↓, 33,   PGE2↑, 1,   PSA↓, 1,   RAGE↓, 2,   RANTES↓, 2,   SOCS-3↓, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 6,   TLR4↓, 28,   TLR4↑, 1,   TNF-α↓, 199,   TNF-α↑, 1,   TRAF1↓, 1,   Treg lymp↝, 1,   TRIF↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 9,   Ach↑, 11,   AChE↓, 31,   BChE↓, 8,   BDNF↑, 33,   BDNF∅, 2,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   DA↑, 1,   GABA↑, 2,   GABA↝, 1,   MAOA↓, 7,   MAOB↓, 2,   NGF↑, 4,   PSD95↑, 3,   SNAP25↑, 2,   SYP↑, 1,   TrkB↑, 6,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 6,   Aβ↓, 50,   Aβ42↓, 3,   BACE/β-secretase↓, 21,   tau↓, 11,   p‑tau↓, 11,   XO↓, 2,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   BNP↓, 1,   DHT↓, 1,   ER(estro)↓, 1,   GR↑, 1,   PPARα↑, 5,   PPARγ↓, 2,   PPARγ↑, 13,   p‑PPARγ↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 34,   BioAv↝, 19,   BioEnh↑, 3,   ChemoSen↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 25,   eff↓, 4,   eff↑, 21,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 2,   Half-Life↑, 5,   Half-Life↝, 13,   P-gp/ABCB1↓, 2,   P450↑, 1,   P450↝, 1,   Synergy↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 18,   ALB↑, 1,   ALP↓, 4,   AST↓, 19,   BG↓, 3,   Bil↓, 1,   Bil↑, 2,   BloodF↑, 3,   BMD↑, 1,   BP↓, 7,   BP∅, 1,   BUN?, 1,   BUN↓, 5,   CEA↓, 1,   creat↓, 9,   CRP↓, 8,   EGFR↓, 2,   Ferritin↑, 1,   Hcy/homoC↓, 1,   HemoG↑, 1,   IL6?, 1,   IL6↓, 141,   IL6↑, 4,   LDH↓, 9,   NOS2↓, 3,   PSA↓, 1,   RAGE↓, 2,   SpO2↑, 1,   TG/TAG↓, 2,   TMAO↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 2,   AntiAge↑, 5,   antiAll?, 1,   antiAll↑, 16,   AntiArt↑, 4,   AntiCan↑, 8,   antiCG↑, 2,   AntiDiabetic↑, 9,   antiPs↑, 2,   AntiTum↑, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 38,   chemoP↑, 7,   chemoPv↑, 3,   cognitive↑, 60,   diuretic↑, 1,   hepatoP↑, 40,   Learn↑, 7,   memory↑, 52,   Mood↑, 1,   motorD↓, 2,   motorD↑, 13,   neuroP↑, 105,   NP/CIPN↓, 1,   Obesity↓, 6,   OS↑, 5,   Pain↓, 9,   PDE4↓, 1,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 21,   Risk↓, 6,   Sleep↑, 2,   Strength↑, 4,   Stress↓, 1,   Stroke↓, 16,   toxicity↓, 17,   toxicity↝, 1,   toxicity∅, 6,   Weight↓, 1,   Weight↑, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 8,   AntiFungal↑, 6,   AntiViral↑, 8,   Bacteria↓, 11,   Diar↓, 2,   GutMicro↑, 23,   GutMicro↝, 1,   Inf↓, 1,   Sepsis↓, 8,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Ingr↝, 3,   Phen↑, 1,   QC↑, 1,  
Total Targets: 601

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
16 Thymoquinone
9 Curcumin
8 Hydrogen Gas
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Lycopene
7 Magnetic Fields
6 Alpha-Lipoic-Acid
6 Luteolin
5 Silymarin (Milk Thistle) silibinin
4 Beta-Caryophyllene
4 Ferulic acid
4 isoorientin
4 Matrine
4 Propolis -bee glue
4 Resveratrol
4 Shikonin
4 Urolithin
3 1,8-Cineole
3 Ashwagandha(Withaferin A)
3 Baicalein
3 α-Bisabolol / Chamomile oil
3 Cichoric acid / Chicoric acid
3 Formononetin
3 Gallic acid
3 Honokiol
3 Hyperoside
3 Isoliquiritigenin
3 Isovitexin
3 Rosmarinic acid
3 Rutin
2 Baicalin
2 Berberine
2 Betulinic acid
2 Boron
2 Boswellia (frankincense)
2 Capsaicin
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Chlorogenic acid
2 Chrysin
2 Echinacea
2 Crocetin
2 Radiotherapy/Radiation
2 EGCG (Epigallocatechin Gallate)
2 Eugenol
2 Phosphatidylserine
2 Fisetin
2 Chemotherapy
2 Linalool
2 Lutein
2 Morin
2 Methylsulfonylmethane
2 Phenylbutyrate
2 Piperine
2 Pterostilbene
2 Vitamin C (Ascorbic Acid)
1 Açaí, Euterpe oleracea
1 Anthocyanins
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Aloe anthraquinones
1 Biochanin A
1 xanthohumol
1 borneol
1 Selenium
1 Butyrate
1 Carnosic acid
1 Carnosine
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 Chyawanprash
1 Citicoline, CDP-Choline
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Date Fruit Extract
1 Dihydrocaffeic Acid
1 Diindolylmethane
1 Indole-3-carbinol
1 D-limonene
1 Dandelion Root
1 Emodin
1 eicosapentaenoic acid
1 methotrexate
1 Folic Acid, Vit B9
1 Fucoidan
1 Gamma-aminobutyric acid
1 Ginkgo biloba
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Isorhamnetin
1 isoquercitrin
1 Kaempferol
1 L-Theanine
1 Magnolol
1 Mung Bean Sprouts
1 Magnesium
1 Melatonin
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 Nimbolide
1 Oleocanthal
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 α-Santalol/Sandalwood oil
1 Selenium NanoParticles
1 Sesame seeds and Oil
1 Terpinen-4-ol / Tea Tree Oil
1 5-fluorouracil
1 Vitamin B1/Thiamine
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 Vitamin K2
1 Vitexin
1 Zeaxanthin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:978  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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