COX1 Cancer Research Results

COX1, COX-1: Click to Expand ⟱
Source:
Type:
COX‑1 is traditionally considered a constitutively expressed enzyme involved in “housekeeping” functions, while COX‑2 is more frequently studied in relation to cancer.
• The prognostic impact of COX‑1 may vary based on cancer subtype, stage, and interplay with other inflammatory mediators (e.g., COX‑2).
• Many studies assess combined cyclooxygenase profiles (COX‑1/COX‑2) rather than COX‑1 alone.
Scientific Papers found: Click to Expand⟱
5312- acet,    Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
- Review, Nor, NA
*COX1↓, *other?, *BBB↑, TRPV1↑,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓, *antiAll↑,
5414- ASA,    Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
- Review, Var, NA
Risk↓, *toxicity↓, other↑, *COX1↓, TumCP↓, DNArepair↑, ChemoSen↑, other↓,
5413- ASA,    Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin
- Trial, Nor, NA
*cardioP↑, *other↝, *COX1↓, *TXA2↓,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, Nor, NA
*COX1↓, *COX2/PTGS2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5411- ASA,    Mechanistic Insights into a Classic Wonder Drug—Aspirin
- Review, Var, NA
*COX2/PTGS2↓, *COX1↓, *Inflam↓, *cardioP↑, Risk↓,
5400- ASA,    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
- Review, Nor, NA
Risk↓, *Inflam↓, *COX1↓, *AntiAg↑, *Half-Life↓, *BioAv↑,
5401- ASA,    Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15R-prostaglandins that inhibit platelet aggregation
- Review, Nor, NA
*AntiAg↑, *COX1↓,
2461- ASA,    Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis
- Review, Nor, NA
*AntiAg↑, *COX1↓, *eff↑,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓, *antiAll↑,
4342- CA,    Antiplatelet effects of caffeic acid due to Ca(2＋) mobilizationinhibition via cAMP-dependent inositol-1, 4, 5-trisphosphate receptor phosphorylation
- in-vitro, Nor, NA
*AntiAg↑, *TXA2↓, *COX1↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
6702- DFC,    Diclofenac
- Review, Nor, NA
*Inflam↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *TXA2↓, *BioAv↑, *Dose↝, *cardioP↓,
6703- DFC,    Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
- Analysis, Var, NA
*Inflam?, *COX1↓, *COX2/PTGS2↓, GLUT1↓, MCT4↓, LDHA↓, ABCG2↓, MDM2↓, MRP1/ABCC1↓, SOD2↓, Myc↓, β-catenin/ZEB1↓, VEGF↓, IKKα↓, cJun↓, E2Fs↓,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2/PTGS2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
6730- Dipy,  ASA,    Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
- vitro+vivo, CRC, NA
*AntiThr↑, Synergy↑, ER Stress↑, UPR↑, *AntiAg↑, *COX1↓, Risk↓, TumCG↓, Apoptosis↑, HMG-CoA↓, *Inflam↓, *antiOx↓,
6634- Ech,    Echinacea purpurea: Pharmacology, phytochemistry and analysis methods
- Review, Var, NA
AntiArt↑, *Imm↑, *Neut↑, *NK cell↑, *COX1↓, *COX2/PTGS2↓, *Inflam↓, TumCG↑, *toxicity↓,
2563- EGCG,    Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies
- Review, Stroke, NA
*cardioP↑, *ROS↓, *AntiAg↑, *eff↑, *COX1↓,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, Nor, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2/PTGS2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓, *antiAll↑,
3589- PI,    Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
- in-vivo, Arthritis, NA
*IL6↓, *MMP13↓, *PGE2↓, *AP-1↓, *Inflam↓, *5LO↓, *COX1↓, *COX2/PTGS2↓, *ERK↓, *BioEnh↑,
3595- PI,    Black pepper and health claims: a comprehensive treatise
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *chemoP↑, TumCG↓, *cognitive↑, *MMPs↓, *PGE2↓, *AP-1↓, *5LO↓, *COX1↓, *other↑, *other↑, *other↑, *SOD↑, *Catalase↑, *GSTs↑, *GSR↑, *other↑, *Weight↓, *BioEnh↑, *BioAv↑, *Synergy↑, *CYP3A2↓, *neuroP↑, *BP↓, *other↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

Showing Research Papers: 1 to 26 of 26

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 26

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   H2O2↑, 1,   lipid-P↑, 1,   ROS↓, 1,   ROS↑, 4,   i-ROS↑, 1,   SOD2↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   ETC↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   AMPK↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   MCT4↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 3,   BAX↑, 3,   Bcl-2↓, 1,   BNIP3↝, 1,   Casp3↑, 4,   Casp8↑, 3,   Casp9↑, 2,   Cyt‑c↑, 2,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   ICAD↓, 1,   iNOS↓, 1,   MDM2↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   cMET↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   IKKα↓, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PKCδ↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   DNMT1↓, 1,   FOXM1↓, 1,   Myc↓, 2,   MYCN↓, 1,   other↓, 1,   other↑, 1,   SOX9↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNArepair↑, 1,   p73↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   p‑CDK1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   E2Fs↓, 1,   P21↑, 2,   p‑RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   TumCG↓, 2,   TumCG↑, 1,   TumCP↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 2,   cal2↓, 1,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   Hif1a↓, 1,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   MMP↓, 1,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   NF-kB↓, 2,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 1,   ChemoSen↑, 4,   Dose↝, 1,   MRP1/ABCC1↓, 2,   P-gp/ABCB1↓, 1,   RadioS↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   FOXM1↓, 1,   Myc↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 6,   Risk↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 127

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 2,   MDA↓, 3,   NADH↓, 1,   NRF2↑, 1,   Prx↑, 1,   RNS↓, 1,   ROS↓, 8,   SOD↑, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

15-LOX/ALOX15↓, 1,   5LO↓, 3,   LDL↓, 2,  

Cell Death(tgid=5) ⓘ

Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   iNOS↓, 3,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   ERK↓, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other?, 1,   other↓, 1,   other↑, 10,   other↝, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 10,   AP-1↓, 3,   MMP13↓, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TGF-β↓, 2,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

LOX1↓, 1,   NO↓, 2,   NO↑, 1,   TXA2↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 2,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   COX1↓, 26,   COX2/PTGS2↓, 15,   CXCR4↓, 1,   IL10↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 6,   IL4↑, 1,   IL6↓, 5,   IL8↓, 1,   Imm↑, 3,   Inflam?, 1,   Inflam↓, 13,   Neut↑, 1,   NF-kB↓, 3,   NK cell↑, 1,   PGE2↓, 5,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 1,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 2,  

Protein Aggregation(tgid=19) ⓘ

tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARα↑, 2,   PPARγ↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 7,   BioAv↝, 4,   BioEnh↑, 3,   CYP3A2↓, 1,   Dose⇅, 1,   Dose↝, 2,   eff↑, 3,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 3,   CRP↓, 1,   IL6↓, 5,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 3,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 3,   cardioP↓, 1,   cardioP↑, 6,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 6,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   toxicity↓, 3,   toxicity↝, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   Bacteria↓, 1,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 126

Scientific Paper Hit Count for: COX1, COX-1
8 Aspirin
3 Diclofenac
2 Beta-Caryophyllene
2 Piperine
1 acetaminophen
1 Allicin (mainly Garlic)
1 xanthohumol
1 Boswellia (frankincense)
1 Caffeic acid
1 Celastrol
1 Date Fruit Extract
1 Dipyridamole
1 Echinacea
1 EGCG (Epigallocatechin Gallate)
1 Propolis -bee glue
1 Rutin
1 buckwheat sprouts
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:998  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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