toxicity Cancer Research Results

toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
Scientific Papers found: Click to Expand⟱
5302- 5-HTP,    Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report
- Case Report, Nor, NA
*toxicity↑, *Dose↑,
5294- 5-HTP,    Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan
- in-vivo, Nor, NA
*toxicity↑,
7397- Amla,    Clinical evaluation of Emblica Officinalis Gatertn (Amla) in healthy human subjects: Health benefits and safety results from a randomized, double-blind, crossover placebo-controlled study
- Trial, Nor, NA
*Dose↝, *other↑, *LDL↓, *HDL↑, *toxicity↑, *ROS↓,
5572- B-Gluc,    The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
- Study, Nor, NA
Imm↑, *Dose↝, *BioAv↓, *toxicity↑,
932- BBR,    The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity
- in-vivo, Nor, NA
*glucoNG↓, *Glycolysis↑, *NH3↑, *NADPH/NADP+↑, *ATP↓, *toxicity↑,
7978- BUL,    Synthesis and Cytotoxic Property of Annonaceous Acetogenin Glycoconjugates
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549 - in-vitro, Liver, HepG2
*toxicity↑, *BioAv↑,
7976- BUL,    Antitumor activity and toxicity relationship of annonaceous acetogenins
- in-vitro, HCC, H22
toxicity↓, TumCG↓, *toxicity↑, *ROS↑, *Ca+2↑, *BAX↑,
6177- Cu,    Toxicity of copper oxide nanoparticles: a review study
- Review, Nor, NA
*ROS↑, *Inflam↑, *toxicity↑, lipid-P↑, GSH↓, MDA↑, *SOD↓, *Catalase↓,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27/CDKN1B↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
6425- ESTr,    Assessing the Risk of Estragole Consumption From Natural Products in the Malaysian Market by Using the Margin of Exposure Approach
- Review, Nor, NA
*toxicity↑, *Dose↝,
6850- FBZ,    Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information
- Case Report, Lung, NA
*toxicity↑, Dose↑,
6851- FBZ,    Severe Drug-Induced Liver Injury Due to Self-administration of the Veterinary Anthelmintic Medication, Fenbendazole
- Case Report, Var, NA
*toxicity↑, Dose↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
7204- GAs,    The Pharmacology and Toxicology of Ginkgolic Acids: Secondary Metabolites from Ginkgo biloba
- Review, Nor, NA
AntiTum↑, SUMO↓, antiNeop↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *toxicity↑, *ROS↑, *toxicity↝,
7101- Geld,    Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs
- in-vitro, Nor, NA
*toxicity↑, *AntiBio↑, HSP90↓, AntiCan↑,
7098- Geld,    Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
- Review, Var, NA
HSP90↓, *toxicity↑, *toxicity↓, *BioAv↑, eff↑, *toxicity↓, other↝,
7097- Geld,    Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry
- Review, Var, NA
HSP90↓, *Bacteria↓, *toxicity↑,
7108- GEN,    Genistein: A Review on its Anti-Inflammatory Properties
- Review, Nor, NA
*cardioP↑, *Inflam↓, *NF-kB↓, *PGE2↓, *iNOS↓, *ROS↓, *COX2/PTGS2↓, *toxicity↑,
7113- GEO2,    Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide
- Review, Nor, NA
*Dose↓, *Dose↑, *toxicity↑, *creat↑, *Dose↑, *other?,
7116- GEO2,    Analytical product study of germanium-containing medicine by different ICP-MS applications
- Study, Nor, NA
*toxicity↓, *toxicity↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
2079- HNK,    Honokiol Microemulsion Causes Stage-Dependent Toxicity Via Dual Roles in Oxidation-Reduction and Apoptosis through FoxO Signaling Pathway
- in-vitro, Nor, PC12
*toxicity↝, *ROS↓, *ROS↑, *Dose⇅, *BioAv↑, *BioAv↓, *ROS⇅, *SOD↓, *toxicity↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- in-vitro, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8166- LapC,    Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model
- vitro+vivo, BC, NA
BioAv↓, *toxicity↑, eff↑,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,
8559- Matr,    Matrine induces toxicity in mouse liver cells through an ROS-dependent mechanism
- vitro+vivo, Nor, NA
*Dose↝, *toxicity↑, *Casp3↑, *Casp9↑, *ROS↑, *MMP↓, *ATP↓, *eff↓,
8553- Matr,    Research progress on the pharmacological effects of matrine
- Review, Nor, NA
*AntiCan↑, *antiAll↑, *Stroke↓, TumCI↓, TumCMig↓, TumCP↓, TumCCA↑, *AGEs↓, *Inflam↓, *antiOx↑, *neuroP↑, *Apoptosis↓, *IBI↑, *GutMicro↑, EGFR↓, *HSP60/HSPD1↓, *antiOx↑, *GSH↑, *Catalase↑, *AChE↓, *BChE↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *cognitive↑, *ROS↓, *toxicity↑,
8551- Matr,    Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
- Review, Nor, NA
*BioAv↓, *toxicity↑, *AntiTum↑, *AntiViral↑, *Inflam↓, *hepatoP↑, *Analgesic↑, *Half-Life↓, *toxicity↓,
6541- MeSal,    Toxicology Answer: Oil of Wintergreen
- Review, Nor, NA
*Inflam↓, *Pain↓, *BioAv↝, *BloodF↑, *toxicity↑,
8941- MushCha,    Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report
- Case Report, AKI, NA
*toxicity↑,
1665- PBG,    Evidence on the Health Benefits of Supplemental Propolis
- Review, Nor, NA
*antiOx↑, *Inflam↓, *toxicity↑, *Dose?,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
1706- SSE,    Selenium in Prostate Cancer: Prevention, Progression, and Treatment
- Review, Pca, NA
Risk∅, ChemoSen↑, Risk↓, toxicity↝, Risk↑, Synergy↑, *toxicity↑, RadioS↑, eff↓, eff↑, ChemoSen↑, ChemoSideEff↓,
6768- T4O,    Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
- Review, Nor, NA
*AntiBio↑, *other↝, *AntiFungal↑, *Inflam↓, *ROS⇅, *toxicity↑,
2283- VitK2,    Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response
- Review, Var, NA
*ER Stress↓, *toxicity↓, *toxicity↑, ROS↑, PI3K↑, Akt↑, Hif1a↑, GlucoseCon↑, lactateProd↑, ChemoSen↑, Synergy↑, Synergy↑,

Showing Research Papers: 1 to 38 of 38

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 38

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 1,   MDA↑, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↑, 6,   SOD↑, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↓, 1,   GlucoseCon↑, 1,   lactateProd↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 6,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 2,   cl‑Casp3↑, 3,   proCasp3↓, 1,   cl‑Casp9↑, 3,   Cyt‑c↑, 3,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   MOMP↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 1,   EGFR↓, 1,   ERK↓, 1,   IKKα↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↑, 1,   PI3K/Akt↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   SUMO↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   MitoP↑, 1,   PARK2↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 2,   P21↑, 1,   p27/CDKN1B↑, 2,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

NOTCH↓, 1,   TumCG↓, 3,   TumCP↓, 3,  

Migration(tgid=13) ⓘ

EMT↓, 1,   p‑FAK↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumMeta↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 1,   Hif1a↑, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   EPR↑, 1,   MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Imm↑, 2,   NF-kB↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 5,   CYP3A4↓, 1,   Dose?, 1,   Dose↑, 2,   Dose↝, 2,   eff↓, 5,   eff↑, 4,   RadioS↑, 2,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↑, 3,   chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   Risk↓, 2,   Risk↑, 1,   Risk∅, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 2,  
Total Targets: 109

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↓, 1,   Catalase↑, 2,   GSH↑, 2,   HDL↑, 1,   lipid-P↓, 1,   NADPH/NADP+↑, 1,   ROS↓, 5,   ROS↑, 5,   ROS⇅, 2,   SOD↓, 2,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

HSP60/HSPD1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ATP↓, 2,   glucoNG↓, 1,   Glycolysis↑, 1,   LDL↓, 1,   NH3↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Casp3↑, 1,   Casp9↑, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   mTOR↑, 1,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL6↑, 1,   Inflam↓, 11,   Inflam↑, 1,   NF-kB↓, 2,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 1,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 5,   BioAv↝, 1,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 5,   eff↓, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   creat↑, 1,   IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   antiAll↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 2,   neuroP↑, 5,   Pain↓, 1,   Strength↑, 1,   Stroke↓, 1,   toxicity↓, 5,   toxicity↑, 38,   toxicity↝, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   AntiP↑, 1,   AntiViral↑, 3,   Bacteria↓, 2,   GutMicro↑, 1,  
Total Targets: 88

Scientific Paper Hit Count for: toxicity, toxicity
3 Geldanamycin
3 Matrine
2 5-Hydroxytryptophan
2 Bullatacin
2 Fenbendazole
2 Germanium inorganic
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 beta-glucans
1 Berberine
1 Copper and Cu NanoParticles
1 Cucurbitacin
1 Deguelin
1 Emodin
1 Estragole
1 Fisetin
1 Shilajit/Fulvic Acid
1 Ginkgolic acids
1 Genistein (soy isoflavone)
1 Ginkgetin
1 Honokiol
1 Ivermectin
1 Lapachol
1 Luteolin
1 Apigenin (mainly Parsley)
1 EGCG (Epigallocatechin Gallate)
1 Resveratrol
1 Methyl salicylate / Sweet Birch oil
1 Mushroom Chaga, Inonotus obliquus
1 Propolis -bee glue
1 Selenium
1 chitosan
1 Selenite (Sodium)
1 Terpinen-4-ol / Tea Tree Oil
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1025  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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