GSTA1 Cancer Research Results

GSTA1, Glutathione S-Transferase A1: Click to Expand ⟱
Source:
Type:
GSTA1 belongs to the glutathione S-transferase (GST) superfamily of enzymes. These enzymes catalyze the conjugation of glutathione (GSH) to a variety of electrophilic substrates, thereby aiding in their detoxification.
By facilitating the detoxification of reactive metabolites, carcinogens, and drugs, GSTA1 helps protect cells against oxidative stress and chemical-induced damage.
In tumor cells, upregulation of GSTA1 may be a defensive response to increased oxidative stress. While this can protect normal cells, in a tumor setting, enhanced detoxification may allow cancer cells to survive in a hostile microenvironment.
Elevated levels of GSTA1 have been linked to resistance to chemotherapy. As GSTA1 helps metabolize and clear chemotherapeutic agents, its overexpression in tumors can contribute to treatment resistance
-GSTA1 expression levels are being evaluated as a prognostic marker. In some studies, its overexpression has correlated with aggressive tumor behavior, higher rates of recurrence, and reduced overall survival.
Scientific Papers found: Click to Expand⟱
4385- AgNPs,    Hepatoprotective effect of engineered silver nanoparticles coated bioactive compounds against diethylnitrosamine induced hepatocarcinogenesis in experimental mice
- in-vitro, Liver, NA
hepatoP↑, *AST↓, *ALAT↓, *Catalase↑, *GPx↑, *GSTA1↑, *SOD↑,
7944- BuckWS,    Extracts from Tartary Buckwheat Sprouts Restricts Oxidative Injury Induced by Hydrogen Peroxide in HepG2 by Upregulating the Redox System
- in-vitro, Nor, HepG2
*ROS↓, *MMP↑, *TAC↑, *SOD↑, *Catalase↑, *GSTA1↑, *NRF2↑, *NQO1↑, *HO-1↑,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *Synergy↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
3221- EGCG,    EGCG upregulates phase-2 detoxifying and antioxidant enzymes via the Nrf2 signaling pathway in human breast epithelial cells
- in-vitro, Nor, MCF10
*antiOx↑, *GSTA1↑, *NRF2↑,
9072- L-THE,  doxoR,    Protective effects of L-theanine against doxorubicin-induced nephrotoxicity in rats
- in-vivo, Nor, NA
*Dose↝, *GSSG↓, *GGT/CD224↓, *NF-kB↓, *GSH↑, *GPx↑, *GSR↑, *GSTA1↑, *chemoP↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4231- LT,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
8434- OM,    Traditional use, phytochemistry, toxicology, and pharmacology of Origanum majorana L
- Review, Var, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *AntiP↑, *AntiDiabetic↑, *AntiCan↑, *RenoP↑, *Inflam↓, *Analgesic↑, *antiPy↑, *antiM↑, *Ingr↝, *Ingr↝, *creat↓, *Urea↓, *uricA↓, *BUN↓, *ALAT↓, *AST↓, *ALP↓, *Catalase↑, *SOD↑, *GSTA1↑,
2554- SFN,    Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm
- Review, Var, NA
Dose↝, chemoPv↑, *NQO1↑, *GSTA1↑, HDAC↓, NF-kB↓,
1431- SFN,    Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
- in-vivo, Nor, NA
*NADPH↑, *NQO1↑, *GSTA1↑, *HO-1↑,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, Nor, NA
*COX2/PTGS2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
2137- TQ,    Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats
- in-vivo, Nor, NA
*GSH↑, *SOD↑, *GSTA1↑,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   ROS↑, 1,   ROS⇅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

FASN↓, 1,   GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↑, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   DR5↑, 1,   Fas↑, 1,   p38↑, 1,   survivin↓, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 1,   ERK↓, 2,   JNK↑, 2,   MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PKCδ↓, 1,   PTEN↑, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   HDAC↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,   TOP1↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   p27/CDKN1B↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 1,   FAK↓, 1,   MMP1↓, 1,   MMP9↓, 1,   MMPs↓, 1,   PDGF↓, 1,   TumMeta↓, 2,   Twist↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   Hif1a↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 3,   p‑NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   CYP1A1↓, 1,   CYP1A2↓, 1,   Dose↝, 2,   P450↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   hepatoP↑, 1,  
Total Targets: 69

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↑, 6,   GCLC↑, 1,   GPx↑, 3,   GSH↑, 3,   GSR↑, 2,   GSSG↓, 1,   HO-1↑, 3,   MDA↓, 1,   MDA↑, 1,   NQO1↑, 4,   NRF2↑, 2,   ROS↓, 3,   SOD↑, 8,   TAC↑, 2,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   NADPH↑, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↓, 1,   other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Migration(tgid=13) ⓘ

MMP13↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 3,   NLRP3↓, 1,   PGE2↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   PSD95↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose↝, 1,   eff↑, 1,   GSTA1↑, 14,   Half-Life↝, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BUN↓, 1,   creat↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   antiM↑, 1,   antiPy↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   Mood↑, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiP↑, 1,   Bacteria↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 62

Scientific Paper Hit Count for: GSTA1, Glutathione S-Transferase A1
3 Thymoquinone
2 Luteolin
2 Sulforaphane (mainly Broccoli)
1 Silver-NanoParticles
1 buckwheat sprouts
1 Caffeic acid
1 EGCG (Epigallocatechin Gallate)
1 L-Theanine
1 doxorubicin
1 Marjoram (Origanum majorana)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1091  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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