Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
Source:
Type:
For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
5457- AF,    Clinical pharmacokinetics of oral and injectable gold compounds
- Human, Nor, NA
*BioAv↝, *Dose↝, *Half-Life↑, *BioAv↝, *other↝,
3502- Bor,    Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates
- Review, CardioV, NA
*Half-Life↑, *VitD↑, *cardioP↑, *RenoP↓,
3503- Bor,    Chemical disposition of boron in animals and humans
- Review, Nor, NA
*Half-Life↑, *other↑,
6093- CHOC,    The relevance of theobromine for the beneficial effects of cocoa consumption
- Review, Nor, NA - NA, Asthma, NA
*toxicity↓, *eff↑, *Half-Life↑, *antiAll↑, *Inflam↓, *HDL↑, *Obesity↓,
6198- Cuc,    Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↑,
6670- Deg,    Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
- in-vivo, Nor, NA
*Half-Life↑, *BioAv↝,
7222- EGb 761,    Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use
- Review, AD, NA
*cognitive↑, *toxicity↓, *Dose↝, *BioAv↑, *Half-Life↑, *neuroP↑, *Half-Life↝, *Dose↝, *other↝, *eff↑,
7062- GamB,  Chit,    Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery
- in-vivo, Nor, NA
*Half-Life↑, *toxicity↓,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE/β-secretase↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
1710- Lyco,    Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
- Review, CardioV, NA
antiOx↓, ROS↓, BP↓, LDL↓, *toxicity∅, eff↑, ROS↑, *Half-Life↑, *BioAv↓, *BioAv↑, *antiOx↑,
8512- MAG,    Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation
- in-vivo, Nor, NA
*other↝, *toxicity↓, *Half-Life↑, *BioAv↑,
8901- MOR,    Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex
- in-vivo, Nor, NA
*BioAv↑, *Dose↝, *eff↑, *BioAv↑, *Half-Life↑, *BioAv↑,
2052- PB,    Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications
- Review, Nor, NA
*HDAC↓, *Half-Life↑, *Half-Life↑, *lipoGen↓, *ER Stress↓, *FAO↑, *ROS↓, *BioAv↑,
2966- PL,    A strategy to improve the solubility and bioavailability of the insoluble drug piperlongumine through albumin nanoparticles
- in-vitro, LiverDam, NA
*Half-Life↑, *BioAv↑, eff↑, ROS↑,
3923- PTS,    Pterostilbene Supplement Benefits: Longevity Miracle or Hoax
- Review, AD, NA
*BioAv↑, *Half-Life↑, *BBB↑, *BP↓, *cognitive↑,
3925- PTS,    Analysis of Safety from a Human Clinical Trial with Pterostilbene
- Trial, Nor, NA
*toxicity↓, *Half-Life↑, *BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, Synergy↑, Synergy↑, Synergy↑, Synergy↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3334- QC,    Pharmacokinetics of Quercetin Absorption from Apples and Onions in Healthy Humans
- Trial, Nor, NA
*Half-Life↑,
3019- RosA,    Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
- in-vivo, Nor, NA
*BioAv↝, *Half-Life↝, *Half-Life↑, *Half-Life↝, *BioAv↑,
7376- RS,    RENESE-R- polythiazide and reserpine tablet
- Review, Nor, NA
*BP↓, *BioAv↑, *Half-Life↑, *BBB↑, *diuretic↑, *toxicity↝,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *BioAv↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑, *chemoP↑,
4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, *Half-Life↑, *antiOx↑, *BioAv↑, *neuroP↑, *Inflam↑, *LDL↓, *cognitive↑,

Showing Research Papers: 1 to 27 of 27

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↓, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NQO1↓, 1,   NRF2↓, 1,   ROS↓, 2,   ROS↑, 2,   SOD?, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   MDM2↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   MAPK↑, 1,   mTOR↓, 1,   P70S6K↓, 1,   PKCδ↓, 1,   RAS↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   cMyc↓, 1,   FOXO1↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

KRAS↓, 1,   MMPs↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↝, 1,   eff↑, 4,   P-gp/ABCB1↓, 1,   selectivity↑, 1,   Synergy↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   KRAS↓, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 6,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 5,   GSR↑, 1,   GSTs↓, 1,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 2,   lipid-P↓, 2,   MDA↓, 2,   MPO↓, 1,   Nrf1↑, 1,   NRF2↑, 3,   ROS↓, 7,   SOD↑, 4,   TAC↑, 1,   VitC↑, 3,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh↝, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↓, 1,   ALAT↓, 1,   FAO↑, 1,   GSK‐3β↓, 1,   H2S↑, 1,   LDL↓, 2,   lipoGen↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   MAPK↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↓, 1,   OCT4↓, 1,   other↑, 2,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↓, 1,   PARK2↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

Cartilage↑, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   OATPs↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IFN-γ↓, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 5,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 9,   Inflam↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 5,   VitD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BDNF↑, 2,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 16,   BioAv↝, 5,   CYP2D6↓, 1,   Dose↝, 6,   eff↓, 3,   eff↑, 3,   eff↝, 1,   Half-Life↑, 28,   Half-Life↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BP↓, 3,   CRP↓, 1,   IL6↓, 3,   VitD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   antiCG↑, 1,   AntiDiabetic↑, 1,   BOLD↑, 1,   cardioP↑, 6,   chemoP↑, 1,   cognitive↑, 5,   diuretic↑, 1,   hepatoP↑, 3,   memory↑, 3,   neuroP↑, 9,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   RenoP↓, 1,   RenoP↑, 1,   Risk↓, 3,   Risk↑, 1,   Strength↑, 1,   toxicity↓, 7,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Diar↓, 1,   GutMicro↑, 2,  
Total Targets: 119

Scientific Paper Hit Count for: Half-Life, Half-Life
2 Boron
2 Lycopene
2 Pterostilbene
2 Quercetin
1 Anthocyanins
1 Auranofin
1 Chocolate
1 Cucurbitacin
1 Deguelin
1 Ginkgo biloba-EGb 761
1 Gambogic Acid
1 chitosan
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 isoquercitrin
1 Magnolol
1 Morin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 Silymarin (Milk Thistle) silibinin
1 Urolithin
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1109  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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