BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, Synergy↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
3537- 5-HTP,    5-Hydroxytryptophan: a clinically-effective serotonin precursor
- Review, Nor, NA
*5HT↑, *BioAv↑, *BBB↑,
3538- 5-HTP,    Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression
- in-vivo, Nor, NA
*GutMicro↑, *BBB↑, *5HT↑, *Weight↓,
5288- 5-HTP,    The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
- Trial, AD, NA
*5HT↑, *cognitive↑, *BBB↑, *Mood↑,
5312- acet,    Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action
- Review, Nor, NA
*COX1↓, *other?, *BBB↑, TRPV1↑,
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE/β-secretase↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
4549- AgNPs,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
4368- AgNPs,    Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro
- in-vitro, Nor, NA
*BBB↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
3444- ALA,    Alpha-Lipoic Acid Nootropic Review: Benefits, Use, Dosage & Side Effects
- Review, Nor, NA
*BBB↑, *cognitive↑, *neuroP↑, *antiOx↑,
3542- ALA,    Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
- Review, Var, NA
*antiOx↑, *VitE↑, *VitC↑, *GSH↑, *IronCh↑, *BioAv↑, *BBB↑,
3546- ALA,    Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study
- Study, AD, NA
*antiOx↑, *ROS↓, *cognitive∅, *lipid-P↓, *memory↑, *ChAT↑, *Acetyl-CoA↑, *Aβ↓, *BioAv↑, *BBB↑, *toxicity∅,
3548- ALA,    How Alpha Linolenic Acid May Sustain Blood–Brain Barrier Integrity and Boost Brain Resilience against Alzheimer’s Disease
- Review, AD, NA
*BBB↑, *other↑, *other↑, *DHA↑, *neuroP↑, *ROS↓, *other?,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2/PTGS2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
3550- ALA,    Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
- Review, AD, NA
*antiOx↑, *Inflam↓, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *BioAv↓, *Ach↑, *ROS↓, *cognitive↑, *neuroP↑, *BBB↑, *Half-Life↓, *BioAv↑, *Casp3↓, *Casp9↓, *ChAT↑, *cognitive↑, *eff↑, *cAMP↑, *IL2↓, *INF-γ↓, *TNF-α↓, *SIRT1↑, *SOD↑, *GPx↑, *MDA↓, *NRF2↑,
3544- ALA,    Alpha lipoic acid for dementia
- Review, AD, NA
*antiOx↑, *BBB↑, *VitC↑, *VitE↑, *GSH↑, *IronCh↑, *neuroP↑, *NO↓, *cognitive↑, *AntiAge↑, *memory↑, *ROS↓,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
3887- Api,    The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Aβ↓, *memory↑, *AChE↓, *Ach↑, *Dose↑, *BDNF↑, *TrkB↑, *p‑CREB↑, *BBB↑, *Ca+2?,
4280- Api,    Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms
- Review, AD, NA - Review, Park, NA
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2/PTGS2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
4279- Api,    The Beneficial Role of Apigenin against Cognitive and Neurobehavioural Dysfunction: A Systematic Review of Preclinical Investigations
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *5HT↑, *CREB↑, *BDNF↑, *memory↑, *motorD↑, *Mood↑, *cognitive↑, *ROS↓,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5425- ASTX,    Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↑, *AChE↓, *BACE/β-secretase↓, *MAOA↓, *Aβ↓, *memory↑, *MDA↓, *SOD↑, *NRF2↑, *HO-1↑, *NF-kB↓, *GSK‐3β↓, *ChAT↑, *iNOS↓, *ROS↓, *BBB↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
3678- BBR,    Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
- Review, AD, NA
*APP↓, *PPARγ↑, *NF-kB↓, *Aβ↓, *cognitive↑, *antiOx↑, *Inflam↓, *Apoptosis↓, *BioAv↑, *BioAv↝, *BBB↑, *motorD↑, *NRF2↑, *HO-1↑, *ROS↓, *p‑Akt↑, *p‑ERK↑,
3680- BBR,    Network pharmacology reveals that Berberine may function against Alzheimer’s disease via the AKT signaling pathway
- in-vivo, AD, NA
*Akt↑, *neuroP↑, *p‑ERK↑, *Aβ↓, *Inflam↓, *ROS↓, *BioAv↑, *BBB↑, *Half-Life↝, *memory↑, *cognitive↑, *HSP90↑, *APP↓, *mTOR↓, *P70S6K↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *Apoptosis↓,
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5561- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *cognitive↑, *BBB↑, *lipid-P↓, *eff↑,
5563- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease
- Review, AD, NA
*BBB↑, *lipid-P↓, *eff↑, *cognitive↑,
3697- BM,    Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies
- Review, AD, NA
*ROS↓, *cognitive↑, *memory↑, *BBB↑, *P-gp/ABCB1↓, *CYP3A2↓,
5649- BNL,    Borneol, a novel agent that improves central nervous system drug delivery by enhancing blood–brain barrier permeability
- Review, Nor, NA
*BBB↑, *other↑, *P-gp/ABCB1↓, *toxicity⇅, *BioAv⇅, *Dose↑, *ABC↓, *MRP1/ABCC1↓, *5HT↑, *GABA↑, *Synergy↑,
5665- BNL,    Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies
- in-vivo, Nor, NA
*BBB↑, eff↑,
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp/ABCB1↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp/ABCB1↓, *CYP3A4↓, *ROS↓, *neuroP↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
7832- CA,  CGA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *cognitive↑, *memory↑, *ROS↓, *p‑tau↓, *GSK‐3β↓, *MAPK↓, *NeuroI↓, *P53↓, *Casp3↓, *AChE↓, *APP↓, *BACE/β-secretase↓, *neuroP↑, *Dose↝,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5864- CA,    Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- vitro+vivo, Stroke, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,
5908- CAR,    Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI
- in-vivo, Nor, NA
*TRPM7↓, *BBB↑, *motorD↑, *cognitive↑, *Dose↝, MMPs↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2/PTGS2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑, *CompStab↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
6045- CGA,  SeNPs,    A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice
- in-vivo, AD, NA
*neuroP↑, *BioAv↑, *GutMicro↑, *BBB↑, *Aβ↓, *glucose↝,

Showing Research Papers: 1 to 50 of 170
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 170

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   antiOx⇅, 1,   Catalase↓, 1,   GPx↑, 1,   GSH↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↝, 1,   lipid-P↑, 2,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 12,   ROS⇅, 2,   SOD↓, 1,   Trx1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   OCR↑, 1,   OXPHOS↑, 1,   mt-OXPHOS↑, 1,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   AMPK↑, 2,   ATP↓, 1,   ECAR↓, 1,   GlutMet↓, 1,   GSK‐3β↑, 1,   lactateProd↓, 1,   NADPH↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 8,   BAD↑, 1,   Bak↓, 1,   Bak↑, 2,   BAX↑, 5,   Bcl-2↓, 6,   Bcl-xL↓, 3,   BID↑, 1,   BNIP3↑, 1,   Casp↑, 1,   Casp12↑, 1,   Casp3↑, 9,   Casp6↑, 1,   Casp8↑, 2,   Casp9↑, 7,   proCasp9↓, 1,   cFLIP↓, 1,   Cyt‑c↑, 8,   DR5↑, 3,   Fas↑, 2,   Ferroptosis↑, 1,   Mcl-1↑, 1,   MDM2↓, 1,   p38↑, 1,   p‑p38↓, 1,   survivin↓, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 7,   p‑Akt↓, 2,   EF-1α↓, 1,   EGFR↑, 1,   p‑EGFR↓, 1,   ERK↓, 1,   p‑ERK↓, 2,   HER2/EBBR2↓, 1,   HGF/c-Met↓, 1,   IKKα↓, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   mTOR↓, 1,   PI3K↓, 4,   PTEN↑, 4,   c-Raf↓, 1,   RAS↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   cMyc↓, 1,   DNMTs↓, 2,   FOXM1↓, 1,   FOXO3↓, 1,   H3↓, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   OCT4↓, 1,   other↑, 1,   other↝, 1,   SOX2↓, 1,   SOX4↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNArepair↓, 1,   hTERT/TERT↓, 1,   P53↑, 6,   P53↝, 1,   PARP↑, 2,   cl‑PARP↑, 3,   PARP1↑, 1,   PCNA↓, 1,   Telomerase↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 4,   CDK4↓, 2,   CDK6↓, 1,   CHK1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   P21?, 1,   P21↑, 2,   p27/CDKN1B↑, 1,   p‑RB1↓, 1,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMPs↑, 1,   CD133↓, 1,   CSCs↓, 1,   FGF↓, 1,   IGF-1↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   TumCG↓, 3,   TumCP↓, 5,   TumCP↑, 1,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   EMT↓, 3,   FAK↓, 1,   p‑FAK↓, 1,   fascin↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 5,   N-cadherin↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumMeta↓, 3,   TumMeta↑, 1,   Twist↓, 2,   uPA↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   HIF-1↓, 1,   Hif1a↓, 6,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 3,   MMP↓, 5,   TRPV1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   COX2/PTGS2↓, 2,   IL1↓, 1,   IL1β↓, 3,   IL6↓, 2,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 4,   NF-kB↓, 8,   NF-kB↑, 1,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↝, 1,   ChemoSen↑, 12,   DDS↑, 1,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 13,   eff↝, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 3,   RadioS↑, 2,   selectivity↑, 5,   Synergy↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

CEA↓, 1,   EGFR↑, 1,   p‑EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   NOS2↑, 1,   TF-Ag↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 5,   cognitive?, 1,   cognitive↑, 2,   neuroP↑, 1,   OS↑, 2,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 1,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↓, 1,   GutMicro↑, 1,  
Total Targets: 232

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↓, 1,   NA↝, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 1,   antiOx↑, 71,   mt-antiOx↑, 1,   ARE↑, 2,   Catalase↓, 1,   Catalase↑, 19,   Copper↓, 1,   CoQ10↑, 1,   Fenton↓, 2,   GPx↑, 15,   GPx4↑, 2,   GSH↑, 39,   GSR↓, 1,   GSR↑, 9,   GSTs↓, 3,   GSTs↑, 5,   H2O2↓, 1,   H2O2∅, 1,   HDL↑, 1,   HO-1↑, 21,   HO-2↓, 1,   hyperG↓, 1,   Iron↓, 3,   Keap1↓, 2,   Keap1↑, 2,   lipid-P↓, 25,   MDA↓, 14,   MDA↑, 3,   MPO↓, 4,   NQO1↑, 5,   NQO1↝, 1,   NRF2↑, 43,   RNS↓, 4,   ROS?, 1,   ROS↓, 99,   SOD↓, 1,   SOD↑, 37,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 4,   Thiols↑, 1,   Trx↑, 1,   Trx1↑, 1,   TrxR↑, 1,   TrxR1↑, 1,   uricA↓, 1,   VitC↑, 3,   VitE↑, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FPN↑, 1,   IronCh↑, 16,   TfR1/CD71↓, 2,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   compIV↑, 3,   compV↑, 1,   ETC↑, 3,   FIS1↓, 1,   mitResp↑, 1,   mtDam↓, 1,   OCR↑, 4,   PDH↑, 1,   PGC-1α↑, 4,   SIRT3↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 2,   5LO↓, 2,   ACC↑, 1,   Acetyl-CoA↑, 1,   ACSL4↓, 1,   adiP↑, 1,   ALAT↓, 2,   AMPK↑, 7,   p‑AMPK↑, 1,   ATP↑, 8,   cAMP↑, 2,   DHA↑, 1,   ECAR↓, 1,   FAO↓, 1,   G6PD↑, 1,   glucose↓, 1,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↑, 5,   Glycolysis↓, 1,   GSK‐3β↓, 13,   p‑GSK‐3β↑, 2,   H2S↑, 1,   LDL↓, 4,   NADPH↓, 1,   NADPH↑, 2,   PDK1 / PDPK1↓, 1,   PDKs↓, 1,   SIRT1↓, 1,   SIRT1↑, 6,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 8,   BAX↓, 3,   BAX↑, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 2,   Bcl-2↑, 2,   Casp↓, 1,   Casp3↓, 11,   Casp3↑, 1,   Casp6↓, 1,   Casp9↓, 4,   Casp9↑, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 1,   Ferroptosis↓, 4,   iNOS↓, 16,   p38↑, 1,   p‑p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 10,   p‑Akt↑, 2,   AKT1↓, 1,   CREB↑, 3,   p‑CREB↑, 3,   ERK↓, 2,   ERK↑, 3,   p‑ERK↑, 2,   IGF-1R↓, 1,   JAK↓, 1,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 8,   MAPK↑, 3,   mTOR↓, 5,   mTOR↑, 2,   p‑mTOR↓, 1,   P70S6K↓, 1,   PDGFR-BB↓, 1,   PI3K↓, 4,   PI3K↑, 7,   PKCδ?, 1,   PKCδ↑, 3,   PTEN↓, 3,   PTP1B↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   FOXO3↑, 1,   H3↑, 1,   H4↑, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   MEF2D↑, 1,   other?, 2,   other↓, 3,   other↑, 7,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 2,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↑, 1,   HSPs↑, 2,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

autophagy↓, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   CTSZ↓, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 1,   PARK2↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   DNArepair↑, 1,   P53↓, 2,   SIRT6↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cellSen↝, 1,   E2Fs↑, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Choline↑, 1,   Ki-67↑, 1,   neuroG↑, 6,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   AP-1↓, 3,   Ca+2?, 1,   Ca+2↓, 5,   Ca+2↝, 1,   Cartilage↑, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP9↓, 7,   MMPs↓, 1,   N-cadherin↑, 1,   NFAT↓, 1,   Rho↓, 1,   p‑T-cadherin↓, 1,   TG2/TGase↓, 1,   TGF-β1↑, 1,   TregCell↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   CD31/PECAM-1↑, 1,   eNOS↑, 1,   Hif1a↑, 1,   NO↓, 13,   NO↑, 1,   VCAM-1↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 171,   CellMemb↑, 1,   CLDN1↝, 1,   CLDN5↑, 1,   CX43/GJA1↑, 1,   GastroP↑, 2,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   memfluid↑, 1,   MMP↑, 10,   MUC19↓, 1,   MUC2↓, 1,   THBD↑, 1,   TRPM7↓, 2,   TRPV3↑, 1,   ZO-1↑, 1,   ZO-1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CD4+↑, 1,   CD8+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 23,   HMGB1↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL1↓, 1,   IL10↓, 1,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 26,   IL2↓, 3,   IL23↓, 1,   IL33↓, 1,   IL4↓, 3,   IL6↓, 22,   IL6↑, 2,   IL8↓, 4,   Imm↑, 3,   INF-γ↓, 2,   INF-γ↑, 1,   Inflam↓, 73,   Inflam↑, 2,   IRF3↓, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3↓, 1,   MyD88↓, 2,   NeuroI↓, 4,   NF-kB↓, 28,   NF-kB↑, 2,   p‑NF-kB↓, 3,   NLRP3↓, 11,   PGE2↓, 7,   RANTES↓, 2,   TLR2↓, 1,   TLR4↓, 5,   TNF-α↓, 35,   TRAF6↓, 1,   TRIF↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 8,   Ach↑, 9,   AChE↓, 32,   AChE↑, 1,   ADAM10↑, 2,   ADAM10↝, 1,   BChE↓, 6,   BDNF↑, 25,   BrainVol↑, 1,   CARTPT↑, 1,   ChAT↑, 7,   GABA↓, 1,   GABA↑, 3,   MAOA↓, 4,   MAOB↓, 1,   NGF↑, 2,   PSD95↑, 2,   SNAP25↑, 1,   TrkB↑, 3,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APOE4↓, 1,   APP↓, 8,   cl‑APP↑, 1,   Aβ↓, 67,   Aβ42↓, 3,   BACE/β-secretase↓, 16,   BACE/β-secretase↝, 1,   PSEN1/PS1↑, 1,   tau↓, 14,   p‑tau↓, 16,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,   PPARα↑, 1,   PPARγ↑, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABC↓, 1,   BioAv↓, 18,   BioAv↑, 39,   BioAv⇅, 1,   BioAv↝, 17,   BioAv∅, 1,   BioEnh↑, 4,   ChemoSen↑, 1,   CompStab↑, 1,   CYP3A2↓, 1,   CYP3A4↓, 1,   DDS↑, 2,   Dose↓, 1,   Dose↑, 2,   Dose↝, 29,   Dose∅, 1,   eff↓, 3,   eff↑, 28,   eff↝, 1,   Half-Life↓, 5,   Half-Life↑, 4,   Half-Life↝, 10,   Half-Life∅, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 6,   P450↓, 1,   selectivity↑, 1,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   anemia↓, 1,   AST↓, 2,   BG↓, 1,   BloodF↑, 3,   BP↓, 5,   BP↝, 1,   BP∅, 1,   creat↓, 2,   CRP↓, 1,   Ferritin↓, 1,   Ferritin↑, 1,   HemoG↑, 1,   IL6↓, 22,   IL6↑, 2,   LDH↓, 3,   NOS2↓, 1,   RBC↑, 1,   TC↓, 1,   TMAO↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 3,   AntiCan↑, 5,   AntiDiabetic↑, 2,   AntiMyl↑, 1,   AntiTum↑, 1,   Bone Healing↑, 1,   cardioP↑, 15,   cognitive↑, 77,   cognitive↝, 1,   cognitive∅, 2,   diuretic↑, 1,   hepatoP↓, 2,   hepatoP↑, 8,   Learn↑, 3,   memory↓, 1,   memory↑, 62,   memory∅, 1,   Mood↑, 5,   motorD↑, 13,   Mucositis↓, 1,   neuroP?, 1,   neuroP↑, 88,   NP/CIPN↓, 1,   Obesity↓, 2,   OS↑, 2,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 2,   Sleep↑, 3,   Strength↑, 4,   Stress↓, 2,   Stroke↓, 6,   toxicity↓, 12,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 2,   toxicity∅, 5,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 5,   AntiFungal↑, 4,   AntiViral↑, 3,   Bacteria↓, 6,   GutMicro↑, 14,   Sepsis↓, 3,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 1,  
Total Targets: 406

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
13 Alpha-Lipoic-Acid
13 Selenium NanoParticles
9 Curcumin
7 Hydrogen Gas
6 Methylene blue
6 Mushroom Lion’s Mane, Hericium erinaceus
5 borneol
5 Luteolin
5 Urolithin
4 Chlorogenic acid
4 Mung Bean Sprouts
4 EGCG (Epigallocatechin Gallate)
4 Honokiol
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 Berberine
3 Carvacrol
3 Ferulic acid
3 Licochalcone A
3 Lycopene
3 Resveratrol
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 Silver-NanoParticles
2 Baicalein
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Carnosic acid
2 Choline
2 Cinnamon
2 Isobavachalcone
2 Lactoferrin/Talactoferrin
2 Melatonin
2 Vitamin B3,Niacin
2 Pterostilbene
2 Quercetin
2 S-adenosyl-L-methionine
2 Thymoquinone
2 Turmerones
1 1,8-Cineole
1 acetaminophen
1 Anthocyanins
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 chitosan
1 Coenzyme Q10
1 Crocetin
1 Galantamine
1 Cysteamine
1 Deguelin
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Fisetin
1 Gold NanoParticles
1 Huperzine A/Huperzia serrata
1 Inositol
1 Isoliquiritigenin
1 isoflavones
1 isoquercitrin
1 Magnolol
1 Matrine
1 Isovitexin
1 Vitexin
1 MCT oil
1 Magnetic Fields
1 Moringa oleifera
1 Methylsulfonylmethane
1 L-Theanine
1 Myricetin
1 nicotinamide adenine dinucleotide
1 Protocatechuic acid
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 Metformin
1 Silymarin (Milk Thistle) silibinin
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1123  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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