hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
4395- AgNPs,    Hepatoprotective effect of silver nanoparticles synthesized using aqueous leaf extract of Rhizophora apiculata
- in-vivo, LiverDam, NA
*hepatoP↑, *LDH↓,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
9236- AITC,    Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte
- in-vivo, LiverDam, NA
*NRF2↑, *hepatoP↑, *HO-1↑,
5355- AL,    Mini-review: The health benefits and applications of allicin
- Review, Var, NA
*BioAv↑, *cardioP↑, *hepatoP↑, *RenoP↑, *Half-Life↝, *BioAv↓, *neuroP↑, *cognitive↑, *ROS↓, *lipid-P↓, *DNArepair↑, *ChemoSen↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
2667- AL,    Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment
- Review, GC, NA
AntiCan↑, ChemoSen↑, angioG↓, chemoP↑, *GutMicro↑, *antiOx↑, other↝, GSH↓, Thiols↓, *ROS↓, *hepatoP↑, *Inflam↓, *NF-kB↓,
6763- AL,    Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery
- Review, Nor, NA
*Inflam↓, *AntiBio↑, *AntiDiabetic↑, *hepatoP↑, *antiOx↑, *AntiFungal↑, *Wound Healing↑, *other↑, *BP↓, *LDL↓, *AntiAg↑, *cognitive↑, *memory↑, Risk↑, *COX1↓, *TXA2↓, *antiAll↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
7398- Amla,    Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis
- in-vivo, Nor, NA
*hepatoP↑,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7403- Amla,    Aqueous Extract of Emblica officinalis Linn (Indian gooseberry) in Combination with Iodine is More Efficacious than Iodine Alone in Mitigating Mucositis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: Retrospective Observations
- Trial, HNSCC, NA
Mucositis↓, Dose↝, Dose↝, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *hepatoP↑, *RenoP↑, *neuroP↑, Dose↝,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
7839- AO,  ISQ,    The Protective Effects of Acer okamotoanum and Isoquercitrin on Obesity and Amyloidosis in a Mouse Model
- in-vivo, AD, NA - in-vivo, Obesity, NA
*Dose↝, *Obesity↓, *Leptin↓, *adiP↑, *hepatoP↑, *PSEN1/PS1↓, *PSEN2/PS-2↓, *BACE/β-secretase↓, *Synergy↑,
2636- Api,    Apigenin unveiled: an encyclopedic review of its preclinical and clinical insights
- Review, Nor, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *Inflam↓, *antiOx↑, *hepatoP↑, ChemoSen↑,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1/CCL2↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
3170- Ash,    Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
- in-vitro, Nor, NRK52E - in-vivo, NA, NA
*RenoP↑, *hepatoP↑, *creat↓, *BUN↓, *uricA↓, *Apoptosis↓, *α-SMA↓,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
4814- ASTX,    Chemopreventive and therapeutic efficacy of astaxanthin against cancer: A comprehensive review
- Review, Var, NA
Apoptosis↑, EMT↓, AntiCan↑, *cardioP↑, *neuroP↑, TumCG↓, *antiOx↑, *Bacteria↓, *Imm↑, *hepatoP↑, *AntiDiabetic↑, ROS↓, *chemoPv↑,
5506- Ba,    Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System
- in-vivo, Nor, NA
*AST↓, *ALAT↓, *GSH↓, *SOD↓, *MDA↓, *hepatoP↑, *Inflam↓, BioAv↑,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
2610- Ba,    Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice
- in-vivo, Nor, NA
*TNF-α↑, *IL6↑, *hepatoP↑,
2609- Ba,    Baicalein: unveiling the multifaceted marvel of hepatoprotection and beyond
- Review, Nor, NA
*hepatoP↑, *neuroP↑, *Inflam↓,
2607- Ba,  SIL,    Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2
- in-vivo, Nor, NA
*BioEnh↑, *hepatoP↑, *antiOx↑, *Inflam↓,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2614- Ba,    Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders
- Review, Nor, NA
*toxicity↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *MCP1/CCL2↓, *hepatoP↑, *neuroP↑, *antiAll↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2675- BBR,    The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress
- Review, Var, NA
*Inflam↓, *antiOx↑, *ER Stress↓, *cardioP↑, *RenoP↑, *hepatoP↑,
2677- BBR,    Liposome-Encapsulated Berberine Alleviates Liver Injury in Type 2 Diabetes via Promoting AMPK/mTOR-Mediated Autophagy and Reducing ER Stress: Morphometric and Immunohistochemical Scoring
- in-vivo, Diabetic, NA
*hepatoP↑, *LC3II↑, *Beclin-1/ATG6↑, *AMPK↑, *mTOR↑, *ER Stress↓, *CHOP/DDIT3↓, *JNK↓, *ROS↓, *Inflam↓, *BG↓, *SOD↑, *GPx↑, *Catalase↑, *IL10↑, *IL6↓, *TNF-α↓, *ALAT↓, *AST↓, *ALP↓,
4275- BBR,    Pharmacological effects of berberine on mood disorders
- Review, AD, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *eff↑, *5HT↑, *Mood↑, *BDNF↑,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, Synergy↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
2718- BetA,    The anti-cancer effect of betulinic acid in u937 human leukemia cells is mediated through ROS-dependent cell cycle arrest and apoptosis
- in-vitro, AML, U937
TumCCA↑, Apoptosis↑, i-ROS↑, cycA1/CCNA1↓, CycB/CCNB1↓, P21↑, Cyt‑c↑, MMP↓, Bax:Bcl2↑, Casp9↑, Casp3↑, PARP↓, eff↓, *antiOx↑, *Inflam↓, *hepatoP↑, selectivity↑, NF-kB↓, *ROS↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,
5474- BM,    Pharmacological attributes of Bacopa monnieri extract: Current updates and clinical manifestation
- Review, Var, NA
*memory↑, *neuroP↑, *cognitive↑, *hepatoP↑, *antiOx↑, *AntiDiabetic↑, *fatigue↓, *GSK‐3β↓, *PI3K↑, *Akt↑, *tau↓, *ROS↓, *Inflam↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
3520- Bor,    Effect of boron element on photoaging in rats
- in-vivo, Nor, NA
*hepatoP↑, *BMD↑, *COX2/PTGS2↓, *IL8↓, *NF-kB↓, *IL6↓, *TNF-α↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2/KDR/Flk1↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2/PTGS2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓, *AntiArt↑, *AntiDiabetic↑, *antiAll↑,
6556- BSB,    A Comprehensive Study of Therapeutic Applications of Chamomile
- Review, Nor, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *hepatoP↑, *AntiCan↑, *other↝, *toxicity↓, *Wound Healing↓, *Dose↝, *Dose↝, *eff↝, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *AST↓, *ALAT↓, *antiAll↑,
7953- BuckWS,  RT,    Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid
- Review, Nor, NA
*GastroP↑, *hepatoP↑, *AntiDiabetic↑, *Inflam↓, *BioAv↓, *LDL↓, *Fenton↓, *AGEs↓, *GSH↑, *Dose↝,
7947- BuckWS,    Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice
- vitro+vivo, Colon, NA
Inflam↓, *hepatoP↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,

Showing Research Papers: 1 to 50 of 264
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 264

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 3,   Catalase↑, 2,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 7,   GSH↑, 3,   HO-1↓, 1,   HO-1↑, 6,   Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 2,   NOX↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 5,   ROS↓, 12,   ROS↑, 46,   ROS⇅, 2,   ROS↝, 2,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   CDC25↓, 2,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   ETC↓, 1,   mitResp↓, 1,   mtDam↑, 6,   PGC-1α↑, 1,   SDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 9,   AMPK↑, 4,   ATP↓, 7,   ATP↑, 1,   mt-ATP↓, 1,   glucose↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 10,   GSK‐3β↓, 2,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HK2↓, 6,   lactateProd↓, 5,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PKM2↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   TCA↓, 2,   TumCM/A↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

AIF↑, 1,   Apoptosis?, 1,   Apoptosis↓, 2,   Apoptosis↑, 45,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 2,   Bak↑, 2,   BAX↓, 1,   BAX↑, 26,   Bax:Bcl2↑, 7,   Bcl-2↓, 23,   Bcl-2↑, 2,   Bcl-xL↓, 2,   BIM↑, 2,   BNIP3↑, 1,   Casp↑, 5,   Casp1↑, 1,   Casp12↑, 1,   Casp3↑, 32,   cl‑Casp3↑, 3,   Casp7↑, 5,   cl‑Casp7↑, 1,   Casp8↑, 14,   Casp9↑, 21,   cl‑Casp9↑, 2,   CellShr↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 19,   DR5↑, 4,   FADD↑, 1,   Fas?, 1,   Fas↑, 5,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 2,   iNOS↓, 3,   Mcl-1↓, 4,   MDM2↓, 2,   MDM2↑, 1,   MOMP↑, 2,   p38↓, 1,   p38↑, 5,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 7,   TNFR 1↑, 1,   TumCD↑, 2,   XIAP↓, 8,   XIAP↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 37,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 6,   CIP2A↓, 1,   CK2↓, 1,   cMET↓, 3,   p‑cMET↑, 1,   CREB↓, 1,   EGFR↓, 8,   ERK↓, 15,   ERK↑, 2,   p‑ERK↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   IGF-1R↓, 1,   IKKα↓, 1,   JAK1↓, 1,   JAK2↓, 3,   JAK3↓, 1,   JNK↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   LIMK1↓, 1,   MAPK↓, 8,   MAPK↑, 4,   MEK↓, 2,   mTOR↓, 21,   p‑mTOR↓, 1,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 31,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 1,   PIK3CA↓, 1,   PKA↓, 1,   PKCδ↓, 1,   PTEN↓, 1,   PTEN↑, 5,   RAS↓, 1,   RAS↑, 1,   RET↓, 1,   SHP1↑, 1,   Sp1/3/4↓, 4,   STAT3↓, 24,   STAT3↑, 2,   p‑STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF2↓, 1,   ATF4↑, 2,   cJun↓, 1,   cMyc↓, 14,   DNMT1↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXO1↓, 1,   FOXO1↑, 1,   p‑FOXO3↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC8↓, 1,   miR-124-3p↓, 1,   miR-34a↓, 2,   miR-34a↑, 1,   MYCN↓, 1,   OCT4↓, 3,   other↑, 1,   other↝, 1,   SOX2↓, 4,   tumCV?, 1,   tumCV↓, 12,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↓, 1,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   GRP78/BiP↝, 1,   HSP90↓, 2,   NQO2↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 5,   LC3II↑, 2,   p62↓, 1,   TumAuto↑, 11,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 10,   hTERT/TERT↓, 2,   P53↓, 2,   P53↑, 15,   p‑P53↑, 1,   PARP↓, 1,   PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 5,   cl‑PARP1↑, 1,   PCNA↓, 7,   TOP1↓, 2,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 2,   CDK2↓, 7,   CDK4↓, 8,   CDK4↑, 1,   CDK6↓, 2,   CDK6↑, 1,   CDK8↓, 1,   CHK1↓, 1,   Chk2↑, 1,   ChrCon↑, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 9,   cycD1/CCND1↓, 14,   cycE/CCNE↓, 2,   cycE/CCNE↑, 1,   Ki-67↓, 7,   mitA↑, 1,   P21↑, 13,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   pRB↓, 1,   RB1↓, 1,   TumCCA?, 1,   TumCCA↑, 46,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   cFos↓, 3,   CSCs?, 1,   CSCs↓, 6,   Diff↑, 1,   Gli1↓, 1,   IGF-1↓, 1,   Ki-67↓, 7,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 5,   NOTCH↑, 1,   NOTCH1↓, 2,   NOTCH1↑, 3,   Shh↓, 2,   Smo↓, 1,   STAT1↓, 1,   TumCG↓, 20,   TumCP↓, 34,   Wnt↓, 10,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 4,   BACH1↓, 1,   Ca+2↑, 3,   i-Ca+2↑, 1,   COL1↓, 2,   E-cadherin↓, 4,   E-cadherin↑, 7,   EMT↓, 19,   EMT↝, 1,   FAK↓, 2,   FAK↑, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   LAMs↓, 1,   LRP1↓, 1,   MALAT1↓, 1,   MMP1↓, 1,   MMP2↓, 20,   MMP7↓, 1,   MMP9↓, 22,   MMP9↑, 2,   MMPs↓, 9,   MTA1↓, 1,   N-cadherin↓, 3,   PDGF↓, 2,   Rho↓, 1,   Rho↝, 1,   ROCK1↓, 1,   Slug↓, 3,   Smad1↑, 1,   SMAD4↓, 1,   Snail↓, 3,   TET1↑, 2,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↓, 2,   TIMP2↑, 2,   TRIB3↑, 1,   TumCI↓, 16,   TumCMig↓, 20,   TumMeta↓, 17,   TumMeta↑, 2,   Twist↓, 6,   uPA↓, 4,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 12,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 22,   angioG↑, 1,   HIF-1↓, 2,   HIF-1↑, 1,   Hif1a↓, 13,   Hif1a↝, 1,   VCAM-1↓, 1,   VEGF↓, 24,   VEGFR1↓, 1,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 3,   MMP↓, 18,   TRPM7↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   CD47↓, 1,   CD59↑, 1,   CD8+↑, 2,   COX1↓, 1,   COX2/PTGS2↓, 17,   CXCc↓, 1,   CXCR4↓, 2,   HMGB1↓, 1,   ICAM-1↓, 3,   IFN-γ↓, 1,   IL1↑, 1,   IL17↓, 1,   IL1β↓, 7,   IL1β↑, 1,   IL2↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 12,   IL8↓, 3,   Imm↑, 4,   Imm↝, 1,   INF-γ↝, 1,   Inflam↓, 12,   Inflam↝, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 3,   Neut↑, 1,   NF-kB↓, 32,   NF-kB↑, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   NLRP3↓, 1,   NLRP3↑, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 6,   T-Cell↑, 1,   Th1 response↑, 1,   Th17↑, 1,   TLR4↓, 1,   TNF-α↓, 10,   TNF-α↑, 3,   TRADD↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 7,   BioAv↑, 7,   BioAv↝, 4,   BioEnh?, 1,   CBR1↓, 1,   ChemoSen↑, 43,   CompStab↓, 1,   CompStab↑, 1,   CompStab↝, 1,   CYP1A1↑, 1,   Dose?, 1,   Dose↝, 14,   eff↓, 1,   eff↑, 13,   eff↝, 4,   eff∅, 1,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   NAT↓, 1,   P-gp/ABCB1↓, 5,   P-gp/ABCB1↑, 1,   RadioS↑, 9,   selectivity↑, 9,   selectivity∅, 1,   Synergy?, 1,   Synergy↑, 27,  

Clinical Biomarkers(tgid=22) ⓘ

AFP?, 1,   ALAT↓, 9,   ALP↓, 1,   AR↓, 4,   AST↓, 5,   BP↓, 1,   BRCA1↓, 1,   BUN↓, 1,   creat↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 8,   EZH2↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 12,   LDH↓, 1,   PC↑, 1,   PD-L1↓, 3,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 24,   AntiTum↑, 6,   cardioP↑, 4,   chemoP↑, 16,   chemoPv↑, 5,   cognitive↑, 1,   Mucositis↓, 2,   NP/CIPN↓, 2,   OS↓, 1,   OS↑, 2,   Pain↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 5,   RenoP↑, 4,   Risk↓, 4,   Risk↑, 1,   toxicity↓, 4,   toxicity↝, 2,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 8,  
Total Targets: 460

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 7,   antiOx↑, 128,   ARE↑, 4,   Bil↓, 4,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 56,   DPPH↓, 1,   Fenton↓, 4,   GCLC↑, 2,   GCLC↝, 1,   GCLM↑, 2,   GCLM↝, 1,   GPx↑, 42,   GPx1↑, 1,   GPx4↑, 1,   GSH↓, 1,   GSH↑, 77,   GSH/GSSG↑, 2,   GSR↑, 5,   GSSG↓, 1,   GSTs↓, 1,   GSTs↑, 12,   H2O2↓, 2,   HDL↓, 2,   HDL↑, 4,   HDL∅, 1,   HO-1?, 1,   HO-1↓, 2,   HO-1↑, 37,   HO-1⇅, 1,   hyperG↓, 2,   Keap1↓, 6,   Keap1↝, 2,   lipid-P?, 1,   lipid-P↓, 59,   MDA↓, 60,   MDA↑, 1,   MPO↓, 12,   NQO1↑, 11,   NQO1↝, 2,   NRF2?, 1,   NRF2↓, 2,   NRF2↑, 68,   ROS?, 2,   ROS↓, 160,   ROS↑, 4,   ROS⇅, 2,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 80,   SOD1↑, 3,   SOD2↑, 1,   TAC↑, 4,   TBARS↓, 3,   Thiols↑, 1,   TOS↓, 1,   TOS↑, 1,   Trx↑, 2,   Trx1↑, 1,   uricA↓, 2,   VitC↑, 2,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compII↑, 1,   compIII↑, 1,   DRP1/DNM1L↓, 1,   Insulin↓, 2,   Insulin↑, 1,   MFN2↑, 1,   mtDam↓, 5,   PDH↑, 1,   PGC-1α↑, 5,   PGC-1α↝, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   15-LOX/ALOX15↓, 1,   5LO↓, 3,   5LO↝, 1,   ACADS/SCAD↑, 1,   ACC↓, 2,   ACC↑, 1,   adiP↑, 1,   ALAT↓, 73,   ALAT↑, 1,   AMPK↓, 1,   AMPK↑, 18,   p‑AMPK↑, 2,   ATP↓, 1,   ATP↑, 6,   cAMP↑, 2,   CPT1A↑, 2,   CRM↑, 3,   FABP4↓, 1,   FAM↑, 1,   FASN↓, 2,   FFA/NEFA↓, 1,   glucose↓, 9,   glucose↝, 2,   GlucoseCon↓, 1,   GlucoseCon↑, 2,   glyC↓, 1,   Glycolysis↓, 1,   GSK‐3β↓, 6,   GSK‐3β↑, 2,   p‑GSK‐3β↑, 1,   H2S↑, 2,   HK2↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDL↓, 15,   lipidLev↓, 5,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 4,   NADPH↑, 2,   NH3↓, 1,   PDKs↓, 1,   PFKP↓, 1,   PKM2↓, 2,   PLA2↓, 1,   SCD1↓, 1,   SIRT1↑, 12,   SIRT1↝, 1,   SIRT2↑, 1,   SREBF2⇅, 1,   SREBP1/SREBF1↓, 4,   SREBP1/SREBF1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   Apoptosis↓, 18,   ASC↓, 1,   BAX↓, 12,   Bax:Bcl2↓, 2,   Bcl-2↓, 2,   Bcl-2↑, 7,   Casp↓, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 22,   cl‑Casp3↓, 3,   proCasp3↓, 1,   Casp8↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 8,   Cyt‑c↓, 5,   Fas↓, 4,   Ferroptosis↓, 2,   GranB/GZMB↓, 1,   iNOS↓, 18,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 5,   p‑p38↓, 1,   Pyro↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   Akt↑, 9,   p‑Akt↑, 1,   Akt2↓, 1,   AMPKα↑, 1,   CREB↑, 1,   ERK↓, 2,   p‑ERK↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 3,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK↓, 1,   JAK2↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 6,   JNK↑, 1,   p‑JNK↓, 2,   MAPK↓, 10,   MAPK↑, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   mTOR↓, 3,   mTOR↑, 4,   p‑mTOR↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 5,   PI3K↑, 5,   PKCδ↓, 1,   PP2A↑, 1,   STAT↓, 2,   STAT3↓, 4,   STAT3↑, 1,   p‑STAT3↓, 1,   STAT5↓, 1,   STK11/LKB1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 8,   ATF2↑, 1,   ATF4↓, 3,   cJun↓, 1,   p‑cJun↓, 1,   cMyc↓, 1,   DNMT1↓, 1,   FOXO3↑, 1,   HDAC↑, 1,   miR-23a-3p↓, 1,   miR-34a↓, 1,   OCT4↓, 1,   other↓, 1,   other↑, 6,   other↝, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 5,   CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 8,   GRP78/BiP↓, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   HSPs↑, 1,   XBP-1↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   autophagy↑, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↓, 1,   LC3II↑, 2,   LC3s↓, 1,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 11,   DNArepair↑, 1,   P53↓, 2,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   Telomerase↓, 2,   TOP1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   GH↑, 1,   HH↓, 1,   IGF-1↓, 1,   Ki-67↓, 1,   neuroG↑, 2,   TumCP↓, 2,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   AntiAg↑, 12,   AP-1↓, 3,   BACH1↓, 1,   Ca+2↓, 7,   Ca+2↑, 1,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↓, 4,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 2,   EMT↓, 3,   Fibronectin↓, 1,   LRP1↑, 1,   MLC2/MYL9↝, 1,   MMP13↓, 2,   MMP2↓, 2,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 4,   MMP9↑, 1,   MUC1↑, 2,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   Snail↑, 1,   p‑T-cadherin↓, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TGF-β1↓, 2,   TumCI↓, 1,   TumMeta↓, 1,   Twist↑, 1,   TXNIP↓, 2,   Tyro3↓, 1,   uPA↑, 1,   Vim↓, 3,   Vim↑, 1,   α-SMA↓, 10,   α-SMA↑, 1,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 2,   Hif1a↓, 3,   Hif1a↑, 1,   LOX1↓, 1,   NO↓, 15,   TXA2↓, 1,   VCAM-1↓, 6,   VEGF↓, 5,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 8,   BBB↝, 1,   GastroP↑, 9,   GLUT2↑, 1,   GLUT3↑, 1,   GLUT4↑, 3,   H+/K+-ATPase↓, 1,   IBI↑, 4,   memfluid↑, 1,   MMP↓, 1,   MMP↑, 10,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   OCLN↝, 1,   TJ↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   TRPV3↑, 1,   ZO-1↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD19↑, 1,   CD4+↑, 3,   CD40↓, 1,   COX1↓, 3,   COX2/PTGS2↓, 34,   COX2/PTGS2↑, 2,   CXCL1↓, 1,   HMGB1↓, 1,   ICAM-1↓, 6,   IFN-γ↓, 10,   IL1?, 1,   IL1↓, 1,   IL10↓, 7,   IL10↑, 10,   IL12↓, 2,   IL17↓, 6,   IL18↓, 2,   IL1β↓, 37,   IL2↓, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 5,   IL4↑, 1,   IL5↓, 1,   IL6?, 1,   IL6↓, 48,   IL6↑, 2,   IL8↓, 7,   Imm↓, 1,   Imm↑, 20,   Imm↝, 2,   Inflam↓, 149,   Inflam↑, 1,   IP-10/CXCL-10↓, 1,   IRF3↓, 1,   LPS↓, 2,   LTA/TNF-β↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 5,   MCT1↓, 1,   MIP2↓, 1,   MyD88↓, 4,   NeuroI↓, 2,   NF-kB↓, 64,   NK cell↑, 1,   NLRP3↓, 14,   NLRP3↑, 1,   p65↓, 3,   PGE2↓, 14,   RAGE↓, 1,   RANTES↓, 1,   TLR2↓, 1,   TLR4↓, 16,   TNF-α↓, 69,   TNF-α↑, 3,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

Astr↓, 1,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 4,   Ach↑, 3,   AChE↓, 22,   AChE∅, 1,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 14,   ChAT↑, 3,   GABA↑, 1,   MAOA↓, 2,   MAOB↓, 2,   NGF↑, 3,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   APP↓, 1,   Aβ↓, 21,   Aβ42↓, 1,   BACE/β-secretase↓, 7,   PSEN1/PS1↓, 1,   PSEN2/PS-2↓, 1,   tau↓, 2,   p‑tau↓, 5,   β-Amyloid↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 2,   ACE2↓, 1,   BNP↓, 1,   CYP19↓, 1,   Leptin↓, 1,   PPARα↑, 4,   PPARα↝, 1,   PPARγ↓, 2,   PPARγ↑, 8,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 31,   BioAv↑, 34,   BioAv↝, 21,   BioEnh↑, 3,   ChemoSen↑, 3,   CompStab↑, 1,   CompStab↝, 1,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 49,   eff↑, 20,   eff↝, 2,   GSTA1↑, 1,   Half-Life↓, 6,   Half-Life↑, 2,   Half-Life↝, 12,   P-gp/ABCB1↓, 3,   P450↓, 2,   P450↑, 2,   P450↝, 1,   selectivity↑, 1,   Synergy↑, 13,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 73,   ALAT↑, 1,   ALB↑, 1,   ALP↓, 15,   AST↓, 72,   AST↑, 1,   BG↓, 5,   Bil↓, 4,   Bil↑, 2,   BloodF↑, 2,   BMD↑, 5,   BP↓, 5,   BUN?, 1,   BUN↓, 3,   creat↓, 11,   CRP↓, 6,   hs-CRP↓, 2,   IL6?, 1,   IL6↓, 48,   IL6↑, 2,   IRes↑, 1,   IRes↝, 1,   LDH↓, 16,   LDH↑, 1,   NOS2↓, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 5,   TMAO↓, 1,   Urea↓, 3,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 4,   AntiAge↑, 8,   antiAll↑, 18,   AntiArt↑, 10,   AntiCan↑, 35,   antiCG↑, 2,   antiD↓, 1,   AntiDiabetic↓, 2,   AntiDiabetic↑, 45,   antiNeop↑, 1,   antiPs↑, 2,   AntiTum↑, 11,   cardioP?, 1,   cardioP↑, 74,   cardioP⇅, 1,   chemoP↑, 12,   chemoPv↑, 5,   cognitive↑, 26,   cough?, 1,   diuretic↑, 5,   fatigue↓, 3,   hepatoP↑, 269,   memory?, 1,   memory↑, 28,   Mood↑, 1,   motorD↓, 1,   motorD↑, 5,   Mucositis↓, 1,   neuroP?, 3,   neuroP↓, 1,   neuroP↑, 104,   Obesity↓, 21,   OS↑, 3,   Pain↓, 5,   PDE4↓, 1,   QoL↓, 1,   QoL↑, 1,   radioP↑, 7,   RenoP↓, 1,   RenoP↑, 48,   Sleep↑, 1,   SoreThr?, 1,   Stress↓, 2,   Stroke↓, 10,   toxicity↓, 31,   toxicity↑, 1,   toxicity↝, 13,   toxicity∅, 4,   Wound Healing↓, 1,   Wound Healing↑, 6,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 17,   AntiFungal↑, 10,   AntiViral↑, 14,   Bacteria↓, 31,   Bacteria↑, 1,   Diar↓, 3,   GutMicro↑, 25,   Sepsis↓, 4,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 2,   Ingr↝, 17,   Phen↑, 1,   QC↑, 1,  
Total Targets: 546

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
19 Silymarin (Milk Thistle) silibinin
10 Thymoquinone
9 Baicalein
8 Emodin
8 Selenium NanoParticles
7 Ferulic acid
6 Silver-NanoParticles
6 Chlorogenic acid
6 Chrysin
6 Dandelion Root
6 Hydrogen Gas
5 Resveratrol
5 Carvacrol
5 Kaempferol
5 Piperine
4 Allicin (mainly Garlic)
4 Curcumin
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Ashwagandha(Withaferin A)
4 Centella asiatica / Gotu kola → asiaticoside
4 Isoliquiritigenin
4 Licochalcone A
4 Moringa oleifera
3 Berberine
3 Boron
3 buckwheat sprouts
3 Rutin
3 Camu camu
3 Chemotherapy
3 Hibiscus sabdariffa
3 Honokiol
3 Hyperoside
3 Isovitexin
3 Luteolin
3 Matrine
3 Phycocyanin
3 Quercetin
3 Rosmarinic acid
3 Shikonin
2 Allyl isothiocyanate
2 Alpha-Lipoic-Acid
2 isoquercitrin
2 Apigenin (mainly Parsley)
2 Betulinic acid
2 Selenium
2 Vitamin C (Ascorbic Acid)
2 Propolis -bee glue
2 methotrexate
2 Hydroxycinnamic-acid
2 Crocetin
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Cucurbitacin
2 Chlorella (Chlorella vulgaris)
2 Cisplatin
2 Date Fruit Extract
2 Indole-3-carbinol
2 Flaxseed/Linseed
2 Linalool
2 Lycopene
2 Mung Bean Sprouts
2 Vitexin
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Ursolic acid
1 1,8-Cineole
1 Acer okamotoanum
1 Ascorbyl Palmitate
1 Melatonin
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Benzyl isothiocyanate
1 Phenethyl isothiocyanate
1 Bacopa monnieri
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Thymol-Thymus vulgaris
1 Chlorophyllin
1 Choline
1 Chyawanprash
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Calorie Restriction Mimetics
1 Carvone
1 Radiotherapy/Radiation
1 diet Fermented Foods
1 Diindolylmethane
1 D-limonene
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Sesame seeds and Oil
1 Fennel Oil/Foeniculum vulgare
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Inositol
1 Isorhamnetin
1 L-ornithine
1 Licorice
1 Lactoferrin/Talactoferrin
1 Metformin
1 Magnetic Fields
1 Moringin
1 Morin
1 Mucuna pruriens/Velvet Bean
1 Mistletoe/Viscum album Extracts
1 Mushroom Chaga, Inonotus obliquus
1 nicotinamide adenine dinucleotide
1 Neem
1 Patchouli Oil (Pogostemon cablin)
1 Piperlongumine
1 Pterostilbene
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Spirulina(Arthrospira/Limnospira)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1179  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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