TRPV1 Cancer Research Results

TRPV1, transient receptor potential vanilloid 1: Click to Expand ⟱
Source:
Type:
TRPV1 is a ligand-gated ion channel classically associated with nociception and heat sensation.
- TRPV1 is a nonselective cation channel that allows the influx of calcium (and other cations) when activated by various stimuli such as capsaicin, heat, or low pH.
- TRPV1 can influence key cellular processes including proliferation, apoptosis, and migration by modulating intracellular calcium levels and downstream signaling cascades.

- In some cases, TRPV1 activation can induce cell death, which might translate into less aggressive tumor behavior; however, this is not a universal finding.
- TRPV1 is a non-selective cation channel, which is frequently overexpressed in highly malignant cancers.
- Capsaicin may be able to induce cell death in urothelial cancer and glioma cells via TRPV1-dependent stimulation of excessive calcium (Ca2+) influx
- Activation of TRPV1 promotsd the generation of ROS.
- Variability in TRPV1 expression and function suggests that it might serve as one component of a broader prognostic panel rather than a standalone marker.
Scientific Papers found: Click to Expand⟱
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *Stroke↓, *Risk↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
2349- CAP,    The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease
- in-vivo, AD, NA
*TRPV1↑, *PKM2↓, *SREBP2↑, *memory↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NADH↓, 1,   RNS↑, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   p38↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   TOP1↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,   TumCP↑, 1,  

Migration(tgid=13) ⓘ

TRIB3↑, 1,   TumCMig↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,   MPT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   chemoPv↑, 1,   Obesity↓, 1,   RenoP↑, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   HO-1↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 1,   UCPs↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 1,   NADPH↓, 1,   PKM2↓, 1,   SIRT1↑, 2,   SREBP2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↑, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↑, 2,   Na+↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   MMP↑, 1,   Na+↑, 1,   TRPV1↑, 8,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL18↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 5,   NF-kB↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   tau↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   cardioP↑, 2,   cognitive↑, 1,   memory↑, 2,   motorD↓, 1,   neuroP↑, 2,   Pain↓, 3,   RenoP↑, 1,   Risk↓, 2,   Stroke↓, 1,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 53

Scientific Paper Hit Count for: TRPV1, transient receptor potential vanilloid 1
8 Capsaicin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1227  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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