compI Cancer Research Results

compI, mitochondrial complex-I: Click to Expand ⟱
Source:
Type:
Mitochondrial complex I (NADH:ubiquinone oxidoreductase) is the largest enzyme of the oxidative phosphorylation system. Its function is essential for bioenergetics and redox balance. Altered expression of its subunits can lead to changes in tumor metabolism, reactive oxygen species (ROS) generation, and apoptotic sensitivity—all of which may impact tumor growth and patient outcomes.

Commonly Reported Complex I Subunit:
-Increased expression of NDUFA4L2 has been associated with poor prognosis
-Reduced expression of core complex I subunits (such as NDUFS1 and NDUFS3) may correlate with a poorer overall survival in some cancers
-NDUFV1 have been linked to adverse clinical outcomes

-Dysregulation of complex I may alter ROS production. In some cancers, controlled ROS production can aid in signaling that promotes cell proliferation or survival, while excessive ROS can trigger cell death. Genes like NDUFA4L2 are also linked with hypoxia, a common feature in the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
8998- Citicoline,  Rad,    The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *compI↑, *compIII↑, *ATP↑, *Ca+2↓, *Iron↓, *Casp3↓, *glucose↝, *ACE/ACE1↑, *AChE↓,
8844- DIM,  I3C,    Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Imm↝, *BioAv↝, *Half-Life↝, *PKCδ↓, *TGF-β1↓, *PPARγ↓, *CEBPA↓, *FABP4↓, *AMPKα↑, *MCP1/CCL2↓, *IL6↓, *TNF-α↓, *Akt↑, *Inflam↓, *TMAO↓, *SREBF2⇅, *memfluid↑, *GutMicro↑, *Obesity↓, *hepatoP↑, *neuroP↑, *AntiAg↓, *Stroke↓, *AntiAg↓, *HDAC↑, *IL1β↓, *IL6↓, *iNOS↓, *IL4↑, *IL10↑, *Synergy↑, *compI↑, *ROS↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *cognitive↑, *Analgesic↑, *Pain↓, *BDNF↑, *TrkB↑, *Akt↑, *antiOx↑, *Apoptosis↓, *cardioP↑, *chemoP↑, *AntiThr↑, *uPA↑, *NRF2↑, *ARE↑, *HO-1↑, *Bacteria↓, *TOP1↓, *AntiFungal↑, *AntiViral↑, *radioP↑, *Synergy↑, *hepatoP↑, *Diar↓, *ChemoSen↑, *Telomerase↓, *BioAv↓,
7195- GBE,    Mitochondrial effects of Ginkgo biloba extract
- Review, AD, NA
*ROS↓, *mitResp↑, *AntiAge↑, *ATP↑, *neuroP↑, *ETC↑, *compI↑,
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,
8729- M-Blu,    Methylene blue modulates mitochondrial electron flow via multiple regulatory sites in isolated brain mitochondria: Implications for neurodegeneration
- in-vivo, AD, NA
*ETC↝, *compI↑, *H2O2↑, *other?,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   H2O2↑, 1,   HO-1↑, 1,   Iron↓, 1,   NRF2↑, 1,   ROS↓, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 6,   compII↑, 1,   compIII↑, 3,   compIV↑, 1,   compV↑, 1,   ETC↑, 2,   ETC↝, 1,   mitResp↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↑, 3,   FABP4↓, 1,   glucose↝, 1,   GlucoseCon↑, 1,   SREBF2⇅, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   Casp3↓, 1,   iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 2,   AMPKα↑, 1,   p‑ERK↑, 1,   PKCδ↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   HDAC↑, 1,   other?, 1,  

DNA Damage & Repair(tgid=10) ⓘ

Telomerase↓, 1,   TOP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 2,   Ca+2↓, 1,   TGF-β1↓, 1,   uPA↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   memfluid↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL1β↓, 1,   IL4↑, 1,   IL6↓, 2,   Imm↝, 1,   Inflam↓, 3,   MCP1/CCL2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,   MAOA↓, 1,   MAOB↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↑, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↝, 1,   Half-Life↝, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 2,   TMAO↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Analgesic↑, 1,   AntiAge↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 2,   neuroP?, 1,   neuroP↑, 2,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 1,   Stroke↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Diar↓, 1,   GutMicro↑, 1,  
Total Targets: 85

Scientific Paper Hit Count for: compI, mitochondrial complex-I
2 Methylene blue
1 Citicoline, CDP-Choline
1 Radiotherapy/Radiation
1 Diindolylmethane
1 Indole-3-carbinol
1 Ginkgo biloba
1 isoquercitrin
1 Morin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1228  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page