FGF21 Cancer Research Results

FGF21, FGF21: Click to Expand ⟱
Source:
Type:
Fibroblast Growth Factor 21 (FGF21). FGF21 is best known as a metabolic regulator involved in energy homeostasis.

– FGF21 is an endocrine member of the fibroblast growth factor family primarily secreted by the liver, but also produced by adipose tissue and skeletal muscle.
Scientific Papers found: Click to Expand⟱
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27/CDKN1B↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
2269- dietMet,    Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice
- in-vivo, Nor, NA
*adiP↑, *FGF↑, *Insulin↓, *glucose↓, *Akt↑, *GSH↓, *PTEN↓, *FGF21↑, *PIP3↑,
8417- Lyco,    Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling
- in-vivo, AD, NA
*cognitive↑, *FGF21↑, *ATP↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSTs↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   Ki-67↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,   Weight↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   mt-ROS↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 2,   ATP↑, 1,   glucose↓, 2,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   PFK↑, 1,   PIP3↑, 1,   PKM2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   mTOR↓, 1,   PTEN↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↑, 1,   IGF-1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

FGF21↑, 4,   PPARα↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   neuroP↑, 1,   OS↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 32

Scientific Paper Hit Count for: FGF21, FGF21
3 diet Methionine-Restricted Diet
1 Lycopene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1279  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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