NGF Cancer Research Results

NGF, Nerve Growth Factor: Click to Expand ⟱
Source:
Type:
Nerve Growth Factor (NGF) plays a crucial role in the development, maintenance, and survival of certain neurons. Its connection to Alzheimer’s disease (AD) has been well-studied, particularly because of its importance in cholinergic neurons of the basal forebrain, which are notably affected in AD.
-Loss of NGF signaling contributes to cholinergic deficits, a hallmark of AD pathology
Scientific Papers found: Click to Expand⟱
4265- CA,    Potential applications of nanomedicine for treating Parkinson's disease
- Review, Park, NA
*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,
3875- Carno,    Ionophore Ability of Carnosine and Its Trehalose Conjugate Assists Copper Signal in Triggering Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Activation In Vitro
- in-vitro, AD, NA
*IronCh↑, *CREB↑, *BDNF↑, *NGF↑, *antiOx↑, *ROS↓,
6650- Cen,    Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- Review, AD, NA
*BioAv↝, *BioAv↝, *MDA↓, *GSH↑, *SOD↑, *AChE↓, *memory↑, *Ki-67↑, *Catalase↑, *PI3K↑, *BDNF↑, *NGF↑, *ROS↓, *NRF2↑, *HO-1↑, *NQO1↑, *ATP↑, *OCR↑, *TNF-α↓, *PP2A↑, *GSK‐3β↓, *Bcl-2↑, *TrkB↑, *NOTCH1↑, *SOX2↑, *Nestin↑, *MDA↓, *MAOA↓, *MAOB↓, *GPx↑, *cognitive↑, *ROS↓, *neuroP↑, *glucose↓, *ALAT↓, *AST↓, *PFK↓, *Weight↓, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *cardioP↑, *GutMicro↑, *Sepsis↓, *BioAv↑,
7230- EGb 761,    Ginkgo biloba extract (EGb 761) promotes peripheral nerve regeneration and neovascularization after acellular nerve allografts in a rat model
- in-vivo, Nor, NA
*Dose↝, *NGF↑, *angioG↑, *VEGF↑, *SOX18↑, *CD133↑, *IL6↑,
6780- EGCG,    The pharmacological activity of epigallocatechin-3-gallate (EGCG) on Alzheimer's disease animal model: A systematic review
- Review, AD, NA
*neuroP↑, *tau↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *AChE↓, *TNF-α↓, *JNK↓, *NGF↑, *SOD↑, *GPx↑, *MDA↓, *NO↓, *ROS↓, *iNOS↓, *COX2/PTGS2↓, *BAX↓, *CHOP/DDIT3↓, *GRP78/BiP↓, *Bcl-2↑, *Dose↑, *BioAv↑, *hepatoP↓,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, *AChE↓, *Ach↑, *memory↑, *NGF↑, *BDNF↑,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *5HT↑, *cFos↑, *Aβ↓, *memory↑, *BDNF↑, *Ach↑, *AChE↓, *cognitive↑, *BDNF↑, *NGF↑, *β-catenin/ZEB1↑, *p‑Akt↓, *mTOR↓, *MMP1↓, *MMP9↓, *MMP-10↓, *TIMP1↑, *TIMP2↑,
8962- mushLions,    Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models
- Review, AD, NA
*NRF2↑, *antiOx↑, *Inflam↓, *neuroG↑, *cognitive↑, *Mood↑, *NGF↑, *BDNF↑, *IL6↓, *TNF-α↓, *neuroP↑, *Ingr↑, *Dose↝, *Learn↑, *memory↑,
8947- mushLions,    Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
- Trial, AD, NA
*Dose↝, *cognitive↑, *Ingr↝, *NGF↑,
8948- mushLions,    Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
- Trial, AD, NA
*Ingr↝, *NGF↑, *Dose?, *antiD↑, *ANXi↓,
8957- mushLions,    Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review
- Review, Nor, NA
*neuroP↑, *AntiTum↑, *antiOx↑, TumCP↓, *Inflam↓, TumCI↓, Casp↑, *GutMicro↑, *proBDNF↑, *BDNF↑, *Mood↑, *antiD↑, *ANXi↓, *Sleep↑, *cognitive↑, *Imm↑, *NGF↑, *AChE↓, *toxicity↓,
8964- mushLions,    Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review
- Review, Nor, NA - Review, AD, NA
*Ingr↝, *ROS↓, *antiOx↑, *AntiBio↑, *NGF↑, *neuroG↑, *memory↑, *neuroP↑, *NF-kB↓, *COX2/PTGS2↓, *NeuroI↓, *cognitive↑, *NRF2↑, *SOD↑, *GPx↑, *GutMicro↑, *BBB↑, *BioAv↝,
8960- mushLions,    Recent Advances in Erinacine A: Preparation, Biological Activities, and Biosynthetic Pathway
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *NGF↑, *other↝, *antiOx↑, *Inflam↓, *antiCG↑, *Bacteria↓, *hyperG↝, *AntiDiabetic↑, *AntiCan↑, *neuroG↑, *cognitive↑, *Stroke↓, *IL1β↓, *IL6↓, *TNF-α↓, *RNS↓, *iNOS↓, *MAPK↓, *CHOP/DDIT3↓, TumCD↓, ROS↑, TumCP↓, TumCI↓, ROCK1↓, LIMK2↓, Cofilin↓, PI3K↓, mTOR↓, P70S6K↓, TumCMig↓, TumMeta↓, TGF-β↓, MMP9↓, *AntiAge↑, *RIP1↓, *cl‑Casp8↓, *cl‑Casp3↓, *NRF2↑, *HO-1↑, *SOD1↑,
3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, *cognitive↑, *cognitive∅, *BBB↑, *NGF↑, *BDNF↑, *NO↓, *memory↑, *Aβ↓,
7517- Poly,    Modulation of neurotrophic signaling pathways by polyphenols
- Review, Nor, NA
*NRF2↑, *HO-1↑, *NGF↑, *BDNF↑, *neuroP↑, p‑CREB↑,
3948- Shank,    Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain
- in-vivo, AD, NA
*AChE↓, *ChAT↑, *NGF↑, *CDK5↓, *neuroP↑, *MDA↓,
4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *cardioP↑, *lipid-P↓, *cognitive↑, *neuroP↑, *Aβ↓, *NGF↑,

Showing Research Papers: 1 to 21 of 21

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 2,   GSH↓, 1,   HO-1↓, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 1,   ROS↑, 2,   SOD?, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 1,   TumCD↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   p‑CREB↑, 1,   EGFR↓, 1,   ERK↓, 1,   MAPK↑, 1,   mTOR↓, 2,   P70S6K↓, 2,   PI3K↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXO1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   mitA↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   TumCG↓, 1,   TumCP↓, 4,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   Cofilin↓, 1,   LAMs↓, 1,   LIMK2↓, 1,   MMP9↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 2,   PD-1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

NP/CIPN↓, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   ARE↑, 1,   Catalase↑, 5,   GPx↑, 4,   GSH↑, 5,   GSR↑, 1,   HO-1↓, 1,   HO-1↑, 3,   hyperG↝, 1,   Keap1↝, 1,   lipid-P↓, 3,   MDA↓, 8,   NQO1↑, 1,   NRF2↑, 8,   RNS↓, 1,   ROS↓, 11,   mt-ROS?, 1,   SOD↑, 7,   SOD1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   OCR↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   ATP↑, 2,   glucose↓, 2,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   H2S↑, 1,   PFK↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   ASC↓, 1,   BAX↓, 3,   Bcl-2↑, 3,   Casp1↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   cl‑Casp8↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   CREB↑, 1,   JNK↓, 1,   MAPK↓, 1,   mTOR↓, 1,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PP2A↑, 1,   RIP1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↝, 1,   SOX18↑, 1,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK5↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↑, 1,   cFos↑, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 3,   NOTCH1↑, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 2,   VCAM-1↓, 2,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   MMP↑, 2,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   COX2/PTGS2↑, 1,   ICAM-1↓, 1,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 5,   IL6↑, 1,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 9,   pol-M2 MC↑, 1,   NeuroI↓, 1,   NF-kB↓, 5,   NLRP3↓, 1,   TLR4↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 2,   AChE↓, 9,   ADAM10↑, 1,   BDNF↑, 15,   proBDNF↑, 1,   ChAT↑, 1,   MAOA↓, 2,   MAOB↓, 1,   NGF↑, 21,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 3,   Aβ42↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   BioAv↝, 4,   CYP2D6↓, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 3,   Half-Life↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 4,   IL6↓, 5,   IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   antiAll↑, 1,   AntiCan↑, 1,   antiCG↑, 2,   antiD↑, 2,   AntiDiabetic↑, 3,   AntiMyl↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   ANXi↓, 2,   cardioP↑, 4,   chemoP↑, 1,   cognitive↑, 12,   cognitive∅, 1,   hepatoP↓, 1,   hepatoP↑, 3,   Learn↑, 2,   memory↑, 8,   Mood↑, 2,   motorD↑, 1,   neuroP↑, 17,   Obesity↓, 2,   RenoP↓, 1,   RenoP↑, 1,   Sleep↑, 1,   Stroke↓, 3,   toxicity↓, 5,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 2,   Diar↓, 1,   GutMicro↑, 4,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↑, 1,   Ingr↝, 3,  
Total Targets: 171

Scientific Paper Hit Count for: NGF, Nerve Growth Factor
7 Mushroom Lion’s Mane, Hericium erinaceus
2 Hyperoside
1 Carnosic acid
1 Carnosine
1 Centella asiatica / Gotu kola → asiaticoside
1 Ginkgo biloba-EGb 761
1 EGCG (Epigallocatechin Gallate)
1 Formononetin
1 Huperzine A/Huperzia serrata
1 Lycopene
1 Magnetic Field Rotating
1 Magnetic Fields
1 Polyphenols
1 Shankhpushpi
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1360  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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