GSH Cancer Research Results

GSH, Glutathione: Click to Expand ⟱
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Glutathione (GSH) is a thiol antioxidant that scavenges reactive oxygen species (ROS), resulting in the formation of oxidized glutathione (GSSG). Decreased amounts of GSH and a decreased GSH/GSSG ratio in tissues are biomarkers of oxidative stress.
Glutathione is a powerful antioxidant found in every cell of the body, composed of three amino acids: cysteine, glutamine, and glycine. It plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting the immune system.
cancer cells can have elevated levels of glutathione, which may help them survive in the oxidative environment created by the immune response and chemotherapy. This can make cancer cells more resistant to treatment.
While glutathione can be obtained from certain foods (like fruits, vegetables, and meats), its absorption from supplements is debated. Some people take N-acetylcysteine (NAC) or other precursors to boost glutathione levels, but the effects on cancer prevention or treatment are still being studied.
Depleting glutathione (GSH) to raise reactive oxygen species (ROS) is a strategy that has been explored in cancer research and therapy.
Many cancer cells have altered redox states and may rely on GSH to survive. Increasing ROS levels can induce stress in these cells, potentially leading to cell death.
Certain drugs and compounds can deplete GSH levels. For example, agents like buthionine sulfoximine (BSO) inhibit the synthesis of GSH, leading to its depletion.
Cancer cells tend to exhibit higher levels of intracellular GSH, possibly as an adaptive response to a higher metabolism and thus higher steady-state levels of reactive oxygen species (ROS).

"...intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS)..."
"Cancer cells have a high level of GSH compared to normal cells."
"...cancer cells are affluent with high antioxidant levels, especially with GSH, whose appearance at an elevated concentration of ∼10 mM (10 times less in normal cells) detoxifies the cancer cells." "Therefore, GSH depletion can be assumed to be the key strategy to amplify the oxidative stress in cancer cells, enhancing the destruction of cancer cells by fruitful cancer therapy."

The loss of GSH is broadly known to be directly related to the apoptosis progression.
Scientific Papers found: Click to Expand⟱
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
3972- ACNs,    Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
- Review, AD, NA - Review, Park, NA
*cardioP↑, *neuroP↑, *Inflam↓, *antiOx↓, *GutMicro↑, *Half-Life↑, *LDL↓, *adiP↓, *HDL↑, *CRP↓, *IL1β↓, *Risk↓, *Risk↓, *cognitive↑, *memory↑, *other↑, *BOLD↑, *NO↓, *MDA↓, *GSH↑, *VitC↑, *SOD↑, *GPx↑, *eff↓, *eff↓, *eff↓, *eff↝, *Risk↓,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2/PTGS2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
2207- AgNPs,  TQ,    Protective effects of Nigella sativa L. seeds aqueous extract-based silver nanoparticles on sepsis-induced damages in rats
- in-vivo, Nor, NA
*eff↑, *RenoP↑, *hepatoP↑, *MDA↓, *SOD↑, *GSH↑, *TNF-α↓, *IL1β↓,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
5344- Ajoene,    Ajoene, a Stable Garlic By-Product, Has an Antioxidant Effect through Nrf2-Mediated Glutamate-Cysteine Ligase Induction in HepG2 Cells and Primary Hepatocytes
- in-vitro, Nor, HepG2
*Nrf1↑, *PKCδ↑, *GSH↑, *antiOx↑,
5354- AL,    Therapeutic Potential of Allicin-Rich Garlic Preparations: Emphasis on Clinical Evidence toward Upcoming Drugs Formulation
- Review, Var, NA
*LDL↓, *antiOx↑, AntiCan↑, *cardioP↑, *BP↓, *Weight↓, NK cell↑, *AntiDiabetic↑, *GSH↑,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *Synergy↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- Review, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
3270- ALA,    Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis
- Trial, AD, NA
*cognitive↑, *other↝, *neuroP↑, *IronCh↑, *ROS↓, *GSH↑,
3271- ALA,    Decrypting the potential role of α-lipoic acid in Alzheimer's disease
- Review, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *Inflam↓, *IronCh↑, *NRF2↑, *BBB↑, *GlucoseCon↑, *Ach↑, *ROS↓, *p‑tau↓, *Aβ↓, *cognitive↑, *Hif1a↑, *Ca+2↓, *GLUT3↑, *GLUT4↑, *HO-1↑, *VEGF↑, *PDKs↓, *PDH↑, *VCAM-1↓, *GSH↑, *NRF2↑, *hepatoP↑, *ChAT↑,
3272- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*antiOx↑, *glucose↑, *eNOS↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cardioP↑, *cognitive↑, *eff↓, *BBB↑, *IronCh↑, *GSH↑, *PKCδ↑, *ERK↑, *p38↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GLUT1↑, *Inflam↓,
3284- ALA,    Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson's Disease Model Induced by 6-OHDA
- vitro+vivo, Park, NA
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
3437- ALA,    Revisiting the molecular mechanisms of Alpha Lipoic Acid (ALA) actions on metabolism
- Review, Var, NA
*IronCh↑, *antiOx↑, *ROS↓, *GSH↑, *NF-kB↓, *AMPK⇅, *FAO↑, *GlucoseCon↑, *PI3K↑, *Akt?,
3438- ALA,    The Potent Antioxidant Alpha Lipoic Acid
- Review, NA, NA - Review, AD, NA
*antiOx↑, *cardioP↑, *cognitive↑, *AntiAge↑, *Inflam↓, *AntiCan↑, *neuroP↑, *IronCh↑, *ROS↑, *Weight↓, *Ach↑, *ROS↓, *GSH↑, *lipid-P↓, *memory↑, *NRF2↑, *ChAT↑, *GlucoseCon↑, *Acetyl-CoA↑,
3446- ALA,  CUR,    The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
- in-vivo, Nor, NA
*hepatoP↑, *α-SMA↓, *COL3A1↓, *ROS↓, *GSH↑, *ALAT↓, *AST↓, *ALP↓, *MDA↓,
3447- ALA,    Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells
- in-vitro, AD, SH-SY5Y
*ATP↑, *MMP↑, *ROS↓, *GlucoseCon↑, *GSH↑, *neuroP↑, *cognitive↑, *Ach↑, *Inflam↓, *Aβ↓, OXPHOS↓,
3448- ALA,    Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line
- in-vitro, Nor, NA
*Inflam↓, *ROS↓, *GSH↑, *GPx↑, *Casp3↓, *Casp9↓, *MMP↑,
3542- ALA,    Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
- Review, Var, NA
*antiOx↑, *VitE↑, *VitC↑, *GSH↑, *IronCh↑, *BioAv↑, *BBB↑,
3547- ALA,    Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
- Review, AD, NA - Review, Park, NA
*memory↑, *neuroP↑, *motorD↑, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *5HT↑, *lipid-P↓, *IronCh↑, *AChE↓, *Inflam↓, *GlucoseCon↑, *GLUT3↑, *GLUT4↑, NF-kB↓, *IGF-1↑, *IL1β↓, *TNF-α↓, *cognitive↑, *ChAT↑, *HO-1↑, *NQO1↑,
3545- ALA,    Potential therapeutic effects of alpha lipoic acid in memory disorders
- Review, AD, NA
*neuroP↑, *Inflam↓, *VCAM-1↓, *5HT↑, *memory↑, *BioAv↝, *Half-Life↓, *NF-kB↓, *antiOx↑, *IronCh↑, *ROS↓, *ATP↑, *ChAT↑, *Ach↑, *cognitive↑, *lipid-P↓, *VitC↑, *VitE↑, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *Aβ↓,
3544- ALA,    Alpha lipoic acid for dementia
- Review, AD, NA
*antiOx↑, *BBB↑, *VitC↑, *VitE↑, *GSH↑, *IronCh↑, *neuroP↑, *NO↓, *cognitive↑, *AntiAge↑, *memory↑, *ROS↓,
3543- ALA,    The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
- Study, AD, NA
*cognitive↑, *antiOx↑, *Inflam↓, *neuroP↑, *Ach↑, *ROS↓, *GlucoseCon↑, *lipid-P↓, *GSH↑, *Acetyl-CoA↑,
3541- ALA,    Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology
- Review, Var, NA
*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,
3539- ALA,    Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
- Review, AD, NA
*ROS↓, *IronCh↑, *GSH↑, *antiOx↑, *NRF2↑, *MMP9↓, *VCAM-1↓, *NF-kB↓, *cognitive↑, *Inflam↓, *BioAv↝, *BioAv↝, *BBB↑, *H2O2∅, *neuroP↑, *PKCδ↑, *ERK↑, *MAPK↑, *PI3K↑, *Akt↑, *PTEN↓, *AMPK↑, *GLUT4↑, *GlucoseCon↑, *BP↝, *Synergy↑, *ICAM-1↓, *VCAM-1↓, *Dose↝,
297- ALA,    Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
- Review, BC, SkBr3 - Review, neuroblastoma, SK-N-SH - Review, AD, NA
PDH↑, TumCG↓, ROS↑, AMPK↑, EGR4↓, Half-Life↓, BioAv↝, *GSH↑, *IronCh↑, *ROS↓, *antiOx↑, *neuroP↑, *Ach↑, *lipid-P↓, *IL1β↓, *IL6↓, TumCP↓, FDG↓, Apoptosis↑, AMPK↑, mTOR↓, EGFR↓, TumCI↓, TumCMig↓, *memory↑, *BioAv↑, *BioAv↝, *other↓, *other↝, *Half-Life↓, *BioAv↑, *ChAT↑, *GlucoseCon↑,
5319- ALC,    l-carnitine and cancer cachexia: Clinical and experimental aspects
- Review, Var, NA
fatigue↓, QoL↑, *GSH↑, Dose↝,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, CompStab↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
3676- Ash,    Effect of Withania somnifera (Ashwagandha) root extract on amelioration of oxidative stress and autoantibodies production in collagen-induced arthritic rats
- in-vivo, Arthritis, NA
*CRP↓, *ROS↓, *lipid-P↓, *GSTs↓, *GSH↑, *antiOx↑, *Inflam↓,
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP/DDIT3↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3164- Ash,    Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
- in-vitro, Nor, NA
*hepatoP↑, *IKKα↓, *NLRP3↓, *NRF2↑, *AMPK↑, *Inflam↓, *Apoptosis↓, *cl‑Casp3↓, *cl‑PARP1↓, *NLRP3↓, *ROS↓, *ALAT↓, *AST↓, *GSH↑,
4303- Ash,    Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review
- Review, AD, NA
*neuroP↑, *Sleep↑, *Inflam↓, *cardioP↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *IL6↓, *MCP1/CCL2↓, *lipid-P↓, *tau↓, *ROS↓, *BBB↑, *AChE↓, *GSH↑, *GSTs↑, *GSR↑, *GPx↑, *SOD↑, *Catalase↑, ChemoSen↑, *Strength↑,
5384- AsP,  MLT,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2/PTGS2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2613- Ba,    Hepatoprotective Effect of Baicalein Against Acetaminophen-Induced Acute Liver Injury in Mice
- in-vivo, Nor, NA
*hepatoP↑, *MDA↓, *SOD↑, *Catalase↑, *GSH↑, *MAPK↓, *p‑JAK2↓, *p‑STAT3↓, *ALAT↓, *AST↓, *ROS↓, *antiOx↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2758- BetA,    Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *SOD↑, *GSH↑, *p‑p38↓, *p‑JNK↓, *p‑ERK↓, *NRF2↑, *HO-1↑, *MAPK↓, *heparanase↑, *antiOx↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2761- BetA,    Betulinic acid increases lifespan and stress resistance via insulin/IGF-1 signaling pathway in Caenorhabditis elegans
- in-vivo, Nor, NA
Insulin↓, IGF-1↓, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *antiOx?,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
9175- BITC,  PEITC,  AITC,    Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
- Review, Nor, NA
*Inflam↓, *antiOx↑, *AntiBio↑, *BioAv↝, *BioAv↑, *TNF-α↓, *IL10↓, *antiAll↑, *NRF2↑, *SOD↑, *GPx↑, *HO-1↑, *NQO1↑, *GSH↑, *GSTs↑, *hepatoP↑, *MDA↓, *Catalase↑, *ROS↓, *ROS⇅, *ROS↑, *IP-10/CXCL-10↓, *CD40↓, STAT1↓, iNOS↓, STAT3↓, IL6↓, *MPO↓, Casp3↑, Casp8↑, Casp9↑, mtDam↑, compIV↓, Cyt‑c↑, SDH↓, AIF↑, p‑Akt↓, PTEN↑, MMP2↓, MMP9↓, TumCCA↑, CDK1↓, CDC25↓, *eff↑, *toxicity↝, *eff↑, *eff↑, EMT↓, *AntiAg↑,

Showing Research Papers: 1 to 50 of 331
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 331

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   Catalase↓, 5,   Catalase↑, 2,   Fenton↑, 2,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 2,   GSH↓, 11,   GSH↑, 3,   GSR↓, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↑, 2,   HO-1↓, 2,   HO-1↑, 6,   Iron↑, 1,   Iron↝, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 3,   NOX↓, 1,   NOX4↓, 1,   NOX4↑, 1,   NQO1↓, 2,   NQO1↑, 2,   NRF2↓, 3,   NRF2↑, 5,   NRF2∅, 1,   ROS↓, 12,   ROS↑, 40,   ROS⇅, 2,   i-ROS↑, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 3,   SOD2↑, 2,   Trx↓, 1,   TrxR↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   compI↓, 1,   compII↓, 1,   compIV↓, 1,   ETC↓, 1,   Insulin↓, 3,   mitResp↓, 1,   mtDam↑, 5,   OXPHOS↓, 1,   PDH↑, 1,   SDH↓, 1,   SIRT3↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

5LO↓, 1,   ALAT↓, 5,   AMPK↑, 7,   ATP↓, 2,   ATP↑, 1,   CAIX/CA9↑, 1,   FAO↑, 1,   FASN↓, 2,   FDG↓, 1,   glucose↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   GSK‐3β↑, 1,   p‑GSK‐3β↓, 2,   HK2↓, 3,   lactateProd↓, 5,   LDHA↓, 1,   LDL↓, 1,   NAD↑, 1,   NADPH↑, 2,   PKM2↓, 2,   polyA↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   TCA↓, 2,   TS↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AIF↑, 3,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 41,   ASC↓, 1,   BAD↑, 3,   Bak↓, 1,   Bak↑, 2,   BAX↓, 2,   BAX↑, 27,   Bax:Bcl2↑, 4,   Bcl-2↓, 27,   Bcl-2↑, 1,   Bcl-xL↓, 5,   BID↑, 2,   BIM↑, 3,   BOK↑, 1,   Casp↑, 5,   Casp↝, 1,   Casp1↓, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 34,   cl‑Casp3↑, 3,   Casp7↑, 4,   Casp8↑, 12,   Casp9↑, 21,   cl‑Casp9↑, 2,   cFLIP↓, 2,   Cyt‑c↑, 18,   Diablo↑, 3,   DR5↓, 1,   DR5↑, 7,   FADD↑, 1,   Fas↑, 6,   FasL↑, 1,   Ferroptosis↑, 2,   iNOS↓, 2,   Mcl-1↓, 2,   MDM2↓, 2,   p‑MDM2↓, 1,   NAIP↓, 1,   necrosis↑, 1,   p38↑, 2,   p‑p38↑, 2,   pS2/TFF1↓, 1,   survivin↓, 6,   TumCD↑, 1,   XIAP↓, 8,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 30,   Akt↑, 4,   p‑Akt↓, 7,   AKT1↓, 1,   Akt2↓, 1,   cMET↓, 2,   p‑cMET↑, 1,   cSrc↓, 1,   EGFR↓, 7,   EGFR↑, 2,   ERK↓, 14,   p‑ERK↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   HGF/c-Met↓, 2,   HRAS↓, 1,   IGF-1R↓, 3,   IKKα↓, 2,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   JNK↓, 2,   JNK↑, 5,   p‑JNK↓, 1,   p‑JNK↑, 2,   LIMK1↓, 1,   MAPK↓, 8,   MAPK↑, 4,   p‑MAPK↑, 1,   mTOR↓, 14,   p70S6↓, 1,   P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 23,   PI3K↑, 1,   p‑PI3K↓, 4,   PKCδ↓, 2,   PTEN↓, 1,   PTEN↑, 5,   Raf↓, 1,   RAS↓, 4,   RAS↑, 1,   RET↓, 1,   Sp1/3/4↓, 5,   p‑Src↓, 1,   STAT↓, 2,   STAT3↓, 21,   p‑STAT3↓, 2,   p‑STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF3↑, 1,   ATF4↑, 4,   cJun↓, 1,   cMyc↓, 10,   DNMT1↓, 2,   DNMTs↓, 1,   EZH2↓, 1,   FOXO↑, 1,   FOXO1↑, 1,   FOXO3↑, 1,   p‑FOXO3↓, 2,   FOXO4↑, 1,   H3↓, 1,   ac‑H3↓, 1,   H4↓, 1,   ac‑H4↓, 1,   HDAC↓, 6,   HDAC1↓, 3,   HDAC2↓, 4,   HDAC3↓, 3,   HDAC8↓, 1,   miR-34a↓, 2,   miR-34a↑, 1,   OCT4↓, 2,   other↓, 2,   other↑, 4,   other↝, 2,   SOX2↓, 3,   tumCV?, 1,   tumCV↓, 13,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   eIF2α↓, 1,   eIF2α↑, 3,   p‑eIF2α↑, 2,   ER Stress↑, 8,   GRP78/BiP↑, 2,   HSP27↓, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 3,   HSPs↑, 1,   IRE1↑, 1,   PERK↑, 2,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↑, 13,   DNArepair↑, 1,   hTERT/TERT↓, 1,   P53↓, 2,   P53↑, 20,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 5,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PARP1↑, 1,   PCNA↓, 8,   Telomerase↓, 2,   TOP1↓, 1,   TOP2↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 1,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 11,   CDK4↑, 1,   CDK6↓, 4,   CDK8↓, 1,   CHK1↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 8,   cycD1/CCND1↓, 18,   cycE/CCNE↓, 4,   Ki-67↓, 10,   mitA↑, 1,   P21↓, 1,   P21↑, 19,   p27/CDKN1B↑, 8,   pRB↓, 1,   RB1↓, 1,   Securin↓, 1,   TumCCA↑, 41,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP7/OP1↓, 2,   BMPs↑, 1,   CD133↓, 1,   CD34↓, 1,   cFos↓, 2,   cFos↑, 1,   CSCs?, 1,   CSCs↓, 4,   FGF↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   IGF-1↓, 3,   IGFBP3↑, 1,   Ki-67↓, 10,   mTORC1↓, 1,   Nanog↓, 3,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 3,   SCF↓, 1,   Shh↓, 2,   STAT1↓, 1,   TumCG↓, 16,   TumCG↑, 2,   TumCP↓, 30,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 3,   AXL↓, 2,   BACH1↓, 1,   Ca+2↑, 4,   i-Ca+2↑, 1,   Cdc42↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 8,   EMT↓, 16,   EMT↝, 1,   F-actin↓, 1,   FAK↓, 1,   p‑FAK↓, 1,   ITGB1↓, 1,   KRAS↓, 2,   LAMs↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 2,   MMP13↓, 1,   MMP2↓, 16,   MMP7↓, 1,   MMP9↓, 17,   MMP9↑, 1,   MMPs↓, 7,   MUC4↓, 1,   N-cadherin↓, 7,   Rac1↓, 1,   Rho↓, 1,   Rho↝, 1,   Slug↓, 2,   Smad1↑, 1,   Snail↓, 3,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 3,   TIMP2↑, 2,   TRIB3↑, 1,   TumCI↓, 12,   TumCMig↓, 14,   TumMeta↓, 10,   TumMeta↑, 3,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 4,   uPAR↓, 1,   Vim↓, 6,   Vim↑, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   CD31/PECAM-1↓, 1,   EGR4↓, 1,   Hif1a↓, 13,   NO↓, 1,   NO↑, 2,   VEGF↓, 21,   VEGFR2/KDR/Flk1↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CLDN1↓, 1,   GLUT1↓, 1,   GLUT1↑, 1,   GLUT3↑, 1,   MMP↓, 18,   TRPM7↓, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD44↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 20,   COX2/PTGS2↑, 1,   CXCc↓, 1,   CXCR3↓, 1,   CXCR4↓, 5,   DR4↑, 2,   Eos↑, 1,   FOXP3↓, 1,   HMGB1↓, 1,   ICAM-1↓, 3,   IL10↑, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 12,   IL8↓, 3,   Imm↑, 3,   INF-γ↝, 1,   Inflam↓, 8,   MCP1/CCL2↓, 1,   Neut↑, 2,   NF-kB↓, 38,   NF-kB↑, 2,   NK cell↑, 3,   NLRP3↓, 3,   p65↓, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 2,   PGE1↓, 1,   PGE2↓, 7,   PSA↓, 2,   Resistin↓, 1,   T-Cell↑, 2,   TCF↓, 1,   Th1 response↑, 1,   TLR4↓, 2,   TNF-α↓, 8,   TNF-α↑, 1,   Treg lymp↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AR↓, 3,   ER-α36↓, 1,   ER(estro)↓, 1,   Irisin↓, 1,   Leptin↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   PPARγ↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 6,   chemoR↓, 1,   ChemoSen↓, 2,   ChemoSen↑, 40,   CompStab↓, 2,   CompStab↝, 1,   CYP1A1↓, 1,   DDS↑, 1,   Dose↓, 1,   Dose↝, 9,   Dose∅, 1,   eff↓, 1,   eff↑, 20,   eff↝, 1,   GSTM1↑, 1,   Half-Life↓, 1,   Half-Life↝, 3,   MDR1↓, 2,   P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   RadioS↑, 15,   selectivity?, 1,   selectivity↑, 18,   Synergy↑, 24,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   ALAT↓, 5,   ALP↓, 2,   AR↓, 3,   AST↓, 4,   BMD↑, 1,   BRCA1↑, 1,   BUN↓, 2,   CA19-9↓, 1,   CEA↓, 3,   creat↓, 2,   CRP↓, 2,   E6↓, 1,   E7↓, 1,   EGFR↓, 7,   EGFR↑, 2,   EZH2↓, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 12,   KRAS↓, 2,   LDH↓, 1,   NSE↓, 1,   PC↑, 1,   PD-L1↓, 2,   PSA↓, 2,   RBC↑, 1,   TG/TAG↓, 1,   TRIB3↑, 1,   WBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 16,   AntiTum↑, 5,   BowelM↑, 1,   cachexia↓, 1,   cardioP↑, 5,   CardioT↓, 1,   chemoP↑, 17,   chemoPv↑, 5,   ChemoSideEff↓, 5,   cognitive↑, 4,   fatigue↓, 1,   hepatoP↑, 7,   Mucositis↓, 1,   neuroP↑, 5,   NP/CIPN↓, 1,   OS↓, 1,   OS↑, 5,   Pain↓, 1,   QoL↑, 2,   radioP↑, 8,   Remission↑, 1,   RenoP↑, 5,   Risk↓, 1,   toxicity↓, 2,   TumVol?, 1,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,   Ingr↝, 2,  
Total Targets: 505

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 2,   antiOx?, 1,   antiOx↓, 9,   antiOx↑, 148,   ARE↑, 4,   Bil↓, 1,   Catalase↓, 2,   Catalase↑, 130,   Catalase↝, 1,   Copper↓, 2,   Fenton↓, 3,   GCLC↑, 2,   GCLM↑, 1,   GPx↓, 1,   GPx↑, 85,   GPx↝, 1,   GPx4↑, 7,   GSH↑, 335,   GSH/GSSG↓, 1,   GSH/GSSG↑, 3,   GSR↓, 3,   GSR↑, 20,   GSS↑, 1,   GSSG↓, 6,   GSTs↓, 4,   GSTs↑, 29,   H2O2↓, 11,   H2O2↑, 1,   H2O2∅, 1,   HDL↓, 1,   HDL↑, 5,   HNE↓, 1,   HO-1↓, 3,   HO-1↑, 83,   HO-1⇅, 1,   HO-2↓, 1,   Iron↓, 3,   i-Iron↓, 1,   Keap1↓, 6,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 93,   lipid-P↑, 1,   MDA?, 1,   MDA↓, 133,   MDA↑, 3,   MPO↓, 15,   NADH↓, 1,   NOX↓, 2,   NOX4↓, 3,   NQO1↑, 22,   Nrf1↑, 3,   NRF2↓, 5,   NRF2↑, 138,   NRF2⇅, 1,   Prx↑, 4,   RNS↓, 3,   ROS?, 3,   ROS↓, 250,   ROS↑, 4,   ROS⇅, 2,   ROS∅, 1,   mt-ROS?, 1,   mt-ROS↓, 1,   selenoP↑, 1,   SOD?, 1,   SOD↓, 3,   SOD↑, 189,   SOD↝, 1,   SOD1↑, 3,   SOD2↑, 3,   TAC↑, 18,   TBARS↓, 9,   TBARS↑, 1,   Thiols↑, 1,   TOS↓, 2,   Trx↑, 7,   Trx1↑, 3,   TrxR↑, 3,   TrxR1↑, 1,   uricA↓, 2,   VitC↑, 11,   VitE↑, 8,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 2,   FPN↑, 1,   IronCh↓, 1,   IronCh↑, 19,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 2,   FIS1↓, 1,   HSP60/HSPD1↓, 1,   Insulin↑, 2,   MFN2↑, 2,   mitResp↑, 2,   mtDam↓, 5,   mtDam↑, 1,   NGB↑, 1,   OCR↑, 1,   PDH↑, 1,   PGC-1α↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   SIRT3↑, 2,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   5LO↓, 5,   ACC↓, 1,   ACC↑, 1,   Acetyl-CoA↑, 2,   ACSL4↓, 2,   adiP↓, 1,   ALAT↓, 45,   AMP↓, 1,   AMPK↓, 2,   AMPK↑, 18,   AMPK⇅, 1,   ATP↓, 1,   ATP↑, 14,   cAMP↑, 1,   CPT1A↑, 1,   CRM↑, 2,   FAO↑, 1,   FASN↓, 3,   FFA/NEFA↓, 1,   G6PD↑, 1,   GAPDH↑, 1,   glucose↓, 6,   glucose↑, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 12,   GlutMet↑, 1,   Glycolysis↑, 1,   Glycolysis↝, 1,   GSK‐3β↓, 10,   GSK‐3β↑, 5,   H2S↑, 4,   HK2↓, 1,   HK2↑, 2,   HMG-CoA↓, 2,   IDH1↑, 1,   lactateProd↓, 1,   LDHA↓, 1,   LDHA↑, 1,   LDL↓, 16,   lipidLev↓, 1,   NAD↓, 1,   NAD↑, 1,   NADPH↓, 7,   NADPH↑, 7,   NADPH∅, 1,   PDKs↓, 1,   PFK↓, 1,   PFK↑, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PLA2↓, 1,   PONs↑, 1,   PPP↓, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 18,   SIRT2↑, 1,   SREBP1/SREBF1↓, 4,  

Cell Death(tgid=5) ⓘ

AIF↓, 2,   APAF1↓, 1,   Apoptosis↓, 28,   ASC↓, 1,   BAD↓, 1,   BAX↓, 21,   BAX↑, 2,   Bax:Bcl2↓, 2,   Bcl-2↓, 1,   Bcl-2↑, 20,   Bcl-2↝, 1,   Casp↓, 1,   Casp1↓, 3,   Casp3↓, 40,   cl‑Casp3↓, 5,   proCasp3↓, 1,   proCasp3↑, 1,   Casp7↓, 1,   Casp8↓, 2,   Casp9↓, 13,   cl‑Casp9↓, 1,   Cyt‑c↓, 10,   Cyt‑c↑, 1,   Fas↓, 2,   Ferroptosis↓, 8,   GSDMD↓, 1,   iNOS↓, 41,   iNOS↑, 1,   necrosis↓, 2,   p38↓, 4,   p38↑, 2,   p‑p38↓, 3,   survivin↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 7,   Akt↑, 18,   p‑Akt↓, 3,   p‑Akt↑, 1,   AMPKα↑, 1,   CREB↑, 2,   p‑CREB↑, 3,   ERK↓, 7,   ERK↑, 6,   p‑ERK↓, 2,   p‑ERK↑, 1,   HCAR2↑, 1,   HGF/c-Met↑, 1,   IKKα↓, 2,   IKKα↑, 1,   p‑IKKα↓, 1,   JAK2↓, 1,   JAK2↑, 1,   p‑JAK2↓, 1,   JNK↓, 8,   JNK↑, 1,   p‑JNK↓, 4,   MAPK?, 1,   MAPK↓, 14,   MAPK↑, 5,   MAPK↝, 1,   p‑MAPK↓, 1,   Mst1↓, 1,   mTOR↓, 1,   mTOR↑, 4,   p‑mTOR↓, 2,   PDGFR-BB↓, 1,   PDGFRB↓, 1,   PI3K↓, 4,   PI3K↑, 17,   PKA↑, 1,   PKCδ?, 1,   PKCδ↑, 4,   PP2A↑, 3,   PTEN↓, 3,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 2,   STAT3↓, 5,   STAT3↑, 2,   p‑STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   ATF2↑, 1,   ATF4↓, 3,   ATF4↑, 1,   cJun↓, 1,   cMyc↓, 1,   p‑cMyc↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   FOXO1↝, 1,   FOXO3↑, 2,   HDAC?, 1,   HDAC↓, 3,   HDAC2↓, 1,   OCT4↓, 1,   other?, 4,   other↓, 3,   other↑, 10,   other↝, 14,   SOX2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 3,   CHOP/DDIT3↑, 1,   ER Stress↓, 3,   GRP78/BiP↓, 2,   GRP78/BiP↑, 2,   GRP94↑, 1,   HSP27↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 9,   HSPs↓, 1,   HSPs↑, 3,   PERK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 3,   Beclin-1/ATG6↑, 4,   LC3II↓, 1,   LC3II↑, 3,   p62↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 14,   P53↓, 2,   PARP↓, 1,   cl‑PARP↓, 1,   PARP1↓, 1,   cl‑PARP1↓, 1,   PCNA↓, 1,   SIRT6↑, 1,   γH2AX↓, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDK5↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   GADD34↓, 1,   Ki-67↓, 1,   Ki-67↑, 1,   P21↓, 2,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1↑, 2,   Ki-67↓, 1,   Ki-67↑, 1,   Nestin↑, 1,   neuroG↑, 1,   NOTCH1↑, 1,   p300↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 5,   AP-1↓, 2,   ATPase↑, 1,   BACH1↓, 1,   Ca+2↓, 9,   Ca+2↝, 1,   Cartilage↑, 1,   COL1↓, 3,   COL1↑, 1,   COL3A1↓, 2,   E-cadherin↑, 1,   EMT↓, 1,   Fibronectin↓, 1,   heparanase↑, 1,   LRP1↑, 1,   MMP13↓, 2,   MMP2↓, 5,   MMP2↑, 1,   MMP3↓, 1,   MMP9↓, 11,   MMP9↑, 1,   MMPs↓, 2,   MUC1↑, 2,   p‑Rac1↓, 1,   ROCK1↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TG2/TGase↓, 1,   TGF-β↓, 8,   TGF-β↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   TumCI↓, 1,   TXNIP↓, 3,   Vim↓, 2,   α-SMA↓, 9,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 2,   E-sel↓, 1,   eNOS↓, 1,   eNOS↑, 3,   p‑eNOS↑, 1,   Hif1a↓, 2,   Hif1a↑, 1,   LOX1↓, 1,   NO?, 1,   NO↓, 37,   NO↑, 4,   VCAM-1↓, 10,   VEGF↓, 2,   VEGF↑, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 1,   BBB↑, 37,   BBB↝, 1,   CLDN1↓, 1,   CLDN1↑, 1,   GastroP↑, 9,   GLUT1↑, 1,   GLUT2↑, 1,   GLUT3↑, 2,   GLUT4↑, 7,   H+/K+-ATPase↓, 1,   IBI↑, 3,   MMP↓, 1,   MMP↑, 19,   MMP↝, 1,   NHE3↑, 1,   OATPs↓, 1,   OCLN↓, 1,   OCLN↑, 1,   TJ↑, 1,   TRPC1↓, 1,   TRPM7↓, 1,   ZO-1↓, 1,   ZO-1↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   CB2 / CNR2↑, 1,   CD4+↑, 1,   CD40↓, 1,   CD8+↑, 1,   COX1↓, 3,   COX2/PTGS2↓, 52,   COX2/PTGS2↑, 2,   HCAR2↑, 1,   HMGB1↓, 1,   ICAM-1↓, 7,   IFN-γ↓, 11,   IFN-γ↑, 1,   IL1↓, 4,   IL10↓, 13,   IL10↑, 12,   IL12↓, 3,   IL17↓, 5,   IL18↓, 2,   IL1β↓, 76,   IL1β↑, 1,   IL2↓, 4,   IL22↓, 1,   IL23↓, 2,   IL33↓, 1,   IL4↓, 7,   IL4↑, 4,   IL5↓, 2,   IL5↑, 1,   IL6↓, 66,   IL6↑, 4,   IL8↓, 9,   Imm↓, 1,   Imm↑, 7,   INF-γ↓, 1,   Inflam↓, 150,   Inflam↑, 3,   IP-10/CXCL-10↓, 2,   IRF3↓, 2,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 8,   MIP2↓, 1,   MyD88↓, 5,   NeuroI↓, 5,   NF-kB↓, 94,   NF-kB↑, 2,   NK cell↑, 1,   NLRP3↓, 14,   p65↓, 4,   PGE2↓, 16,   PGE2↑, 2,   RAGE↓, 2,   RANTES↓, 1,   TLR1↓, 1,   TLR2↓, 4,   TLR4↓, 20,   TNF-α↓, 104,   TNF-α↑, 2,   TRAF1↓, 1,   TRAF6↓, 1,   TRIF↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 3,   GGT/CD224↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 9,   Ach↑, 11,   AChE↓, 47,   AChE↑, 1,   AChE∅, 1,   ADAM10↑, 3,   BChE↓, 11,   BDNF↓, 1,   BDNF↑, 31,   BDNF∅, 1,   BrainVol↑, 1,   ChAT↑, 7,   ChE↓, 1,   EndoR↑, 1,   GABA↑, 2,   MAOA↓, 5,   MAOB↓, 3,   monoA↑, 1,   NGF↑, 5,   PSD95↑, 2,   RELN↑, 1,   SNAP25↑, 2,   TrkB↑, 3,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 4,   APP↓, 6,   Aβ↓, 43,   Aβ42↓, 4,   BACE/β-secretase↓, 17,   IDE↑, 1,   PSEN1/PS1↓, 1,   tau↓, 9,   p‑tau↓, 16,   XO↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   ER(estro)↑, 1,   FGF21↑, 1,   GR↑, 3,   GR↝, 1,   PPARα↑, 4,   PPARα↝, 1,   PPARγ↑, 8,   RAAS↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   BioAv↓, 24,   BioAv↑, 44,   BioAv⇅, 1,   BioAv↝, 22,   BioEnh↑, 3,   ChemoSen↑, 2,   CYP2D6↓, 1,   CYP2E1↓, 2,   Dose?, 2,   Dose↑, 2,   Dose⇅, 1,   Dose↝, 34,   eff↓, 6,   eff↑, 33,   eff↝, 2,   GSTA1↑, 3,   Half-Life↓, 5,   Half-Life↑, 5,   Half-Life↝, 7,   P-gp/ABCB1↓, 4,   P450↓, 2,   P450↑, 2,   P450↝, 1,   Synergy↑, 16,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 45,   ALB↑, 1,   ALB↝, 1,   ALP↓, 11,   anemia↓, 1,   AST↓, 44,   BG↓, 2,   Bil↓, 1,   BloodF↑, 1,   BMD↑, 2,   BP↓, 8,   BP↝, 1,   BUN?, 1,   BUN↓, 3,   CEA↓, 2,   creat↓, 9,   CRP↓, 9,   Ferritin↓, 1,   Ferritin↑, 2,   HemoG↑, 1,   IL6↓, 66,   IL6↑, 4,   IRes↝, 1,   LDH↓, 14,   LDH↑, 1,   NOS2↓, 3,   RAGE↓, 2,   RBC↑, 1,   TC↓, 1,   TG/TAG↓, 4,   Urea↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 10,   antiAll?, 1,   antiAll↑, 10,   AntiArt↑, 6,   AntiCan↑, 16,   antiCG↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 24,   AntiMyl↑, 1,   antiNeop↑, 1,   antiPs↑, 1,   AntiTum↑, 1,   BOLD↑, 1,   cardioP?, 1,   cardioP↑, 56,   CardioT↓, 2,   chemoP↑, 13,   chemoPv↑, 4,   cognitive↓, 1,   cognitive↑, 65,   cognitive∅, 1,   diuretic↑, 1,   hepatoP↑, 78,   Learn↑, 7,   memory↑, 64,   Mood?, 1,   motorD↓, 1,   motorD↑, 9,   Mucositis↓, 1,   neuroP↑, 138,   NP/CIPN↓, 2,   Obesity↓, 10,   OS↑, 3,   Pain↓, 5,   radioP↑, 8,   RenoP↓, 1,   RenoP↑, 31,   RenoP↝, 1,   Risk↓, 4,   Sleep↑, 3,   Strength↑, 2,   Stress↓, 2,   Stroke↓, 12,   toxicity?, 1,   toxicity↓, 18,   toxicity↑, 2,   toxicity↝, 4,   toxicity∅, 7,   Weight↓, 3,   Weight↑, 1,   Weight∅, 1,   Wound Healing↓, 1,   Wound Healing↑, 7,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 9,   AntiFungal↑, 5,   AntiViral↑, 5,   Bacteria↓, 12,   Diar↓, 2,   GutMicro↑, 24,   Inf↓, 1,   Sepsis↓, 6,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Ingr?, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 633

Scientific Paper Hit Count for: GSH, Glutathione
23 Thymoquinone
18 Alpha-Lipoic-Acid
15 Silymarin (Milk Thistle) silibinin
14 Curcumin
9 Resveratrol
8 Luteolin
8 Quercetin
8 Rosmarinic acid
7 Selenium
7 Chemotherapy
7 Sulforaphane (mainly Broccoli)
7 Lycopene
6 Radiotherapy/Radiation
6 L-Theanine
6 Selenium NanoParticles
5 Silver-NanoParticles
5 Melatonin
5 Betulinic acid
5 Chlorogenic acid
5 doxorubicin
5 Propolis -bee glue
5 Shikonin
4 Allicin (mainly Garlic)
4 Ashwagandha(Withaferin A)
4 Boron
4 Rutin
4 Carnosic acid
4 Carvacrol
4 Chrysin
4 Ferulic acid
4 Fisetin
4 Honokiol
4 Hyperoside
4 Kaempferol
3 Berberine
3 Crocetin
3 D-limonene
3 Eugenol
3 Gallic acid
3 Isoliquiritigenin
3 Matrine
3 Piperine
3 Pterostilbene
2 Baicalein
2 Benzyl isothiocyanate
2 α-Bisabolol / Chamomile oil
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Cichoric acid / Chicoric acid
2 Citicoline, CDP-Choline
2 Carvone
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Cysteamine
2 Date Fruit Extract
2 diet Methionine-Restricted Diet
2 Dandelion Root
2 Cisplatin
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Sesame seeds and Oil
2 Ginkgo biloba
2 Hydrogen Gas
2 Hibiscus sabdariffa
2 Isovitexin
2 Licochalcone A
2 Lactoferrin/Talactoferrin
2 Linalool
2 Morin
2 Methylsulfonylmethane
2 Piperlongumine
2 chitosan
2 Selenite (Sodium)
2 Turmerones
2 Vitexin
1 1,8-Cineole
1 Anthocyanins
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Ascorbyl Palmitate
1 Baicalin
1 Beta-Caryophyllene
1 Phenethyl isothiocyanate
1 Allyl isothiocyanate
1 Boswellia (frankincense)
1 buckwheat sprouts
1 Butyrate
1 Centella asiatica / Gotu kola → asiaticoside
1 Chocolate
1 Chyawanprash
1 Carica papaya leaf extract
1 Galantamine
1 Ellagic acid
1 Exercise
1 Formononetin
1 Salvia officinalis
1 Lemon Balm/Melissa officinalis
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 Butein
1 Scopoletin
1 Isorhamnetin
1 isoorientin
1 isoquercitrin
1 Isothiocyanates
1 SDG/lignans
1 Magnolol
1 Methyl Jasmonate
1 Magnetic Fields
1 Moringa oleifera
1 Mushroom Lion’s Mane, Hericium erinaceus
1 N-Acetyl-Cysteine
1 Nimbolide
1 Oleuropein
1 HydroxyTyrosol
1 Patchouli Oil (Pogostemon cablin)
1 Phenylbutyrate
1 Parthenolide
1 Orlistat
1 polyethylene glycol
1 Anti-oxidants
1 Sesamin
1 Lignans
1 Shankhpushpi
1 Squalene
1 Taurine
1 methotrexate
1 Ursolic acid
1 Urolithin
1 Vitamin B12
1 Folic Acid, Vit B9
1 Vitamin C (Ascorbic Acid)
1 immunotherapy
1 Vitamin K2
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:137  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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