VGSC Cancer Research Results

VGSC, VGNC, Na+ voltage-gated channel: Click to Expand ⟱

Source:

Type:

Voltage-gated sodium channels (VGSCs or VGNCs) (Na+ voltage-gated channel)
-aberrant expression of VGSCs occurs in many cancers, where they contribute to invasion, metastasis, and tumor aggressiveness rather than electrical signaling.
-In most cancers studied to date, voltage-gated sodium channels (VGSCs) are upregulated and hyperactive compared with normal tissue.
-Blocking VGSCs consistently reduces metastasis behaviors

Scientific Papers found: Click to Expand⟱

5535-

MFrot,

Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells

in-vitro,

Nor,

 skeletal muscle cells

*Dose↝, *Vm/CMP↑, *Na+↑, *VGSC↑, *Vm/CMP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Migration(tgid=13) ⓘ

Na+↑, 1,

Barriers & Transport(tgid=15) ⓘ

Na+↑, 1, VGSC↑, 1, Vm/CMP↑, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,
Total Targets: 5

Scientific Paper Hit Count for: VGSC, VGNC, Na+ voltage-gated channel

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells