OCLN Cancer Research Results

OCLN, Occludin: Click to Expand ⟱
Source:
Type:
Occludin 
Target/Pathway: Occludin
Abbreviation: OCLN
Category: Tight junction / intestinal barrier
Direction in IBD: usually down
Cancer relevance: usually barrier-loss associated, especially in inflammation-linked colorectal cancer


Scientific Papers found: Click to Expand⟱
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *Synergy↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
8546- Matr,    Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice
- in-vivo, Stroke, NA
*Dose?, *Stroke↓, *BBB↝, *TJ↑, *ZO-1↑, *OCLN↑, *CLDN4↑, *HMGB1↓, *RAGE↓, *JNK↓, *p38↓, *ERK↓, *NF-kB↓, *IL1β↓, *IL6↓, *TNF-α↓, *BAX↓, *Bcl-2↑, *Apoptosis↓, *Iron↓, *ACSL4↓, *GPx4↑, *Ferroptosis↓, *neuroP↑, *Inflam↓, *antiOx↑,
9054- PatchO,    Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
- in-vivo, Col, NA
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
5935- TV,  CAR,    Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens
- in-vivo, Nor, NA
*Dose↝, *OCLN↑, *TLR2↓, *TNF-α↓, Bacteria↓, GutMicro↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   Risk↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 1,   HO-1↑, 1,   Iron↓, 1,   lipid-P↓, 1,   NRF2↑, 2,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 2,   Bcl-2↑, 2,   Casp3↓, 1,   Casp8↓, 1,   Ferroptosis↓, 1,   iNOS↓, 2,   iNOS↑, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

ERK↓, 2,   JNK↓, 1,   MAPK↑, 1,  

Migration(tgid=13) ⓘ

MUC1↑, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↝, 2,   CLDN1↑, 2,   CLDN3↑, 1,   CLDN4↑, 1,   IBI↑, 5,   MUC2↑, 1,   OCLN↑, 8,   TJ↑, 2,   ZO-1↑, 6,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↑, 1,   COX2/PTGS2↓, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL13↑, 1,   IL17↓, 1,   IL1β↓, 5,   IL6↓, 5,   Inflam↓, 6,   NF-kB↓, 4,   NF-kB↑, 1,   PGE2↓, 1,   RAGE↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 6,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 2,   eff↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 5,   RAGE↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   Stroke↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   GutMicro↑, 2,  
Total Targets: 76

Scientific Paper Hit Count for: OCLN, Occludin
2 Carvacrol
2 Patchouli Oil (Pogostemon cablin)
2 Thymol-Thymus vulgaris
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 isoorientin
1 Matrine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1463  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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