HSP70/HSPA5 Cancer Research Results

HSP70/HSPA5, heat shock proteins 70 kilodalton: Click to Expand ⟱
Source:
Type:
Also known as HSPA5
Enhanced expression of Hsp70 is associated with tumorigenesis for breast cancer, endometrial cancer, gastric cancer, and acute leukemia; with poor prognoses.
-These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascently translating proteins, promote the cellular or organellar transport of proteins, reduce proteotoxic protein aggregates and serve general housekeeping roles in maintaining protein homeostasis.
-HSP70 family of proteins can be thought of as a potent buffering system for cellular stress, either from extrinsic (physiological, viral and environmental) or intrinsic (replicative or oncogenic) stimuli. As such, this family serves a critical survival function in the cell. Not surprisingly, cancer cells rely heavily on this buffering system for survival. The overwhelming majority of human tumors overexpress HSP70 family members, and expression of these proteins is typically a marker for poor prognosis.
-HSP70 helps cancer cells survive under stressful conditions, such as hypoxia or nutrient deprivation, by preventing protein misfolding and aggregation. This allows cancer cells to maintain their proliferative capacity.
-Tumor Progression: Elevated levels of HSP70 have been associated with tumor progression and metastasis.
Scientific Papers found: Click to Expand⟱
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
9178- BITC,    Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2/HO-1 and NF-κB signaling pathways on indomethacin-induced gastric injury in rats
- in-vivo, Nor, NA
*GastroP↑, *GSH↑, *SOD↑, *NO↑, *PGE2↑, *MDA↓, *TNF-α↓, *MPO↓, *NRF2↑, *HO-1↑, *NADPH↑, *NQO1↑, *HSP70/HSPA5↑, *NF-kB↓, *Casp3↓, *Inflam↓, *ROS↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
3712- FA,    Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- Review, AD, NA
*antiOx↑, *Inflam↓, *ROS↓, *Aβ↓, *HO-1↑, *HSP70/HSPA5↑, *ERK↑, *Akt↑, *iNOS↓, *COX2/PTGS2↓, *cardioP↑, *memory↑, *IL2↓, *cognitive↑, *APP↓, *SOD↑, *Catalase↑, *Akt↑, *BioAv↑,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
9232- ITCs,  SFN,    The role of isothiocyanate-rich plants and supplements in neuropsychiatric disorders: a review and update
- Review, AD, NA
*ROS↓, *Inflam↓, *eff↑, *toxicity↓, *HDAC?, *neuroP↑, *NRF2↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑, *CHIP↑, *memory↑, *NeuroI↓, *ROS↓, *BACE/β-secretase↓, *BDNF↑, *GSH↑, *GPx↑, *AChE↓, *BChE↓, *TC↓, *TG/TAG↓, *LDL↓, ROS↑,
2253- MF,    Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *iNOS↓, *ROS↓, Catalase↑, *SOD↑, *HSP70/HSPA5↑, *neuroP↑, *motorD↑, *antiOx↑,
2254- MF,    Effect of 60 Hz electromagnetic fields on the activity of hsp70 promoter: an in vivo study
- in-vivo, Nor, NA
*HSP70/HSPA5↑, HSP70/HSPA5↑,
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
4105- MF,    Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases
- Review, AD, NA
*Inflam↓, *neuroP↑, *NO↑, *ROS↓, *NO↓, *MCP1/CCL2↑, *HSP70/HSPA5↑, *antiOx↑, *NRF2↑, *NF-kB↓,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1/CCL2↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3490- RF,    Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
- Review, AD, NA - Review, Park, NA
*OS↑, *memory↑, *cognitive↑, *memory↑, *Aβ↓, *eff↑, *HSF1↑, *HSP70/HSPA5↑,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3664- SFN,    Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*CHIP↑, *HSP70/HSPA5↑, *Aβ↓, *tau↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE/β-secretase↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,

Showing Research Papers: 1 to 20 of 20

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 20

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   BNIP3↝, 1,   Casp3↑, 1,   Fas↑, 1,   FasL↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JNK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

n-MYC↓, 1,   SOX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   Cyc↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 1,   Nestin↓, 1,   NOTCH2↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 2,   MMP9↓, 2,   NCAM↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Dose↝, 2,   P-gp/ABCB1⇅, 1,   RadioS↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   chemoPv↑, 1,   cognitive↑, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 8,   Catalase↑, 4,   GPx↑, 2,   GSH↑, 9,   GSR↓, 1,   HO-1↑, 6,   lipid-P↓, 1,   MDA↓, 6,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 3,   NRF2↑, 8,   ROS↓, 16,   SOD↑, 12,   SOD2↓, 1,   TBARS↓, 1,   TOS↓, 1,   Trx↓, 1,   TrxR↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GAPDH↑, 1,   LDL↓, 1,   NADPH↑, 1,   PONs↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAD↓, 1,   BAX↓, 4,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 4,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 1,   iNOS↓, 7,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 2,   p‑Akt↑, 1,   ERK↑, 1,   p‑ERK↑, 1,   JAK2↓, 1,   JNK↓, 1,   MAPK↓, 2,   PI3K↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC?, 1,   other↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSF1↑, 1,   HSP70/HSPA5↑, 20,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CHIP↑, 2,   Diff↑, 1,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 2,   COL1↑, 1,   LAMs↑, 1,   MMP2↓, 1,   MMP9↓, 5,   Smad1↑, 1,   TGF-β↑, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 3,   VCAM-1↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL2↑, 1,   IL6↓, 6,   Inflam↓, 11,   MCP1/CCL2↓, 1,   MCP1/CCL2↑, 1,   NeuroI↓, 1,   NF-kB↓, 5,   NLRP3↓, 1,   PGE2↓, 2,   PGE2↑, 2,   TNF-α↓, 7,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 5,   BACE/β-secretase↓, 4,   tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

RAAS↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose⇅, 1,   eff↑, 2,   eff↝, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   CRP↓, 1,   IL6↓, 6,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 3,   cognitive↑, 6,   hepatoP↑, 1,   memory↑, 5,   motorD↑, 2,   neuroP↑, 10,   OS↑, 1,   Pain↓, 1,   toxicity↓, 1,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,   Diar↓, 1,  
Total Targets: 131

Scientific Paper Hit Count for: HSP70/HSPA5, heat shock proteins 70 kilodalton
5 Magnetic Fields
4 Sulforaphane (mainly Broccoli)
1 Allicin (mainly Garlic)
1 Berberine
1 Biochanin A
1 Benzyl isothiocyanate
1 Boron
1 Celastrol
1 Chrysin
1 Ferulic acid
1 Graviola
1 Isothiocyanates
1 Propolis -bee glue
1 Radio Frequency
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:148  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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