TRPA1 Cancer Research Results

TRPA1, Transient Receptor Potential Ankyrin 1: Click to Expand ⟱
Source:
Type:

Transient Receptor Potential Ankyrin 1, a Ca²⁺-permeable, nonselective cation channel. It is best known as a sensory “irritant/pain” receptor activated by electrophilic/pungent compounds such as allyl isothiocyanate, allicin, cinnamaldehyde, eugenol, and some cannabinoids.

TRPA1 is biphasic/context-dependent in cancer.

Strategy Possible Effect Concern
TRPA1 inhibition May reduce oxidative-stress tolerance and improve chemosensitivity. Most compelling for breast/lung spheroid-type ROS-defense model.
TRPA1 activation In some models, strong activation causes Ca2+ overload, mitochondrial dysfunction, and apoptosis. Could also promote survival if activation is moderate or coupled to Ca2+ extrusion mechanisms.
Natural TRPA1 agonists Could be anticancer in some contexts. Could theoretically support survival in TRPA1-dependent cancers if dose/exposure creates adaptive Ca2+ signaling rather than overload.


Compound/Product TRPA1 Relationship Database Note
Allicin / Garlic TRPA1 agonist(activated) Strong overlap; garlic organosulfur compounds are classic TRPA1 activators.
Allyl isothiocyanate / Mustard / Wasabi / Crucifers Strong TRPA1 agonist Relevant if sulforaphane or crucifer compounds are tracked separately.
Cinnamaldehyde / Cinnamon TRPA1 agonist Good tag under cinnamon or cinnamaldehyde.
Eugenol / Clove TRPA1 agonist/modulator Good tag under eugenol.
Gingerol / Ginger TRPA1 agonist Relevant if ginger or gingerol is in the database.
Cannabidiol / Cannabinoids TRPA1 agonist/modulator Mechanistically relevant, but pharmacology is broad.
Oleocanthal / Olive oil phenolics TRPA1 activation linked to pungency Lower cancer-specific relevance than allicin, allyl isothiocyanate, or cinnamaldehyde.


Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE↓, *cardioP↑, MFN2↑,
6402- ANE,  FEO,    trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel
- in-vitro, Nor, HEK293
*TRPA1↑, *Dose↝, *Bacteria↓, *Inflam↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

MFN2↑, 1,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   cl‑Casp3⇅, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MAPK↝, 1,   p38↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

AntiBio↑, 1,   TRPA1↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↑, 1,   PPARγ↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  

Infection & Microbiome ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 34

Scientific Paper Hit Count for: TRPA1, Transient Receptor Potential Ankyrin 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1485  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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