MUC2 Cancer Research Results

MUC2, Mucin 2, oligomeric mucus/gel-forming: Click to Expand ⟱
Source:
Type:

MUC2 is the dominant intestinal gel-forming mucin and directly affects mucus barrier integrity, inflammation, microbiome interaction, colorectal cancer biology, immune exclusion, and drug penetration. Recent CRC work reports that MUC2 can act as a physical barrier limiting immune infiltration, and reviews describe mucin-rich barriers as contributing to immune evasion and therapy resistance.
Scientific Papers found: Click to Expand⟱
9054- PatchO,    Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
- in-vivo, Col, NA
*TNF-α↓, *IFN-γ↓, *IL1β↓, *IL6↓, *IL17↓, *iNOS↓, *COX2/PTGS2↓, *TJ↑, *ZO-1↑, *CLDN1↑, *OCLN↑, *MUC1↑, *MUC2↑, *Inflam↓, *IBI↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Migration(tgid=13) ⓘ

MUC1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,   IBI↑, 1,   MUC2↑, 1,   OCLN↑, 1,   TJ↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: MUC2, Mucin 2, oligomeric mucus/gel-forming
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1493  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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