TFAM Cancer Research Results

TFAM, Transcription factor A, mitochondrial: Click to Expand ⟱
Source:
Type:

TFAM, Transcription factor A, mitochondrial: Core mitochondrial transcription/mtDNA packaging factor; links directly to mitochondrial biogenesis, mtDNA copy number, oxidative stress, OXPHOS, aging, AD, and tumor metabolism.
-Therapeutic direction: Context-dependent; generally support/restore in AD, but tumor-stage and cancer-type specific in cancer.

Field Suggested Entry
Target TFAM
Full Name Transcription factor A, mitochondrial
Target Class Mitochondrial transcription factor; mtDNA packaging/nucleoid protein
Primary Biology mtDNA maintenance, mtDNA copy number regulation, mitochondrial transcription, mitochondrial biogenesis, nucleoid packaging, OXPHOS regulation
Cancer Relevance Medium and context-dependent: TFAM can support mitochondrial metabolism, OXPHOS, tumor stress tolerance, and progression in some cancers, but may also protect against mitochondrial instability and early tumorigenesis in other contexts
AD Relevance Medium-high: linked to impaired mitochondrial biogenesis, reduced mtDNA maintenance, oxidative stress, and neuronal energy dysfunction in AD and neurodegeneration
Therapeutic Direction Context-dependent. In AD/neurodegeneration, support or restore TFAM/PGC-1α/NRF1/NRF2 mitochondrial biogenesis signaling. In cancer, direction depends on tumor type, stage, and mitochondrial dependence.


Scientific Papers found: Click to Expand⟱
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
7811- ISQ,    Isoquercitrin alleviates OGD/R-induced oxidative stress and impaired mitochondrial biogenesis in SH-SY5Y cells via the NRF1/TFAM pathway
- in-vitro, Stroke, SH-SY5Y
*neuroP↑, *ROS↓, *Nrf1↓, *TFAM↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   H2O2↓, 1,   lipid-P↓, 1,   MDA↓, 1,   Nrf1↓, 1,   Nrf1↑, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 1,   SOD↑, 2,   TAC↑, 1,   TBARS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,   PGC-1α↑, 1,   PINK1↑, 1,   SIRT3↑, 1,   TFAM↑, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GSK‐3β↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Bcl-2↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑CREB↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   p62↓, 1,   PARK2↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   Inflam↓, 1,   NeuroI↓, 2,   NF-kB↓, 2,   NLRP3↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 1,   BDNF↑, 1,   ChAT↑, 1,   PSD95↑, 1,   RELN↑, 1,   SNAP25↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   PSEN1/PS1↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   Learn↑, 1,   memory↑, 1,   neuroP↑, 2,   NP/CIPN↓, 1,   Pain↓, 1,   Sleep↑, 1,  
Total Targets: 64

Scientific Paper Hit Count for: TFAM, Transcription factor A, mitochondrial
1 Beta-Caryophyllene
1 Cannabidiol
1 isoquercitrin
1 Melatonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1502  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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