mitA Cancer Research Results

mitA, Mitotic arrest: Click to Expand ⟱
Source:
Type:

Mitotic arrest is a cell-cycle state in which a cell is prevented from completing mitosis, usually because the spindle-assembly checkpoint detects improper chromosome alignment, defective kinetochore attachment, spindle damage, or incomplete chromosome segregation. Mitotic arrest commonly occurs during metaphase and is associated with sustained cyclin B1/CDK1 activity, checkpoint proteins such as MAD2, BUB1, BUBR1, and MPS1, and inhibition of the anaphase-promoting complex/cyclosome (APC/C).

In cancer cells, prolonged mitotic arrest may suppress tumour growth by preventing cell division and can lead to apoptosis, mitotic catastrophe, senescence, or abnormal exit from mitosis. Compounds that disrupt microtubules, centrosomes, kinetochores, or spindle-checkpoint signalling frequently induce mitotic arrest. However, some cells escape through mitotic slippage, which may produce polyploid or genetically unstable surviving cells.

Generally favourable anticancer direction: increased or prolonged mitotic arrest in tumour cells, particularly when followed by apoptosis or mitotic catastrophe. The effect should be interpreted cautiously if the study also reports mitotic slippage, polyploidy, or survival of genomically unstable cells.



Scientific Papers found: Click to Expand⟱
6690- DFC,    Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux
- in-vitro, Cerv, HeLa
Inflam↓, ROS↑, mitA↑, ChemoSen↑,
6862- FBZ,    Research: The Urgent Need for Clinical Studies to Evaluate the Anti-Tumor Efficacy of Fenbendazole
- Review, Var, NA
mitA↑, Apoptosis↑, GLUT4↓, HK2↓, Warburg↓, TumCCA↑, P53↑, Casp↑, TumCP↓, ROS↑, Ferroptosis↑, TumVol↓, Dose↝, BioAv↓, RadioS↝, ChemoSen↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   ROS↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

HK2↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

mitA↑, 2,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT4↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   Dose↝, 1,   RadioS↝, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: mitA, Mitotic arrest
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1523  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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