IGF-1R Cancer Research Results

IGF-1R, insulin-like growth factor-1 receptor: Click to Expand ⟱

Source: HalifaxProj(inhibit)

Type:

Also IGF1R
A link between elevated IGF levels and the development of solid tumors, such as breast, colon, and prostate cancer. Gene amplification of IGF1R, which encodes insulin-like growth factor 1 receptor, is a frequent event across cancer types. Upregulation of IGF1R protein expression in tumor samples and serum in NSCLC patients. Upregulation of IGF-IR signaling can help cancer cells resist anoikis by inhibiting p53 and p21 activation.
Many cancers, including breast, prostate, lung, and colorectal cancers, have been found to exhibit overexpression of IGF-1R. This overexpression can contribute to increased cell proliferation and survival, promoting tumor growth.

Scientific Papers found: Click to Expand⟱

9099-

CV,

Effect of a hot water extract of Chlorella vulgaris on proliferation of IEC-6 cells

in-vitro,

Nor,

IEC-6

*IGF-1R↑, *p‑FAK↑, *p‑Src↑, *MAPK↑, *PI3K↑, *Akt↑, *Wnt↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1, IGF-1R↑, 1, MAPK↑, 1, PI3K↑, 1, p‑Src↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt↝, 1,

Migration(tgid=13) ⓘ

p‑FAK↑, 1,
Total Targets: 7

Scientific Paper Hit Count for: IGF-1R, insulin-like growth factor-1 receptor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells