SCFAs Cancer Research Results

SCFAs, short-chain fatty acids: Click to Expand ⟱
Source:
Type:

SCFAs are a group of small fatty acids produced mainly by microbial fermentation of dietary fibre. The principal intestinal SCFAs are acetate, propionate, and butyrate, but they differ substantially in concentration, tissue distribution, receptors, metabolism, and anticancer effects.

SCFAs ↓ often reflects dysbiosis and impaired microbial fermentation.
SCFAs ↑ or restored is commonly considered beneficial.
Scientific Papers found: Click to Expand⟱
9037- CV,  SP,    Chlorella and Arthrospira (Spirulina) as Multi-Pathway Biological Response Modulators: Molecular Mechanisms, Signaling Pathways and Clinical Evidence
- Review, Nor, NA
*NRF2↑, *NF-kB↓, *antiOx↑, *BP↝, *GutMicro↑, *Ingr?, *Synergy↑, *antiOx↑, *ROS↓, *toxicity↝, *MMP↑, *ATP↑, *MitoP↑, *lipid-P↓, *MDA↓, *SOD↑, *GPx↑, *TAC↑, *NK cell↑, *IFN-γ↑, *CRP↓, *SCFAs↑, *TC↓, *LDL↓, *TG/TAG↓, *toxicity↝, AntiTum↑, Ki-67↓, ER-α36↓, P53↑, P21↑, TumCCA↑, Bax:Bcl2↑, Apoptosis↑, Synergy↑,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
7661- IP,    Enhancement of carbohydrate metabolism by probiotic and prebiotic intake promotes short-chain fatty acid production in the gut microbiome: a randomized, double-blind, placebo-controlled crossover trial
- Trial, Nor, NA
*PA↑, *Buty↑, *GutMicro↑, *SCFAs↑,
7664- IP,  GCL2505,    Administration of bifidobacteria and dietary fiber improves cognitive function by increasing short-chain fatty acid-producing bacteria and reducing inflammation
- Trial, AD, NA
*cognitive↑, *SCFAs↑, *GutMicro↑, *Buty↑, *AcOH↑, *neuroP↑,
7666- IP,    Short-chain fatty acid kinetics and concentrations are higher after inulin supplementation in young and older adults: a randomized trial
- Trial, Nor, NA
*Dose↝, *Buty↑, *PA↑, *AcOH↑, *SCFAs↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER-α36↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 2,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 2,   SOD↑, 2,   TAC↑, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AcOH↑, 2,   ATP↑, 1,   Buty↑, 4,   LDL↓, 1,   PA↑, 2,   SCFAs↑, 5,   SIRT1↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   ERK↑, 1,   JAK2↓, 1,   MAPK↓, 1,   PI3K↓, 1,   STAT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   Fibrosis↓, 1,   TGF-β1↓, 1,   α-SMA↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,   MMP↑, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IFN-γ↑, 1,   Inflam↓, 1,   NF-kB↓, 2,   NK cell↑, 1,   NLRP3↓, 1,   RAGE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GLP-1R↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 2,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BP↝, 1,   CRP↓, 1,   RAGE↓, 1,   TC↓, 1,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   diuretic↑, 1,   neuroP↑, 1,   RenoP↑, 1,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 4,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 58

Scientific Paper Hit Count for: SCFAs, short-chain fatty acids
3 Inulin Prebiotic
1 Chlorella (Chlorella vulgaris)
1 Spirulina(Arthrospira/Limnospira)
1 Fucoidan
1 Bifidobacterium animalis subsp. lactis GCL2505
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1563  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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