IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.


Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
5371- AV,    Assessment of the immunomodulatory effect of Aloe vera polysaccharides extracts on macrophages functions
- Study, Nor, NA
*eff↑, *IL6↑, *toxicity↓, *Imm↑,
2610- Ba,    Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice
- in-vivo, Nor, NA
*TNF-α↑, *IL6↑, *hepatoP↑,
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
*GutMicro↑, *IL6↑, *IL10↑, *IL17↑, *IFN-γ↑, PDGF↓, *RAD51↓,
2725- BetA,    Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice
- in-vivo, Nor, NA
*RenoP↑, *SOD?, *Catalase↑, *GSH↑, *ROS↓, *MDA↓, *IL1β↓, *TNF-α↓, *IL10↓, *IL6↑, *NRF2↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
7230- EGb 761,    Ginkgo biloba extract (EGb 761) promotes peripheral nerve regeneration and neovascularization after acellular nerve allografts in a rat model
- in-vivo, Nor, NA
*Dose↝, *NGF↑, *angioG↑, *VEGF↑, *SOX18↑, *CD133↑, *IL6↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
9294- MF,    Pulsed electromagnetic fields in muscle and tendon injuries: a narrative review of preclinical and clinical evidence
- Review, Nor, NA
*VEGF↑, *COL1↑, *IL6↑, *IL10↑, *Fibronectin↑, *Pain↓, *other↑, *Inflam↓,
3468- MF,    An integrative review of pulsed electromagnetic field therapy (PEMF) and wound healing
- Review, Nor, NA
*other↑, *necrosis↓, *IL6↑, *TGF-β↑, *iNOS↑, *MMP2↑, *MCP1/CCL2↑, *HO-1↑, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *BioAv↑, eff⇅, DNAdam↑, Apoptosis↑, ROS↑, TumCP↓, *ROS↓, *FGF↑,
3318- SIL,    Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight
- Review, AD, NA - Review, Park, NA
*hepatoP↑, *neuroP↑, *TLR4↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *memory↑, *cognitive↑, *NRF2↑, *HO-1↑, *ROS↓, *Akt↑, *mTOR↑, *SOD↑, *Catalase↑, *GSH↑, *IL10↑, *IL6↑, *NO↓, *MDA↓, *AChE↓, *MAPK↓, *BDNF↑,
3110- VitC,    Vitamin C Attenuates Oxidative Stress, Inflammation, and Apoptosis Induced by Acute Hypoxia through the Nrf2/Keap1 Signaling Pathway in Gibel Carp (Carassius gibelio)
- in-vivo, Nor, NA
*IL2↑, *IL6↑, *IL12↑, *NRF2↑, *Catalase↑, *SOD↑, *GPx↑, *GRP78/BiP↓, *ER Stress↓,

Showing Research Papers: 1 to 12 of 12

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTs↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bak↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   BID↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FGF↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

PDGF↓, 1,   TIMP2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   eff⇅, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CEA↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cognitive↑, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 6,   GPx↑, 1,   GSH↑, 5,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 3,   NRF2↑, 3,   ROS↓, 5,   SOD?, 1,   SOD↑, 5,   TBARS↓, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ATP↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   iNOS↓, 2,   iNOS↑, 1,   necrosis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   MAPK↓, 1,   mTOR↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ARNT↑, 1,   other↑, 2,   SOX18↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

RAD51↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↑, 1,   FGF↑, 1,   Jun↑, 1,  

Migration(tgid=13) ⓘ

COL1↑, 1,   Fibronectin↑, 1,   MMP13↓, 1,   MMP2↑, 1,   NFAM1↑, 1,   NFAT↑, 2,   TGF-β↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   Hif1a↑, 1,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   CD8+↑, 1,   COX2/PTGS2↓, 3,   CXCc↑, 1,   IFN-γ↑, 1,   IL10↓, 1,   IL10↑, 3,   IL12↑, 1,   IL17↑, 1,   IL1β↓, 4,   IL2↑, 2,   IL6↓, 2,   IL6↑, 12,   Imm↑, 2,   Inflam↓, 4,   LIF↑, 1,   MCP1/CCL2↑, 1,   NF-kB↓, 1,   OSM↑, 1,   TLR4↓, 1,   TNF-α↓, 6,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 2,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,   ARNT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   Dose↝, 1,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 1,   IL6↓, 2,   IL6↑, 12,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   cognitive↑, 1,   hepatoP↑, 2,   memory↑, 1,   motorD↑, 1,   neuroP↑, 3,   Pain↓, 2,   RenoP↑, 2,   toxicity↓, 2,   toxicity↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 2,   AntiFungal↑, 1,   GutMicro↑, 1,  
Total Targets: 101

Scientific Paper Hit Count for: IL6, Interleukin-6
2 Magnetic Fields
1 Allicin (mainly Garlic)
1 Aloe anthraquinones
1 Baicalein
1 Berberine
1 Betulinic acid
1 α-Bisabolol / Chamomile oil
1 Ginkgo biloba-EGb 761
1 Fisetin
1 Silymarin (Milk Thistle) silibinin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:158  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page