CX43/GJA1 Cancer Research Results

CX43/GJA1, Connexin 43 / Gap Junction Protein Alpha 1: Click to Expand ⟱
Source:
Type:

CX43 - Connexin 43 / Gap Junction Protein Alpha 1

Abbreviation: CX43, GJA1

Type: Gap junction / hemichannel protein

Function: Major connexin protein that forms intercellular gap-junction channels and unopposed hemichannels. CX43 regulates direct cell-to-cell communication, ion and metabolite transfer, calcium signaling, proliferation, differentiation, migration, inflammatory signaling, and interactions between tumor cells and the surrounding stroma.

Cancer: ↕ Context-dependent. CX43 frequently acts as a tumor suppressor during early tumorigenesis by maintaining gap-junction intercellular communication and limiting proliferation. However, CX43 can become pro-tumorigenic during later disease stages by promoting migration, invasion, tumor-stromal communication, survival, and metastatic colonization. Direction therefore depends strongly on cancer type, disease stage, cellular localization, and whether gap-junction, hemichannel, or non-channel functions predominate.

Alzheimer's Disease: ↑ CX43 expression and hemichannel activity are increased in reactive astrocytes associated with amyloid plaques. Excessive CX43 hemichannel opening can promote ATP and glutamate release, abnormal Ca2+ signaling, neuroinflammation, and neuronal injury. CX43 hemichannel inhibition has shown neuroprotective effects in experimental amyloidosis models.
Scientific Papers found: Click to Expand⟱
8728- M-Blu,    Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
- Review, AD, NA
*Dose↝, *antiOx↑, *mitResp↑, *neuroP↑, *memory↑, *CellMemb↑, *BBB↑, *other↝, *compV↑, *OCR↑, *ROS↓, *Sepsis↓, *NO↓, *RNS↓, *memory↑, *tau↓, *CX43/GJA1↑, *THBD↑, *CARTPT↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   RNS↓, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compV↑, 1,   mitResp↑, 1,   OCR↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   THBD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

CARTPT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 2,   neuroP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 18

Scientific Paper Hit Count for: CX43/GJA1, Connexin 43 / Gap Junction Protein Alpha 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1621  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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