Learn Cancer Research Results

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Scientific Papers found: Click to Expand⟱
7516- CA,    Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *memory↑, *Learn↑, *cognitive↑, *ROS↓, *lipid-P↓, *NRF2↑, *HO-1↑, *Aβ↓, *BACE/β-secretase↓,
7520- CAPE,    Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway
- in-vivo, AD, NA
*ROS↓, *NRF2↑, *HO-1↑, *Apoptosis↓, *Inflam↓, *Learn↑, *memory↑, *cognitive↑, *neuroP↑, *p‑GSK‐3β↓, GFAP↓,
7522- DFE,    Diet rich in date palm fruits improves memory, learning and reduces beta amyloid in transgenic mouse model of Alzheimer's disease
- in-vivo, AD, NA
*Aβ↓, *neuroP↑, *motorD↑, *memory↑, *Learn↑,
7530- HT,    The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease
- in-vivo, AD, NA
*Learn↑, *Copper↓,
7566- HYP,    Hyperoside improves learning and memory deficits by amyloid β1-42 in mice through regulating synaptic calcium-permeable AMPA receptors
- in-vivo, AD, NA
*Learn↑, *memory↑, *Aβ↓,
7544- HYP,    Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*Learn↑, *memory↑, *Aβ↓, *p‑tau↓, *Inflam↓, *ROS↓, *BACE/β-secretase↓, *GSK‐3β↓,
7759- ISL,  Rad,    Isoliquiritigenin, a Bioactive Blood Component Derived from Licorice, Activates Nrf2 Enzymes to Confer Protection Against Radiation-Induced Nerve Injury
- vitro+vivo, Nor, PC12
*radioP↑, *LDH↓, *ROS↓, *SOD1↑, *GSH↑, *TAC↑, *NRF2↓, *cognitive↑, *Learn↑, *memory↑,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7799- ISQ,    Acer okamotoanum and isoquercitrin improve cognitive function via attenuation of oxidative stress in high fat diet- and amyloid beta-induced mice
- in-vivo, AD, NA
*cognitive↑, *Learn↑, *memory↓, *ROS↓, *lipid-P↓, *NO↓,
7821- ISQ,    Quercitrin improved cognitive impairment through inhibiting inflammation induced by microglia in Alzheimer's disease mice
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *Aβ↓, *neuroP↑, *memory↑, *Learn↑,
8084- KAE,    Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling
- in-vivo, AD, NA
*Learn↑, *memory↑, *GAD1/GAD67↑, *RELN↑, *p‑NMDAR↑, *neuroP↑,
8069- KAE,    Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Learn↑, *memory↑, *SOD↑, *GSH↑, *TNF-α↓, *MDA↓,
7827- KAE,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *Learn↑, *memory↑, *antiOx↑, *Inflam↓, *Aβ↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑, *ERβ/ESR2↑, *ERK↑, *ROS↓, *AChE↓, *Dose↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
8329- LIN,    Microglial-targeting induced by intranasal linalool during neurological protection postischemia
- in-vivo, Stroke, NA - in-vivo, AD, NA
*Stroke↓, *BioAv↑, *neuroP↑, *motorD↑, *Learn↑, *COX2/PTGS2↓, *IL1β↓, *NRF2↑, *Dose↝, *cognitive↑,
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,
8351- Lut,  Zeax,    Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial
- Trial, AD, NA
*Dose↝, *cognitive↑, *Learn↑, *neuroP↑,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
8522- MAG,    Effects of magnolol on impairment of learning and memory abilities induced by scopolamine in mice
- in-vivo, AD, NA
*Learn↑, *memory↑, AChE↓, NOS2↑, SOD↑, MDA↓,
8539- Matr,    Matrine ameliorates cognitive deficits via inhibition of microglia mediated neuroinflammation in an Alzheimer's disease mouse model
- in-vivo, AD, NA
*Inflam↓, *Dose↝, *memory↑, *Learn↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓,
8560- Matr,    Matrine: A Promising Natural Product With Various Pharmacological Activities
- Review, AD, NA - Review, Stroke, NA - Review, Var, NA
*antiAll↑, *Stroke↓, *AntiArt↑, TumCCA↑, VEGF↓, Apoptosis↑, P53↑, P21↑, PCNA↓, EIF4E↓, TumCP↓, TumCMig↓, IAP1↓, ROS↑, EMT↓, PAX2↓, ER Stress↑, HK2↓, Apoptosis↑, STAT3↓, mtDam↑, HMGB1↓, ChemoSen↑, p‑GSK‐3β↓, P-gp/ABCB1↓, MRP1/ABCC1↓, Vim↓, cycD1/CCND1↓, CDK4↓, GSH↓, SOD↓, mt-Cyt‑c↓, BAX↑, MMP9↓, MMP2↓, E-cadherin↓, N-cadherin↓, FOXO1↓, FOXO3↓, FOXO4↓, PI3K↓, ATF4↑, CHOP/DDIT3↑, *Aβ↓, *RAGE↓, *memory↑, *Learn↑, *cognitive↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *antiAll↑, *AHR↓, *SOCS-3↓, *ICAM-1↓, *ROS↓, cachexia↓, *BACE/β-secretase↓, *NF-kB↓, *TNF-α↓, *IL1β↓,
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,
8455- Mg,    Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis
- in-vivo, AD, NA
*Learn↑, *memory↑, *cognitive↑, *ROS↓, *Inflam↓, *GutMicro↑, *IBI↑, *MDA↓, *SOD↑, *Catalase↑, *TNF-α↓, *IL1β↓, *IL10↑,
8689- MLT,    Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
- Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *NeuroI↓, *Apoptosis↓, *mtDam↓, *GSK‐3β↓, *p‑tau↓, *GFAP↓, *TNF-α↓, *IL6↓, *BACE/β-secretase↓, *PSEN1/PS1↓, *NF-kB↓, *TFAM↑, *Nrf1↑, *NRF2↑, *PGC-1α↑, *MMP↑, *GSH↑, *lipid-P↓, *ChAT↑, *TBARS↓, *SOD↑, *Ca+2↓, *AChE↓, *H2O2↓, *MDA↓, *TAC↑, *SOD↑, *Catalase↑, *BDNF↑, *Bcl-2↑, *Ach↑, *memory↑, *Learn↑, *GSK‐3β↓, *SNAP25↑, *PSD95↑, *p‑CREB↑, *GFAP↓, *RELN↑, *SIRT1↑, *TFAM↑, *APP↓, *ER Stress↓, *GRP78/BiP↓, *Sleep↑, *cognitive↑, *Synergy↑, *NeuroI↓,
8657- MLT,    Melatonin in Alzheimer's Disease: Literature Review and Therapeutic Trials
- Review, AD, NA
*toxicity↓, *Sleep↑, *antiOx↑, *AntiMyl↑, *p‑tau↓, *Aβ↓, *TC↓, *neuroP↑, *ROS↓, *BBB↑, *Learn↑, *memory↑, *Synergy↑, *Dose↝,
8451- Oreg,    A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
- in-vivo, AD, NA
*Learn↑, *memory↑, *AChE↓, *ROS↓, *COX2/PTGS2↓, *iNOS↓,
7834- VA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *memory↑, *Learn↑, *Aβ↓, *BACE/β-secretase↓, *NeuroI↓, *RAGE↓, *antiOx↑, *NRF2↑, *HO-1↑, *GSK‐3β↓, *ROS↓, *AChE↓, *Dose↝,
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,

Showing Research Papers: 1 to 29 of 29

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 29

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx4↓, 1,   GSH↓, 2,   Iron↑, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   ROS↑, 2,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑GSK‐3β↓, 1,   HK2↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   mt-Cyt‑c↓, 1,   Ferroptosis↑, 1,   GranB/GZMB↝, 1,   IAP1↓, 1,   Perforin↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JAK2↓, 1,   PI3K↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↑, 1,   FOXO1↓, 1,   FOXO3↓, 1,   FOXO4↓, 1,   PAX2↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EIF4E↓, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCMig↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   PD-L1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↑, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cachexia↓, 1,   hepatoP↑, 1,  
Total Targets: 56

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   ARE↑, 1,   Catalase↓, 1,   Catalase↑, 4,   Copper↓, 1,   GPx↑, 2,   GSH↑, 5,   GSTs↓, 1,   H2O2↓, 1,   HO-1↑, 5,   lipid-P↓, 6,   MDA↓, 6,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 11,   ONOO↓, 1,   ROS↓, 18,   SOD↓, 1,   SOD↑, 8,   SOD1↑, 1,   TAC↑, 3,   TBARS↓, 1,   TOS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 2,   PGC-1α↑, 1,   TFAM↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,   GSK‐3β↓, 4,   p‑GSK‐3β↓, 1,   p‑GSK‐3β↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 4,   BAX↓, 2,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp12↓, 1,   Casp3↓, 2,   Casp9↓, 1,   iNOS↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   CREB↑, 1,   p‑CREB↑, 1,   ERK↑, 1,   JNK↓, 1,   p‑JNK↓, 1,   PI3K↑, 1,   PROKR1↑, 1,   PROKR2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 3,   GRP78/BiP↓, 3,   IRE1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   MMP9↓, 1,   PROK2↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 4,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   BBB∅, 2,   IBI↑, 1,   MMP↑, 4,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IL10↑, 1,   IL1β↓, 7,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 12,   MIP‑1α/CCL3↓, 1,   NeuroI↓, 5,   NF-kB↓, 5,   NLRP3↓, 1,   RAGE↓, 2,   SOCS-3↓, 1,   TNF-α↓, 9,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

Ach↑, 1,   AChE↓, 7,   ADAM10↑, 2,   BDNF↑, 7,   ChAT↑, 1,   GAD1/GAD67↑, 1,   GDNF↑, 1,   MAOA↓, 1,   NGF↑, 1,   p‑NMDAR↑, 1,   PSD95↑, 5,   RELN↑, 2,   SNAP25↑, 3,   SYP↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

APOE4↓, 1,   APP↓, 2,   cl‑APP↑, 1,   Aβ↓, 11,   Aβ42↓, 2,   BACE/β-secretase↓, 8,   PSEN1/PS1↓, 1,   PSEN1/PS1↑, 1,   p‑tau↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AHR↓, 1,   ERβ/ESR2↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 2,   Dose↑, 1,   Dose↝, 7,   eff↑, 1,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 5,   LDH↓, 1,   NOS2↓, 1,   RAGE↓, 2,   TC↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   AntiMyl↑, 2,   AntiTum↑, 1,   cardioP↑, 1,   cognitive↑, 17,   Learn↑, 29,   memory↓, 1,   memory↑, 24,   motorD↑, 3,   neuroP↑, 19,   radioP↑, 1,   Sleep↑, 2,   Stroke↓, 3,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   GutMicro↑, 1,  
Total Targets: 140

Scientific Paper Hit Count for: Learn, Learning
3 Kaempferol
3 Matrine
2 Hyperoside
2 Isoliquiritigenin
2 isoquercitrin
2 Mung Bean Sprouts
2 Luteolin
2 Melatonin
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Date Fruit Extract
1 HydroxyTyrosol
1 Radiotherapy/Radiation
1 Lactoferrin/Talactoferrin
1 Linalool
1 Lutein
1 Zeaxanthin
1 Lycopene
1 Magnolol
1 Magnesium
1 Oregano
1 Vanillic Acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1656  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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