SYP Cancer Research Results

SYP, synaptophysin: Click to Expand ⟱
Source:
Type:

SYP - Synaptophysin

Abbreviation: SYP, Synaptophysin

Type: Presynaptic vesicle membrane protein / synaptic density biomarker / neuroendocrine marker

Function: Synaptophysin is an abundant integral membrane glycoprotein of presynaptic vesicles. It participates in synaptic vesicle organization, trafficking, exocytosis, and recycling and is widely used as a marker of presynaptic terminals and synaptic density. In pathology, SYP is also a standard marker of neuroendocrine differentiation.

Cancer: ↕ Context-dependent / lineage marker. Synaptophysin is frequently increased in neuroendocrine malignancies and is widely used diagnostically to identify neuroendocrine differentiation, including small-cell lung cancer, neuroendocrine prostate cancer, carcinoid tumors, and other neuroendocrine neoplasms. Increased SYP generally reflects neuroendocrine phenotype rather than a universal tumor-promoting mechanism.

Alzheimer's Disease: ↓ Reduced synaptophysin is a well-established marker of presynaptic and synaptic loss in Alzheimer's disease. Lower SYP levels are associated with synaptic degeneration and correlate with cognitive impairment and disease severity.
Scientific Papers found: Click to Expand⟱
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
8507- MAG,    Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*Dose?, *cognitive↑, *Aβ↓, *NeuroI↓, *neuroP↑, *tau↓, *GFAP↓, *AIF1/Iba-1↓, *GSK‐3β↑, *SYP↑, *BDNF↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

Bax:Bcl2↓, 1,   Bcl-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   MIP‑1α/CCL3↓, 1,   NeuroI↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   PSD95↑, 1,   SYP↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 2,   Learn↑, 1,   neuroP↑, 1,  
Total Targets: 27

Scientific Paper Hit Count for: SYP, synaptophysin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1698  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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