IL13 Cancer Research Results

IL13, Interleukin-13: Click to Expand ⟱
Source:
Type:

IL-13 - Interleukin-13

Type: Type-2 cytokine / immune signaling protein

Function: IL-13 is a type-2 immune cytokine produced by cells including group 2 innate lymphoid cells (ILC2), Th2 lymphocytes, mast cells, and eosinophils. IL-13 signals primarily through a receptor complex containing IL-13Rα1 and IL-4Rα, activating JAK/STAT6 and related pathways. It regulates alternative macrophage activation, mucus production, fibrosis, tissue remodeling, allergic inflammation, and type-2 immune responses.

Cancer: ↑ Frequently increased or functionally activated in tumor-associated type-2 immune responses. IL-13 can promote immunosuppressive macrophage polarization, stromal remodeling, fibrosis, tumor-cell survival, migration, invasion, and metastasis through IL-13 receptor and STAT6 signaling. Its effects remain tumor- and immune-context dependent.

Alzheimer's Disease: ↕ Context-dependent. IL-13 can modulate microglial and macrophage activation toward alternative immune phenotypes and may reduce selected pro-inflammatory responses, but its effects on amyloid pathology, neuroinflammation, and neuronal function vary by model and disease stage.
Scientific Papers found: Click to Expand⟱
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Casp8↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↑, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   IBI↑, 1,   OCLN↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↑, 1,   IL13↑, 1,   NF-kB↑, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,  
Total Targets: 16

Scientific Paper Hit Count for: IL13, Interleukin-13
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1723  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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