CYP51/14LDM Cancer Research Results

CYP51/14LDM, Lanosterol 14α-Demethylase: Click to Expand ⟱
Source:
Type:

CYP51A1 - Lanosterol 14α-Demethylase

Abbreviation: CYP51A1, CYP51, 14LDM, Lanosterol 14α-Demethylase

Type: Cytochrome P450 enzyme / cholesterol biosynthesis enzyme

Function: CYP51A1 catalyzes oxidative removal of the 14α-methyl group from lanosterol and related sterol intermediates during cholesterol biosynthesis. It is an evolutionarily conserved sterol-demethylating enzyme and is essential for normal sterol and membrane-lipid homeostasis.

Cancer: ↕ Context-dependent. CYP51A1 can support cholesterol and sterol synthesis in metabolically active tumor cells, but its expression and importance vary by cancer type, so no universal cancer-associated direction is appropriate.
Scientific Papers found: Click to Expand⟱
8548- Matr,    The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway
*insect↑, *hepatoP↓, *ALAT↑, *AST↑, *CYP51/14LDM↑, *DHCR7↑, *toxicity↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CYP51/14LDM↑, 1,   insect↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

DHCR7↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↓, 1,   toxicity↝, 1,  
Total Targets: 8

Scientific Paper Hit Count for: CYP51/14LDM, Lanosterol 14α-Demethylase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1748  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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