CHRM1 Cancer Research Results

CHRM1, Cholinergic Receptor Muscarinic 1: Click to Expand ⟱
Source:
Type:

CHRM1 - Cholinergic Receptor Muscarinic 1

Abbreviation: CHRM1, M1, M1 mAChR

Alternative Names: Muscarinic Acetylcholine Receptor M1

Type: G protein-coupled receptor / muscarinic acetylcholine receptor / cholinergic signaling receptor

Function: CHRM1 is a Gq/11-coupled muscarinic acetylcholine receptor expressed prominently in the central nervous system and in selected peripheral tissues. Activation stimulates phospholipase C, intracellular Ca2+ signaling, PKC, MAPK/ERK, and other downstream pathways involved in neuronal excitability, synaptic plasticity, cognition, secretion, proliferation, and cell survival.

Alzheimer's Disease: ↓ / impaired M1 muscarinic signaling is associated with cholinergic dysfunction in Alzheimer's disease. CHRM1 activation can improve cholinergic neurotransmission and cognition and can promote non-amyloidogenic APP processing while reducing Aβ formation and tau phosphorylation in experimental models.

Favorable Direction in Alzheimer's Disease: ↑ CHRM1 activation or restoration of normal M1 signaling is generally favorable.

Cancer: ↕ Context-dependent. CHRM1 signaling can either suppress or promote tumor progression depending on tissue type. In pancreatic cancer models, CHRM1 activation suppresses tumor growth and cancer stemness, whereas in other cancers, including selected skin cancer models, CHRM1 signaling may support proliferation and survival.

Favorable Direction in Cancer: Context-dependent and should be assigned according to tumor type and experimentally observed signaling response.
Scientific Papers found: Click to Expand⟱
8493- MAG,    Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway
- in-vitro, AD, SH-SY5Y
*neuroP↑, *Aβ↓, *p‑tau↓, *Apoptosis↓, *CHRM1↑, *cAMP↑, *PKA↑, *CREB↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CHRM1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cAMP↑, 1,   CREB↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

PKA↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: CHRM1, Cholinergic Receptor Muscarinic 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1842  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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