DHCR7 Cancer Research Results

DHCR7, 7-dehydrocholesterol reductase: Click to Expand ⟱
Source:
Type:

DHCR7 (7-Dehydrocholesterol Reductase) — Endoplasmic-reticulum membrane oxidoreductase that catalyzes the reduction of 7-dehydrocholesterol (7-DHC) to cholesterol, a terminal step in cholesterol biosynthesis. DHCR7 regulates cellular sterol composition, cholesterol availability, membrane biology, and downstream lipid-dependent signaling.

Typical modulation in cancer: Frequently ↑ in cancer and generally tumor-promoting in several contexts. Elevated DHCR7 has been associated with increased proliferation, invasion, migration, metastasis, altered tumor immunity, and poorer prognosis. In colorectal cancer, DHCR7 ↑ promotes cholesterol accumulation and activates PI3K/AKT/mTOR signaling, whereas DHCR7 inhibition suppresses tumorigenic phenotypes.

Typical modulation in Alzheimer’s disease: Context-dependent. DHCR7 influences cholesterol and 7-DHC metabolism, both of which can affect neuronal membrane composition, oxidative stress, and sterol-dependent signaling. However, a consistent AD-specific disease direction is not established.

Additional relevance: DHCR7 can also influence ferroptosis through sterol metabolism and susceptibility to lipid peroxidation.
Scientific Papers found: Click to Expand⟱
8548- Matr,    The DHCR7 is the key target of lipotoxic liver injury caused by matrine through abnormal activation of the cholesterol synthesis pathway
*insect↑, *hepatoP↓, *ALAT↑, *AST↑, *CYP51/14LDM↑, *DHCR7↑, *toxicity↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CYP51/14LDM↑, 1,   insect↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

DHCR7↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↓, 1,   toxicity↝, 1,  
Total Targets: 8

Scientific Paper Hit Count for: DHCR7, 7-dehydrocholesterol reductase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1857  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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