PROK2 Cancer Research Results

PROK2, Prokineticin 2; PK2/Bv8: Click to Expand ⟱
Source:
Type:

PROK2 (Prokineticin 2; PK2/Bv8) — Secreted prokineticin-family signaling protein and ligand for the G-protein-coupled receptors PROKR1 and PROKR2. PROK2 regulates angiogenesis, endothelial-cell proliferation, chemotaxis, circadian signaling, neurogenesis, inflammation, and smooth-muscle activity.

Typical modulation in cancer: ↑ PROK2 is generally tumor-promoting in cancers where the PROK2 pathway is active, particularly through increased angiogenesis, recruitment of pro-angiogenic myeloid cells, migration, and tumor-supporting inflammatory signaling. PROK2 inhibition is therefore generally considered anticancer in these contexts.

Typical modulation in Alzheimer’s disease: Context-dependent. PROK2 participates in circadian and neuronal signaling and can be induced by cellular stress, but there is not a sufficiently established universal AD direction.
Scientific Papers found: Click to Expand⟱
8556- Matr,    Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway
- in-vivo, AD, NA - in-vivo, Diabetic, NA
*AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *glucose↓, *Learn↑, *memory↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *ATF6↓, *Casp12↓, *PROK2↑, *PROKR1↑, *PROKR2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Cell Death(tgid=5) ⓘ

Casp12↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

PROKR1↑, 1,   PROKR2↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,  

Migration(tgid=13) ⓘ

PROK2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   Learn↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 15

Scientific Paper Hit Count for: PROK2, Prokineticin 2; PK2/Bv8
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:%  Target#:1864  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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